Potential role of liver enzyme levels as predictive markers of glucose metabolism disorders in a Tunisian population

Abstract

The relationship between liver enzymes and T2D risk is inconclusive. We aimed to evaluate the association between liver markers and risk of carbohydrate metabolism disorders, as well as their discriminatory power, for T2D prediction. This cross-sectional study enrolled 216 participants classified as normoglycemic, prediabetic, newly diagnosed diabetics, and diagnosed diabetics. All participants underwent anthropometric and biochemical measurements. The relationship between hepatic enzymes and glucose metabolism markers was evaluated by analyses of covariance. The associations between liver enzymes and incident carbohydrate metabolism disorders were analyzed through logistic regression and their discriminatory capacity to predict T2D by ROC analysis. High AP, ALT, γGT, and AST levels were independently related to decreased insulin sensitivity. Interestingly, a higher AP level was significantly associated with an increased risk of prediabetes (p = 0.017), newly diagnosed diabetes (p = 0.004), and T2D (p = 0.007). An elevated γGT level was an independent risk factor for T2D (p = 0.032) and undiagnosed T2D (p = 0.010) in prediabetic and normoglycemic subjects, respectively. In ROC analysis, AP was a powerful predictor of incident diabetes and significantly improved T2D prediction. Liver enzymes within the normal range, specifically AP levels, are associated with increased risk of carbohydrate metabolism disorders and significantly improved T2D prediction.

Muscle Function Differences between Patients with Bulbar and Spinal Onset Amyotrophic Lateral Sclerosis. Does It Depend on Peripheral Glucose?

“…Thus, determining the values of Alkaline Phosphatase (AP) could be highly effective, since high levels may be associated with high bone destruction, on one hand [15], or biliary obstruction, on the other hand, if the AP and the gamma-glutamyl transferase (GGT) levels are also elevated [16]. However, if GGT is not elevated, or if there is evidence that the patient does not suffer from bone resorption, increased values of AP have been related to alterations in glucose metabolism, more precisely with insulin resistance, leading to alterations of the glucose metabolism by limiting glucose entry to the cell [14,17,18].…”

Effect of 8 Weeks of Sodium Alginate Supplementation with HIIT and MICT on Liver Enzymes and Lipid Profile in Men with Metabolic Syndrome

“…Liver enzymes and lipid profile are closely linked to MetS (3). The role of liver enzymes, mainly aspartate aminotransferase (AST), alanine aminotransferase (ALT), and to a lesser extent, alkaline phosphatase (ALP), has recently been recognized as potential new markers in the development of type 2 diabetes and MetS (4). The liver, as a central organ for glucose and lipid metabolism, is severely affected by MetS (5).…”