Potential role of dietary ω-3 essential fatty acids on some oxidant/antioxidant parameters in rats’ corpus striatum

Sarsılmaz, Mustafa; Songür, Ahmet; Özyurt, Hüseyın; Kuş, İlter; Özen, Oğuz Aslan; Ozyurt, Birsen; Söğüt, Sadık; Akyol, Ömer

doi:10.1016/s0952-3278(03)00107-8

Cited by 104 publications

(79 citation statements)

References 37 publications

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“…Some studies have suggested that supplementation with PUFAs can result in antioxidant effects in a neurodegenerative disease model or cell culture system (Hashimoto et al, 2002;Sarsilmaz et al, 2003;Wang et al, 2003). On the contrary, other researchers have detected elevated lipid peroxidation under high oxidative stress conditions, including aging and neurodegenerative diseases (Youdim et al, 2000); with this modification, PUFA treatment exerted no protective effects against oxidative stress (Florent et al, 2006;FlorentBéchard et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Hempseed Meal Intake and Linoleic Acid on Drosophila Models of Neurodegenerative Diseases and Hypercholesterolemia

Lee

Park

Han

et al. 2011

Molecules and Cells

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Hempseed is rich in polyunsaturated fatty acids (PUFAs), which have potential as therapeutic compounds for the treatment of neurodegenerative and cardiovascular disease. However, the effect of hempseed meal (HSM) intake on the animal models of these diseases has yet to be elucidated. In this study, we assessed the effects of the intake of HSM and PUFAs on oxidative stress, cytotoxicity and neurological phenotypes, and cholesterol uptake, using Drosophila models. HSM intake was shown to reduce H 2 O 2 toxicity markedly, indicating that HSM exerts a profound antioxidant effect. Meanwhile, intake of HSM, as well as linoleic or linolenic acids (major PUFA components of HSM) was shown to ameliorate Aβ42-induced eye degeneration, thus suggesting that these compounds exert a protective effect against Aβ42 cytotoxicity. On the contrary, locomotion and longevity in the Parkinson's disease model and eye degeneration in the Huntington's disease model were unaffected by HSM feeding. Additionally, intake of HSM or linoleic acid was shown to reduce cholesterol uptake significantly. Moreover, linoleic acid intake has been shown to delay pupariation, and cholesterol feeding rescued the linoleic acid-induced larval growth delay, thereby indicating that linoleic acid acts antagonistically with cholesterol during larval growth. In conclusion, our results indicate that HSM and linoleic acid exert inhibitory effects on both Aβ42 cytotoxicity and cholesterol uptake, and are potential candidates for the treatment of Alzheimer's disease and cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

The Effects of Hempseed Meal Intake and Linoleic Acid on Drosophila Models of Neurodegenerative Diseases and Hypercholesterolemia

Lee

Park

Han

et al. 2011

Molecules and Cells

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“…However, docosahexaenoic acid (DHA), an -3 PUFA, has antiinflammatory properties and plays a role in the resolution of inflammation (Schwab et al, 2007;Serhan et al, 2008). In addition, DHA also has potent free radical scavenging and antioxidant properties (Endres and von Schacky, 1996;Sarsilmaz et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Fenretinide Promotes Functional Recovery and Tissue Protection after Spinal Cord Contusion Injury in Mice

López-Vales¹,

Redensek²,

Skinner³

et al. 2010

J. Neurosci.

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The inflammatory response is thought to contribute to secondary damage after spinal cord injury (SCI). Polyunsaturated fatty acids (PUFAs) play an important role in the onset and resolution of inflammation. Arachidonic acid (AA), an -6 PUFA, contributes to the initiation of inflammatory responses, whereas docosahexaenoic acid (DHA), an -3 PUFA, has antiinflammatory effects. Therefore, decreasing AA and increasing DHA levels after SCI might be expected to attenuate inflammation after SCI and promote tissue protection and functional recovery. We show here that daily oral administration of fenretinide after spinal cord contusion injury led to a significant decrease in AA and an increase in DHA levels in plasma and injured spinal cord tissue. This was accompanied by a significant reduction in tissue damage and improvement in locomotor recovery. Fenretinide also reduced the expression of proinflammatory genes and the levels of oxidative stress markers after SCI. In addition, in vitro studies demonstrated that fenretinide reduced TNF-␣ (tumor necrosis factor-␣) expression by reactive microglia. These results demonstrate that fenretinide treatment after SCI can reduce inflammation and tissue damage in the spinal cord and improve locomotor recovery. These beneficial effects may be mediated via the ability of fenretinide to modulate PUFA homeostasis. Since fenretinide is currently in clinical trials for the treatment of cancers, this drug might be a good candidate for the treatment of acute SCI in humans.

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“…Their degradation leads to aldehydes which react with amino-groups of proteins changing their structural and functional properties. 38,39 Sarsilmaz et al 2003 showed that treatment with n-3 FA decreased lipid peroxidation in corpus striatum in rats. Dietary supplementation with fish oil can increase antioxidative defense and reduce lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid Composition and Oxidative Stress Parameters in Plasma after Fish Oil Supplementation in Aging

et al. 2014

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Abstract. Fish oil affects oxidative stress parameters and changes in phospholipids fatty acids profiles in plasma, erythrocytes and tissues. We examined the effects of fish oil supplementation in young and old male Wistar rats (3 and 22 months old) on plasma phospholipids fatty acids profiles and blood oxidative stress parameters. Twenty young and twenty aged Wistar rats were randomly divided into four groups (ten animals each): two control groups and two supplemented groups treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid (EPA) and 30 mg docosahexanoic acid (DHA). Fish oil supplementation changed the percentage of long chain fatty acids (FAs): the elevated percentage of eicosatrienoic acid (ETA, 20:3), eicosapentanoic (EPA, 20:5), docosapentanoic acid (DPA, 22:5), n-3 fatty acids and decreased arachidonic acid (AA, 20:4). However, there were no age-related changes in total SH groups, the percentages of palmitic (16:0), palmitoleic (16:1), oleic (18:1 (n-9)) and linoleic acid (18:2) in plasma phospholipids and MUFA and they were neither reversed nor prevented by fish oil supplementation. Results showed that fish oil supplementation increased SOD and CAT activities in erythrocytes, and PON activity in the blood plasma of both young and aged rats. Furthermore, fish oil supplementation decreased lipid peroxidation (MDA) and nitrite levels in both young and aged rats implying better antioxidant protection and a lower level of oxidative pressure after fish oil supplementation. Our results suggest that fish oil supplementation is beneficial regarding better antioxidant protection in both young and aged rats, while applied treatment differs in plasma phospholipids FAs composition.

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Potential role of dietary ω-3 essential fatty acids on some oxidant/antioxidant parameters in rats’ corpus striatum

Cited by 104 publications

References 37 publications

The Effects of Hempseed Meal Intake and Linoleic Acid on Drosophila Models of Neurodegenerative Diseases and Hypercholesterolemia

The Effects of Hempseed Meal Intake and Linoleic Acid on Drosophila Models of Neurodegenerative Diseases and Hypercholesterolemia

Fenretinide Promotes Functional Recovery and Tissue Protection after Spinal Cord Contusion Injury in Mice

Fatty Acid Composition and Oxidative Stress Parameters in Plasma after Fish Oil Supplementation in Aging

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