Potential role of cellular miRNAs in coronavirus-host interplay

Nersisyan, Stepan; Engibaryan, Narek; Gorbonos, Aleksandra; Kirdey, Ksenia; Makhonin, Alexey; Tonevitsky, Alexander G.

doi:10.7717/peerj.9994

Cited by 77 publications

(87 citation statements)

References 59 publications

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“… Russia To predict miRNA binding sites within human coronavirus RNAs using bioinformatic tools. ( Nersisyan et al, 2020a ) 10 Chow JT-S August 26, 2020. Canada To identify human miRNAs with the potential to target the SARS-CoV-2 genome and alterations of miRNA expression levels upon infection.…”

Section: Resultsmentioning

confidence: 99%

“… SARS-CoV-2 S gene Targets both SARS-CoV-2 and SARS isolates miR-197-5p SARS-CoV-2 ORF1a Upregulated in patients with cardiovascular disease Chow and Salmena, 2020 , Demirci and Adan, 2020 , Khan et al, 2020b , Rad and McLellan, 2020 . miR-21-3p Not reported Expressed in respiratory epithelial cells in the trachea and lung tissues Targets binding sites of 6 different coronavirus, including SARS-CoV-2 and SARS Fulzele et al, 2020 Haddad and Al-Zyoud, 2020 , Nersisyan et al, 2020a , Srivastava et al, 2020 . miR-323a-5p SARS-CoV-2 ORF1a/b Inhibits the translation of the ORF1a/b polyprotein gene Demirci and Adan, 2020 , Fulzele et al, 2020 , Khan et al, 2020b , Sardar et al, 2020 .…”

Section: Resultsmentioning

confidence: 99%

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The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

Marchi¹,

Sugita²,

Centa³

et al. 2021

Infection, Genetics and Evolution

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MicroRNAs are gene expression regulators, associated with several human pathologies, including the ones caused by virus infections. Although their role in infection diseases is not completely known, they can exert double functions in the infected cell, by mediating the virus infection and/or regulating the immunity-related gene targets through complex networks of virus-host cell interactions. In this systematic review, the Pubmed, EMBASE, Scopus, Lilacs, Scielo, and EBSCO databases were searched for research articles published until October 22nd, 2020 that focused on describing the role, function, and/or association of miRNAs in SARS-CoV-2 human infection and COVID-19. Following the PRISMA 2009 protocol, 29 original research articles were selected. Most of the studies reported miRNA data based on the genome sequencing of SARS-CoV-2 isolates and computational prediction analysis. The latter predicted, by at least one independent study, 1266 host miRNAs to target the viral genome. Thirteen miRNAs were identified by four independent studies to target SARS-CoV-2 specific genes, suggested to act by interfering with their cleavage and/or translation process. The studies selected also reported on viral and host miRNAs that targeted host genes, on the expression levels of miRNAs in biological specimens of COVID-19 patients, and on the impact of viral genome mutations on miRNA function. Also, miRNAs that regulate the expression levels of the ACE2 and TMPRSS2 proteins, which are critical for the virus entrance in the host cells, were reported. In conclusion, despite the limited number of studies identified, based on the search terms and eligibility criteria applied, this systematic review provides evidence on the impact of miRNAs on SARS-CoV-2 infection and COVID-19. Although most of the reported viral/host miRNAs interactions were based on in silico prediction analysis, they demonstrate the relevance of the viral/host miRNA interaction for viral activity and host responses. In addition, the identified studies highlight the potential use of miRNAs as therapeutic targets against COVID-19, and other viral human diseases (This review was registered at the International Prospective Register of Systematic Reviews (PROSPERO) database (#CRD42020199290).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

Marchi¹,

Sugita²,

Centa³

et al. 2021

Infection, Genetics and Evolution

View full text Add to dashboard Cite

show abstract

“…The sequestration of host-expressed miR-17 RNA by this pestivirus confers a functional de-repression of multiple cellular miR-17 targets and extensively modifies the host transcriptome [45]. Most recently, a computational study predicted that six human miRNAs (miR-21-3p, miR-195-5p, miR-16-5p, miR-3065-5p, miR-424-5p, and miR-421) may be able to bind to genomic RNAs of all seven human coronaviruses [15]. Because miR-21-3p expression is upregulated 8-fold in the lungs of mice infected with SARS-CoV-1, such proposed interactions with the virus appear very likely to affect the course of SARS-CoV-2 infection.…”

Section: Emerging Role Of Mirnas In Promoting Viral Diseasesmentioning

confidence: 99%

“…At present, it is unclear why coronaviruses do not eliminate the binding sites for the host miRNAs. The authors speculate that the miR-21-3p might slow down coronavirus replication in the early stages of infection and thus delay the activation of host's immune response [15]. Nonetheless, viral interaction with endogenous host miRNA represents an important aspect of viral pathogenesis that warrants much greater attention and study.…”

Section: Emerging Role Of Mirnas In Promoting Viral Diseasesmentioning

confidence: 99%

“…More recently, viruses have been shown capable of exploiting EVs to traffic in and out of cells and a rapidly growing literature implicate EVs as important mediators of the mechanisms orchestrating the viral manipulation of the host's immune system. Intriguingly, newly emerging findings suggest that coronaviruses can generate their own ncRNAs and involve host ncRNAs in virus infection [15][16][17][18][19]. Moreover, cells infected with coronaviruses may produce exosomes that can transfer angiotensin converting enzyme 2 (ACE2), the receptor for the SARS-Cov-2 entry, to other cells and thereby make them susceptible to virus docking [20].…”

Section: Introductionmentioning

confidence: 99%

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New Insights on the Mobility of Viral and Host Non-Coding RNAs Reveal Extracellular Vesicles as Intriguing Candidate Antiviral Targets

2020

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Intercellular communication occurring by cell-to-cell contacts and via secreted messengers trafficked through extracellular vehicles is critical for regulating biological functions of multicellular organisms. Recent research has revealed that non-coding RNAs can be found in extracellular vesicles consistent with a functional importance of these molecular vehicles in virus propagation and suggesting that these essential membrane-bound bodies can be highjacked by viruses to promote disease pathogenesis. Newly emerging evidence that coronaviruses generate non-coding RNAs and use extracellular vesicles to facilitate viral pathogenicity may have important implications for the development of effective strategies to combat COVID-19, a disease caused by infection with the novel coronavirus, SARS-CoV-2. This article provides a short overview of our current understanding of the interactions between non-coding RNAs and extracellular vesicles and highlights recent research which supports these interactions as potential therapeutic targets in the development of novel antiviral therapies.

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miRNAs; a novel strategy for the treatment of COVID‐19

Hao

Ebrahimi

Keivan

et al. 2021

Cell Biology International

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Coronavirus disease 2019 (COVID‐19) is the seventh member of the bat severe acute respiratory syndrome family. COVID‐19 can fuse their envelopes with the host cell membranes and deliver their genetic material. COVID‐19 attacks the respiratory system and stimulates the host inflammatory responses, enhances the recruitment of immune cells, and promotes angiotensin‐converting enzyme 2 activities. Patients with confirmed COVID‐19 may have experienced fever, dry cough, headache, dyspnea, acute kidney injury, acute respiratory distress syndrome, and acute heart injury. Several strategies such as oxygen therapy, ventilation, antibiotic or antiviral therapy, and renal replacement therapy are commonly used to decrease COVID‐19‐associated mortality. However, these approaches may not be good treatment options. Therefore, the search for an alternative‐novel therapy is urgently important to prevent the disease progression. Recently, microRNAs (miRNAs) have emerged as a promising strategy for COVID‐19. The design of oligonucleotide against the genetic material of COVID‐19 might suppress virus RNA translation. Several previous studies have shown that host miRNAs play an antiviral role and improve the treatment of patients with COVID‐19. miRNAs by binding to the 3′‐untranslated region (UTR) or 5′‐UTR of viral RNA play an important role in COVID‐19‐host interplay and viral replication. miRNAs interact with multiple pathways and reduce inflammatory biomarkers, thrombi formation, and tissue damage to accelerate the patient outcome. The information in this review provides a summary of the current clinical application of miRNAs for the treatments of patients with COVID‐19.

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Potential role of cellular miRNAs in coronavirus-host interplay

Cited by 77 publications

References 59 publications

The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

New Insights on the Mobility of Viral and Host Non-Coding RNAs Reveal Extracellular Vesicles as Intriguing Candidate Antiviral Targets

miRNAs; a novel strategy for the treatment of COVID‐19

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