Potential Role of Aromatase over Estrogen Receptor Gene Polymorphisms in Migraine Susceptibility: A Case Control Study from North India

Ghosh, Jayashri; Joshi, Gunjan; Pradhan, Sunil; Mittal, Balraj

doi:10.1371/journal.pone.0034828

Cited by 23 publications

(31 citation statements)

References 32 publications

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“…A meta-analysis of estrogen polymorphism studies indicates that two variants, ESR-1 594G> A and 325C> G, increase the risk for migraine 40-60% (99). Challenging that study, however, recent evidence indicates that aromatase polymorphisms (CYP19A1 rs10046 and CYP19A1 rs4646) also confer a risk for migraine and its protective effect, respectively, and may be more significant than estrogen polymorphisms (100). The latter hypothesis is supported by a twin study indicating that environmental and genetic factors have comparable contributions to migraine (101).…”

Section: Hypothalamic Role In Hormonal Regulation Of Brain Dysmetria mentioning

confidence: 84%

Sex and the migraine brain

Borsook

Erpelding

Lebel

et al. 2014

Neurobiology of Disease

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The brain responds differently to environmental and internal signals that relates to the stage of development of neural systems. While genetic and epigenetic factors contribute to a premorbid state, hormonal fluctuations in women may alter the set point of migraine. The cyclic surges of gonadal hormones may directly alter neuronal, glial and astrocyte function throughout the brain. Estrogen is mainly excitatory and progesterone inhibitory on brain neuronal systems. These changes contribute to the allostatic load of the migraine condition that most notably starts at puberty in girls.

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Section: Hypothalamic Role In Hormonal Regulation Of Brain Dysmetria mentioning

confidence: 84%

Sex and the migraine brain

Borsook

Erpelding

Lebel

et al. 2014

Neurobiology of Disease

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“…The ESR1 rs2228480 (A allele) may be associated with an increase in migraine susceptibility in Caucasian populations, and it was also associated with increased coronary intima media thickness in women, suggesting an increased susceptibility to cardiovascular disease . A link between migraine and the rs10046 and rs4646 polymorphisms in the estrogen producing enzyme CYP19A1 has been demonstrated …”

Section: Hypercoagulable States In Migrainementioning

confidence: 99%

“…24 A link between migraine and the rs10046 and rs4646 polymorphisms in the estrogen producing enzyme CYP19A1 has been demonstrated. 25,26 Platelet Changes…”

Section: Hypercoagulable States In Migraine High Estrogen Statesmentioning

confidence: 99%

Hypercoagulability and Migraine

Tietjen

Collins

2017

Headache

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Background.-A growing body of literature suggests that migraineurs, particularly those with aura, have an increased risk for ischemic stroke, but not via enhanced atherosclerosis. The theory that micro-emboli induced ischemia provokes cortical spreading depression (ie, symptomatic aura) in migraineurs but transient ischemic attacks in others highlights a potential role for hypercoagulability as a link between migraine (with aura) and stroke.Aim.-Our objective is to summarize the literature evaluating the association of migraine with various acquired or inheritable thrombophilic states, including those related to elevated estrogen levels, endothelial activation and dysfunction, antiphospholipid antibodies (aPL), deficiency of coagulation inhibitors, and presence of certain genetic polymorphisms.Findings.-Although definitive studies are lacking, a preponderance of available evidence links migraine, and especially aura, to increased levels of estradiol (eg, oral contraceptive pill [OCP] use, pregnancy), thrombo-and erythrocytosis, von Willebrand factor (vWF) antigen, fibrinogen, tissue plasminogen activator (tPA) antigen, and endothelial microparticles. Studies of a link to migraine are conflicting for aPL, homocysteine, Protein S, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism. No association with migraine was found in meta-analyses of Factor V Leiden, and of prothrombin gene mutation. Within a large, young ischemic stroke sample, migraine with aura was associated with a thrombophilic state and with patent foramen ovale (PFO). In the non-stroke population, meta-analyses show an association of PFO and migraine with aura (MA), but two populationbased studies do not support the link.Recommendations.-For persons with MA and (1) a personal history or family history of thrombosis, or (2) MRI evidence of micro-vascular ischemia or of stroke, an evaluation for hypercoagulability is warranted. In cases of MA alone, consider screening for markers of endothelial activation (eg, vWF, high sensitivity c-reactive protein [hs CRP], and fibrinogen). Rigorous management of other stroke risk factors is paramount, but efficacy of anti-thrombotic agents in the treatment of migraine is unproven. Closure of PFO is not routinely recommended based on negative randomized trials.

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“…However, the extensive research fail to reach a consensus with respect to the inherent susceptibility to migraine associated with ESR1 gene polymorphisms. 16 – 21 The small numbers and varying populations of the published studies may partially account for the controversial results. The most important reason that promotes us to perform the present meta-analysis is the less reliable discoveries of an earlier analysis as a result of overlapped data 22 and the new information from recent publications.…”

Section: Introductionmentioning

confidence: 99%

Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility

Liu

Zhao

et al. 2015

Medicine

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An increasing number of studies have explored genetic associations between the functionally important polymorphisms in estrogen receptor 1 (ESR1) gene and migraine susceptibility. The previously reported associations have nevertheless been inconsistent.The present work incorporating the published data derived from 8 publications was performed to assess the impact of these polymorphisms on incident migraine. Strength of the genetic risk was estimated by means of an odds ratio along with the 95% confidence interval (OR and 95% CI).From the results, we found individuals who harbored the 325-GG genotype, compared with those harboring the CC genotype or CG and CC combined genotypes, had almost 50% greater risk of migraine. The same genetic models showed notable associations in subgroups of Caucasians and migraine with aura (MA). For 594G>A, a moderately increased risk of migraine was seen under AG versus GG. The AA + AG versus GG model, however, showed a borderline association with migraine. Subgroup analyses according to ethnicity and subtype of migraine provided statistical evidence of significantly increased risk of migraine in Caucasians and of a marginal association with MA, respectively. Both 325C>G and 594G>A polymorphisms showed no major effects either in males or in females.Based on the statistical data, we conclude some of the ESR1 gene polymorphisms may have major contributions to the pathogenesis of migraine in Caucasian populations.

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Potential Role of Aromatase over Estrogen Receptor Gene Polymorphisms in Migraine Susceptibility: A Case Control Study from North India

Cited by 23 publications

References 32 publications

Sex and the migraine brain

Sex and the migraine brain

Hypercoagulability and Migraine

Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility

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