Potential role of bioactive compounds of Phaseolus vulgaris L. on lipid-lowering mechanisms

Ramírez‐Jiménez, Aurea K.; Reynoso‐Camacho, Rosalía; Tejero, M. Elizabeth; León-Galván, Ma. Fabiola; Loarca-Piña, Guadalupe

doi:10.1016/j.foodres.2015.01.002

Cited by 53 publications

(45 citation statements)

References 138 publications

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“…They are secreted by the plant as a part of the defense mechanism [54,55]. Human beings use these agents for many beneficial purposes.…”

Section: Antinutrientsmentioning

confidence: 99%

“…Lectins have high binding capacity to the intestinal brush border membrane. This stimulates the release of anorectic neuropeptides that produce satiety and decrease food intake [55]. However, lectins can cause severe intestinal damage with disrupting digestion provoking food allergies and other immune responses [55].…”

Section: Antinutrientsmentioning

confidence: 99%

“…This stimulates the release of anorectic neuropeptides that produce satiety and decrease food intake [55]. However, lectins can cause severe intestinal damage with disrupting digestion provoking food allergies and other immune responses [55]. Saponins are amphipathic antinutrients which can reduce cholesterol absorption by disruption of cholesterol micelle formation and downregulate the activity of lipogenic enzymes [54,55].…”

Section: Antinutrientsmentioning

confidence: 99%

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Natural Cholesterol Busters

Harisa¹,

Attia²,

Allah³

2016

Cholesterol Lowering Therapies and Drugs

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Hypercholesterolemia, a risk factor for cardiovascular and cerebrovascular diseases, is a silent health problem. It occurs due to buildup of large amount of cholesterol in blood vessels resulting in narrowed blood vessels or blockage of the flow of blood and causes cellular dysfunction. The predisposing factors for hypercholesterolemia are carbohydrates-enriched diet, unhealthy fats, and red meat. Moreover, family history, obesity, hypokinetic lifestyle, aging, and oxidative stress are associated with hypercholesterolemia. Therapeutic interventions of hypercholesterolemia involve cessation of bad habits, regular exercise, consumption of cholesterol buster diets, and cholesterollowering drugs. However, cholesterol-lowering drugs have low efficacy, and some patients cannot tolerate the adverse effects of hypocholesterolemic drugs. In light of this, there has been great interest to address natural cholesterol busters as first choice as cholesterol-lowering option. Healthy diet, regular exercise and natural cholesterollowering agents are documented to decrease blood cholesterol level. Natural cholesterol busters include dietary fibers, plant sterols, healthy fats, smart proteins, antinutrients, antioxidants, and L-arginine. These busters not only decrease cholesterol oxidation and absorption but also increase cholesterol catabolism and elimination. Most of these busters are found in cereals, oatmeal, fruits, vegetables, legumes, and fermented foods. The natural cholesterol busters are recommended strategies for treatment of hypercholesterolemia alone or in combination with cholesterol-lowering drugs.

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“…They are secreted by the plant as a part of the defense mechanism [54,55]. Human beings use these agents for many beneficial purposes.…”

Section: Antinutrientsmentioning

confidence: 99%

Section: Antinutrientsmentioning

confidence: 99%

Section: Antinutrientsmentioning

confidence: 99%

See 1 more Smart Citation

Natural Cholesterol Busters

Harisa¹,

Attia²,

Allah³

2016

Cholesterol Lowering Therapies and Drugs

View full text Add to dashboard Cite

show abstract

“…Normalmente entre a concentração de AGCC produzidos, encontra-se o ácido acético em maior quantidade, seguido do ácido propiônico e em menor ou igual quantidade, o ácido butírico, numa proporção molar média de 60:20:20, podendo variar de acordo com a composição dietética (WONG et al, 2006 WONG et al, 2006;RAMÍREZ-JIMÉNEZ, 2015). O ácido acético pode auxiliar na diminuição da síntese hepática de ácidos graxos, uma vez que não é substrato para a lipogênese.…”

Section: Lipídeos Totais E Colesterol No Fígadounclassified

“…Sugere-se que a grande proporção de acido acético gerado após a fermentação das fibras alimentares e amido resistente resulta em diminuição da produção de ácidos graxos livres, que por sua vez diminui as concentrações de triglicerídeos circulantes (RAMÍREZ-JIMÉNEZ, 2015).…”

Section: Lipídeos Totais E Colesterol No Fígadounclassified