Potential risks of phytonutrients associated with high-dose or long-term use

Süntar, İpek; Yakıncı, Ömer Faruk

doi:10.1016/b978-0-12-815354-3.00010-1

Cited by 13 publications

(9 citation statements)

References 86 publications

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“…Interestingly, whole plants or different parts of plants have been used in traditional medicine since the beginning of human evolution for the treatment of various diseases. Because of their antioxidant and anti-inflammatory properties, phytochemicals played and are still playing an essential role in the discovery and development of several drugs, according to preclinical, clinical, and epidemiological studies [ 72 ]. However, some phytochemicals can cause acute and chronic adverse effects, and even promote cancer [ 73 ].…”

Section: Alternatives To Antibiotics As Growth Promotersmentioning

confidence: 99%

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

2022

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The overuse and misuse of antibiotics has contributed to the rise and spread of multidrug-resistant bacteria. To address this global public health threat, many countries have restricted the use of antibiotics as growth promoters and promoted the development of alternatives to antibiotics in human and veterinary medicine and animal farming. In food-animal production, acidifiers, bacteriophages, enzymes, phytochemicals, probiotics, prebiotics, and antimicrobial peptides have shown hallmarks as alternatives to antibiotics. This review reports the current state of these alternatives as growth-promoting factors for poultry and swine production and describes their mode of action. Recent findings on their usefulness and the factors that presently hinder their broader use in animal food production are identified by SWOT (strength, weakness, opportunity, and threat) analysis. The potential for resistance development as well as co- and cross-resistance with currently used antibiotics is also discussed. Using predetermined keywords, we searched specialized databases including Scopus, Web of Science, and Google Scholar. Antibiotic resistance cannot be stopped, but its spreading can certainly be hindered or delayed with the development of more alternatives with innovative modes of action and a wise and careful use of antimicrobials in a One Health approach.

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Section: Alternatives To Antibiotics As Growth Promotersmentioning

confidence: 99%

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

2022

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“…84 Similar to collagen and gelatin hydrolysates, recent epidemiological and experimental studies showed that it can also induce cancer in a dosage-dependent manner. For example, in a randomized and double-blind intervention trial, the β-carotene supplement (20 mg/d) group was found to have a higher risk of lung and gastric cancers in smokers, 145,146 which suggests that βcarotene supplement should not be consumed by smokers.…”

Section: Acs Foodmentioning

confidence: 99%

“…Iron also plays an essential role in cancer cell proliferation, metabolism, and metastasis, especially in oxygen transport and electron transfer due to its redox property. 146 Some iron-seeking phenotypes of cancer cells might be affected through downregulating iron metabolic proteins and associated death pathways, such as ferroptosis, known as an Fe-dependent form of cell mortality. Paradoxically, both Fe-depletion and Fesupplementation are able to be utilized in anti-cancer therapy.…”

Section: Acs Foodmentioning

confidence: 99%

Cancer Prevention Effects of Foods, Food Groups, Nutrients, and Their Underlying Mechanisms

Xia

Yang

Liang

et al. 2022

ACS Food Sci. Technol.

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Cancer, the second leading cause of death around the world, imposes a heavy socioeconomic burden to both developing and developed countries. Among the identified carcinogenic risk factors, dietary intake accounts for over 35% of prostate, colorectal, pancreatic, gall bladder, breast, endometrial, and gastric cancers, which might be prevented by adjusting food intake alone. Therefore, preventing cancer through modifying food intake is a cost-effective measure with few side effects. For some cancer patients, this might relieve their pain as well. Previous studies have focused on the preventative effect of multiple dietary combinations for certain types of cancer, which laid the foundation for health organizations to compile dietary guidelines to prevent cancers. Emerging evidence also suggests that diets rich in fruits and vegetables are more effective in cancer prevention than individual micronutrients. However, the underlying mechanisms and possible interactions with chemotherapies have not been comprehensively investigated. This mini-review summarizes recent preclinical, clinical, and epidemiological evidence of the promotive or preventative effect of foods, food groups, and nutrients on carcinogenesis, as well as their possible molecular mechanisms, including high calorie diets and red meats, bioactive proteins in milk, fish, and soy, macro-phyto-chemicals (anthocyanins, catechin, procyanidins, gallic acids, ellagic acid, lignans, curcumins, resveratrol, β-carotene, lycopene, sulforaphane, indole-3-carbinol, and proanthocyanidin), micronutrients (vitamins, minerals), and fatty acids. Their potential underlying chemopreventive mechanisms will also be discussed. This might serve as a reference for professionals who research on cancer or manage cancer patients and the general public who would like to prevent cancer through changing their diets.

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“…FRs sustain tumor cell proliferation, migration, and invasion, and their levels impact the CRC patient’s average life expectancy [ 103 , 104 ]. FRs bind folate, a water-soluble vitamin involved in amino acid metabolism and DNA and RNA synthesis [ 105 ], with a vital role in cell survival and proper development. In cancers, the overexpression of FRs leads to an increased intracellular concentration of folate, a nutrient that sustains the rapid and uncontrolled tumor cell proliferation [ 106 , 107 ].…”

Section: Targeting Strategies For Drug-delivery Systems In Crcmentioning

confidence: 99%

Current Landscape in Organic Nanosized Materials Advances for Improved Management of Colorectal Cancer Patients

et al. 2021

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Globally, colorectal cancer (CRC) ranks as one of the most prevalent types of cancers at the moment, being the second cause of cancer-related deaths. The CRC chemotherapy backbone is represented by 5-fluorouracil, oxaliplatin, irinotecan, and their combinations, but their administration presents several serious disadvantages, such as poor bioavailability, lack of tumor specificity, and susceptibility to multidrug resistance. To address these limitations, nanomedicine has arisen as a powerful tool to improve current chemotherapy since nanosized carriers hold great promise in improving the stability and solubility of the drug payload and enhancing the active concentration of the drug that reaches the tumor tissue, increasing, therefore, the safety and efficacy of the treatment. In this context, the present review offers an overview of the most recent advances in the development of nanosized drug-delivery systems as smart therapeutic tools in CRC management and highlights the emerging need for improving the existing in vitro cancer models to reduce animal testing and increase the success of nanomedicine in clinical trials.

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Potential risks of phytonutrients associated with high-dose or long-term use

Cited by 13 publications

References 86 publications

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

Insights in the Development and Uses of Alternatives to Antibiotic Growth Promoters in Poultry and Swine Production

Cancer Prevention Effects of Foods, Food Groups, Nutrients, and Their Underlying Mechanisms

Current Landscape in Organic Nanosized Materials Advances for Improved Management of Colorectal Cancer Patients

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