1993
DOI: 10.1002/hep.1840170623
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Potential role of hepatic macrophages in neutrophil-mediated liver injury in rats with sepsis

Abstract: We investigated the pathogenesis of septic liver injury in rats caused by cecal ligation and puncture. In this model, numerous neutrophils accumulated in the liver in parallel with the development of liver dysfunction. The supernatants of hepatic macrophages isolated from these septic rats 24 hr after cecal ligation and puncture had enhanced chemotactic activities for human neutrophils. These results suggest that in sepsis, hepatic macrophages attract neutrophils to the liver. Human neutrophils preincubated in… Show more

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Cited by 57 publications
(11 citation statements)
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“…Potential causes include secondary dysfunction related to crosstalk with other failing organs, 32 ongoing damage to hepatocytes by inflammatory mediators, 35 and microvascular thrombosis of the liver sinusoids secondary to ongoing inflammation. 36 Patients with severe sepsis and septic shock had fewer ventilator-free days and fewer ICU-free days than those with sepsis (p Ͼ 0.001). In addition, patients with severe sepsis and septic shock were less likely to be discharged directly home.…”
Section: Discussionmentioning
confidence: 95%
“…Potential causes include secondary dysfunction related to crosstalk with other failing organs, 32 ongoing damage to hepatocytes by inflammatory mediators, 35 and microvascular thrombosis of the liver sinusoids secondary to ongoing inflammation. 36 Patients with severe sepsis and septic shock had fewer ventilator-free days and fewer ICU-free days than those with sepsis (p Ͼ 0.001). In addition, patients with severe sepsis and septic shock were less likely to be discharged directly home.…”
Section: Discussionmentioning
confidence: 95%
“…During the process of septic response, activated KCs release leukotriene B4 and TNF-α, which in turn attract blood neutrophils into the liver and activate them. [16] Apoptotic hepatocytes have also been shown to function as chemotactic signals, triggering neutrophil transmigration. [17] Upregulation of endothelial integrins and intercellular adhesion molecule (ICAM)-1 also promotes neutrophil migration in LPS-induced liver injury.…”
Section: Pathophysiological Changes In Sepsis-associated Liver Dysfunmentioning
confidence: 99%
“…9 Kupffer cell activation appears to play a kine response, resulting in endotoxin tolerance. To study the effects of phosphocretors.…”
mentioning
confidence: 99%
“…9 Kupffer cell activation appears to play a kine response, resulting in endotoxin tolerance. 9 Kupffer cell activation appears to play a kine response, resulting in endotoxin tolerance.…”
mentioning
confidence: 99%