Potential Role of Cuproptosis-Related Lncrna in Prognosis and Immunotherapy of Thyroid Carcinoma

Cai, Yunying; Niu, Ben; Gao, Jie; Su, Heng

doi:10.18502/ijph.v52i5.12718

Cited by 1 publication

(1 citation statement)

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“…Yet, it is still uncertain if cuproptosis triggers autophagy. The phenomenon of cuproptosis arises when an abundance of copper attaches to lipoylated proteins, causing the misfolding of mitochondrial proteins and possibly triggering mitophagy to preserve mitochondrial balance [ 24 , 49 ]. In this study, treatment with TTM enhanced the activation of mitophagy in macrophages stimulated by LPS, indicating that cuproptosis triggered by LPS stimulates mitophagy.…”

Section: Discussionmentioning

confidence: 99%

Copper Chelation Therapy Attenuates Periodontitis Inflammation through the Cuproptosis/Autophagy/Lysosome Axis

Zhang,

Tsai,

et al. 2024

IJMS

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Periodontitis development arises from the intricate interplay between bacterial biofilms and the host’s immune response, where macrophages serve pivotal roles in defense and tissue homeostasis. Here, we uncover the mitigative effect of copper chelator Tetrathiomolybdate (TTM) on periodontitis through inhibiting cuproptosis, a newly identified form of cell death which is dependent on copper. Our study reveals concurrent cuproptosis and a macrophage marker within murine models. In response to lipopolysaccharide (LPS) stimulation, macrophages exhibit elevated cuproptosis-associated markers, which are mitigated by the administration of TTM. TTM treatment enhances autophagosome expression and mitophagy-related gene expression, countering the LPS-induced inhibition of autophagy flux. TTM also attenuates the LPS-induced fusion of autophagosomes and lysosomes, the degradation of lysosomal acidic environments, lysosomal membrane permeability increase, and cathepsin B secretion. In mice with periodontitis, TTM reduces cuproptosis, enhances autophagy flux, and decreases Ctsb levels. Our findings underscore the crucial role of copper-chelating agent TTM in regulating the cuproptosis/mitophagy/lysosome pathway during periodontitis inflammation, suggesting TTM as a promising approach to alleviate macrophage dysfunction. Modulating cuproptosis through TTM treatment holds potential for periodontitis intervention.

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Section: Discussionmentioning

confidence: 99%