Potential role of irisin in digestive system diseases

Zhang, Yueming; Zhao, Linxian; Gao, Huan; Zhai, Jinghui; Song, Yanqing

doi:10.1016/j.biopha.2023.115347

Cited by 2 publications

(1 citation statement)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, irisin has been shown to bind to the αVβ5 receptor on gut epithelial cells both in vitro and in vivo, stressing its potential role in the digestive system [23]. Presumably, this peptide could exert beneficial effects by interacting with this integrin on various tissues, including the tissues of the GI tract [23][24][25].…”

Section: Detection Of Irisinmentioning

confidence: 99%

The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract

Pinkas,

Brzozowski

2024

Antioxidants

View full text Add to dashboard Cite

Recently discovered irisin, a member of the myokines family, is a potential mediator of exercise-induced energy metabolism and a factor promoting browning of the white adipose tissue. Recent evidence indicates that this myokine, released from contracting muscles, can mediate the beneficial effects of exercise on health. Irisin may be a potential therapeutic agent against obesity and has been shown to play an important role in the protection of various cells, tissues, and organs due to its anti-inflammatory, antioxidative, and anti-cancer properties. Our aim was to review the recent experimental and clinical studies on irisin and its expression, release into the bloodstream, tissue targets, and potential contribution to the protective effects of exercise in the gastrointestinal tract. Particular emphasis was placed on inflammatory bowel disease, intestinal ischemia/reperfusion injury, periodontitis, and other digestive tract disorders, including carcinogenesis. Overall, irisin holds significant potential as a novel target molecule, offering a safe and therapeutic approach to treating various gastrointestinal diseases.

show abstract