Potential role of gut microbiota and its metabolites in radiation-induced intestinal damage

Xin, Jiayun; Wang, Jie; Ding, Qianqian; Chen, Wei; Xu, Xiaoqing; Wei, Xin‐Tong; Lv, Yan-Hui; Wei, Yanping; Ye, Feng; Zu, Xianpeng

doi:10.1016/j.ecoenv.2022.114341

Cited by 11 publications

(6 citation statements)

References 120 publications

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“…Apart from barrier damage and in ammation response, intestinal ora imbalance has been regarded as a main reason for radiation induced intestinal injury. [42,43] Thus, we examined the composition and abundance of gut microbiota by 16S ribosomal DNA (16S rDNA) identi cation amplicon sequencing after different treatments. Operational taxonomic units (OTUs) were clustered at 97% similarity (Figure S10).…”

Section: In Vivo Biodistribution and Radioprotective Effectmentioning

confidence: 99%

Oral Administration of Probiotic Spore Ghosts for Efficient Attenuation of Radiation-Induced Intestinal Injury

Zheng,

Niu,

Kong

et al. 2024

Preprint

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Radiation-induced intestinal injury is the most common side effect during radiotherapy of abdominal or pelvic solid tumors significantly impacting patients’ quality of life and even resulting in poor prognosis. Until now, oral application of conventional formulations for intestinal radioprotection remains challenging with no preferred method available to mitigate radiation toxicity in small intestine. Our previous study revealed that nanomaterials derived from spore coat of probiotics exhibit superior anti-inflammatory effect and even prevent the progression of cancer. The aim of this work is to determine the radioprotective effect of spore coat (denoted as spore ghosts, SGs) from three clinically approved probiotics (B.coagulans, B.subtilis and B.licheniformis). All the three SGs exhibit outstanding reactive oxygen species (ROS) scavenging ability and excellent anti-inflammatory effect. Moreover, these SGs can reverse the balance of intestinal flora by inhibiting harmful bacteria and increasing the abundance of Lactobacillus. Consequently, administration of SGs significantly reduce radiation-induce intestinal injury by alleviating diarrhea, preventing X-ray induced apoptosis of small intestinal crypt epithelial cells and promoting restoration of barrier integrity in a prophylactic study. Notably, SGs markedly improve weight gain and survival of mice received total abdominal X-ray radiation. This work may provide promising radioprotectants for efficiently attenuating radiation-induced gastrointestinal syndrome and promote the development of new intestinal predilection.

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Section: In Vivo Biodistribution and Radioprotective Effectmentioning

confidence: 99%

Oral Administration of Probiotic Spore Ghosts for Efficient Attenuation of Radiation-Induced Intestinal Injury

Zheng,

Niu,

Kong

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Apart from barrier damage and inflammation response, intestinal flora imbalance has been regarded as a main reason for radiation induced intestinal injury [42,43]. Thus, we examined the composition and abundance of gut microbiota by 16 S ribosomal DNA (16 S rDNA) identification amplicon sequencing after different treatments.…”

Section: In Vivo Biodistribution and Radioprotective Effectmentioning

confidence: 99%

Oral administration of probiotic spore ghosts for efficient attenuation of radiation-induced intestinal injury

Zheng,

Niu,

Kong

et al. 2024

J Nanobiotechnol

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Radiation-induced intestinal injury is the most common side effect during radiotherapy of abdominal or pelvic solid tumors, significantly impacting patients’ quality of life and even resulting in poor prognosis. Until now, oral application of conventional formulations for intestinal radioprotection remains challenging with no preferred method available to mitigate radiation toxicity in small intestine. Our previous study revealed that nanomaterials derived from spore coat of probiotics exhibit superior anti-inflammatory effect and even prevent the progression of cancer. The aim of this work is to determine the radioprotective effect of spore coat (denoted as spore ghosts, SGs) from three clinically approved probiotics (B.coagulans, B.subtilis and B.licheniformis). All the three SGs exhibit outstanding reactive oxygen species (ROS) scavenging ability and excellent anti-inflammatory effect. Moreover, these SGs can reverse the balance of intestinal flora by inhibiting harmful bacteria and increasing the abundance of Lactobacillus. Consequently, administration of SGs significantly reduce radiation-induced intestinal injury by alleviating diarrhea, preventing X-ray induced apoptosis of small intestinal epithelial cells and promoting restoration of barrier integrity in a prophylactic study. Notably, SGs markedly improve weight gain and survival of mice received total abdominal X-ray radiation. This work may provide promising radioprotectants for efficiently attenuating radiation-induced gastrointestinal syndrome and promote the development of new intestinal predilection.

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“…In addition, its potential to also protect malignant tissues from radiotherapy still needs clarification [95]. To avoid these side effects and reduce injury to healthy intestinal tissues, researchers have investigated the use of bacterial food supplements instead, as safer radioprotectors including probiotics and prebiotics [96,97] They have been the primary focus of previous in vitro and in vivo research on radioprotection mechanisms, with antimicrobial, barrier-enhancing, and immunomodulatory capacities being the most extensively studied functions [57,71,96]. Intestinal cells treated with specific probiotics or prebiotics before and/or after radiation, have already suggested the potential of their action [97][98][99], but remain to be confirmed by dedicated clinical trials.…”

Section: Using Food Supplements To Mitigate Radiotoxicitymentioning

confidence: 99%

Human Intestinal Organoids and Microphysiological Systems for Modeling Radiotoxicity and Assessing Radioprotective Agents

Bouges,

Segers,

Leys

et al. 2023

Cancers

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Radiotherapy is a commonly employed treatment for colorectal cancer, yet its radiotoxicity-related impact on healthy tissues raises significant health concerns. This highlights the need to use radioprotective agents to mitigate these side effects. This review presents the current landscape of human translational radiobiology, outlining the limitations of existing models and proposing engineering solutions. We delve into radiotherapy principles, encompassing mechanisms of radiation-induced cell death and its influence on normal and cancerous colorectal cells. Furthermore, we explore the engineering aspects of microphysiological systems to represent radiotherapy-induced gastrointestinal toxicity and how to include the gut microbiota to study its role in treatment failure and success. This review ultimately highlights the main challenges and future pathways in translational research for pelvic radiotherapy-induced toxicity. This is achieved by developing a humanized in vitro model that mimics radiotherapy treatment conditions. An in vitro model should provide in-depth analyses of host-gut microbiota interactions and a deeper understanding of the underlying biological mechanisms of radioprotective food supplements. Additionally, it would be of great value if these models could produce high-throughput data using patient-derived samples to address the lack of human representability to complete clinical trials and improve patients’ quality of life.

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Potential role of gut microbiota and its metabolites in radiation-induced intestinal damage

Cited by 11 publications

References 120 publications

Oral Administration of Probiotic Spore Ghosts for Efficient Attenuation of Radiation-Induced Intestinal Injury

Oral Administration of Probiotic Spore Ghosts for Efficient Attenuation of Radiation-Induced Intestinal Injury

Oral administration of probiotic spore ghosts for efficient attenuation of radiation-induced intestinal injury

Human Intestinal Organoids and Microphysiological Systems for Modeling Radiotoxicity and Assessing Radioprotective Agents

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