Potential role of gut microbiota-LCA-INSR axis in high fat-diet-induced non-alcoholic fatty liver dysfunction: From perspective of radiation variation

Pan, Huiji; Zhou, Meiling; Zhao, Jiang; Luo, Juhua; Jin, Jing; Shen, Liangfang; Zhou, Pingkun; Huang, Ruixue

doi:10.1016/j.crfs.2022.09.022

Cited by 3 publications

(1 citation statement)

References 64 publications

(64 reference statements)

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“…Furthermore, the IL-17 and VEGF signaling pathways may contribute to a decrease in HF ( Kumar et al, 2016 ; Fabre et al, 2018 ; Martínez-López et al, 2019 ; Qiao et al, 2020 ; Ghanim et al, 2021 ; He et al, 2022 ). Huiji Pan et al discovered that gut microbiota influence H-L + HFD-induced liver fibrosis through alteration of the hepatic IRS1/Akt/mTOR signaling pathway ( Pan et al, 2022 ). According to Jiang’s study ( Jiang et al, 2020 ), Lactobacillus may enhance the intestinal milieu and alleviate the condition, and the level of VEGF is also dramatically lowered with the reduction of liver cancer.…”

Section: Discussionmentioning

confidence: 99%

Exploration of the potential mechanism of Baicalin for hepatic fibrosis based on network pharmacology, gut microbiota, and experimental validation

et al. 2023

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Baicalin (BA) is among the most effective and abundant flavonoids extracted from Scutellaria baicalensis that may be utilized to treat diseases associated with hepatic fibrosis (HF). Through network pharmacology, gut microbiota, and experimental validation, this research intends to elucidate the multi-target mechanism of BA on HF. BA targets were screened using databases and literature. As a result, In the anti-HF mechanism, the BA and 191 HF-associated targets interact, with 9 specific targets indicating that the BA’s anti-HF mechanism is closely linked to gut microbiota. Consequently, rat intestinal content samples were obtained and examined using 16S rRNA sequencing. In the BA-treated group, the gut microbiota was positively regulated at the phylum,and genus levels, with Lactobacillus performing significantly. The study concluded that BA has a multi-targeted anti-HF effect and has changed the gut microbial ecosystem.

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Section: Discussionmentioning

confidence: 99%

Exploration of the potential mechanism of Baicalin for hepatic fibrosis based on network pharmacology, gut microbiota, and experimental validation

et al. 2023

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Gut microbial dysbiosis is associated with metabolism and immune factors in liver fibrosis mice

Zhao,

Jin,

Shi

et al. 2024

International Journal of Biological Macromolecules

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Encouraging Tactics with Genetically Modified Probiotics to Improve Immunity for the Prevention of Immune-Related Diseases including Cardio-Metabolic Disorders

et al. 2022

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The PI3K/AKT/mTOR signaling pathway may play crucial roles in the pathogenesis of obesity and diabetes mellitus, as well as metabolic syndromes, which could also be risk factors for cardio-metabolic disorders. Consistently, it has been shown that beneficial effects may be convoyed by the modulation of the PI3K/AKT/mTOR pathway against the development of these diseases. Importantly, the PI3K/AKT/mTOR signaling pathway can be modulated by probiotics. Probiotics have a variety of beneficial properties, with the potential of treating specific diseases such as immune-related diseases, which are valuable to human health. In addition, an increasing body of work in the literature emphasized the contribution of genetically modified probiotics. There now seems to be a turning point in the research of probiotics. A better understanding of the interactions between microbiota, lifestyle, and host factors such as genetics and/or epigenetics might lead to a novel therapeutic approach with probiotics for these diseases. This study might provide a theoretical reference for the development of genetically modified probiotics in health products and/or in functional foods for the treatment of cardio-metabolic disorders.

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Potential role of gut microbiota-LCA-INSR axis in high fat-diet-induced non-alcoholic fatty liver dysfunction: From perspective of radiation variation

Cited by 3 publications

References 64 publications

Exploration of the potential mechanism of Baicalin for hepatic fibrosis based on network pharmacology, gut microbiota, and experimental validation

Exploration of the potential mechanism of Baicalin for hepatic fibrosis based on network pharmacology, gut microbiota, and experimental validation

Gut microbial dysbiosis is associated with metabolism and immune factors in liver fibrosis mice

Encouraging Tactics with Genetically Modified Probiotics to Improve Immunity for the Prevention of Immune-Related Diseases including Cardio-Metabolic Disorders

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