Potential risk of blood transfusion‐transmitted brucellosis in an endemic area of <scp>C</scp>hina

Wang, Wenjing; Liao, Qimei; Wu, Xiaoxia; Hou, Shuiping; Wang, Yuanzhi; Wu, Jingbo; Shen, Chuanwei; Chen, Shouyi; Allain, Jean‐Pierre; Li, Chengyao

doi:10.1111/trf.12853

Cited by 26 publications

(18 citation statements)

References 37 publications

(77 reference statements)

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“…being affected by brucellosis, it is one of the most widespread zoonosis in the world [1]. Possible routes of acquisition of brucellosis include consumption of derived food products such as unpasteurized milk and cheese, contact with infectious secretions from animals, and rarely human to human transmission through blood transfusion, sexual contact and organ transplantation [2,3].…”

Section: Introductionmentioning

confidence: 99%

High index of suspicion for brucellosis in a highly cosmopolitan city in southern China

et al. 2020

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Background: Brucellosis is one of the most widespread zoonosis in the world. In China, 90% of human brucellosis occurs in six northern agricultural provinces. However, there is a recent increase in the trend of human brucellosis in southern provinces with limited cases reported in the literature. Our study aims to describe the clinical features and epidemiology of brucellosis in a tertiary hospital in southern China. Methods: A retrospective case series of brucellosis was conducted between January 1, 2014 and October 31. 2018. Cases were identified based on positive Brucella serology by tube agglutination test, or positive culture from clinical specimen identified by Vitek 2 and MALDL-TOF MS. Clinical details of brucellosis including patients' occupation, risk factors, and complications were analyzed. Clinical characteristics between patients from Guangdong and other provinces were also compared. Results: A total of 13 cases of laboratory-confirmed brucellosis were identified. 7 (53.8%) of the patients were male, 6 (46.2%) were female, with age ranging from 29 to 73 years old (median age: 51 years). 5 patients (38.5%) were from Guangdong province, while the remaining patients (61.5%) were from other provinces. The commonest risk factors of acquisition were consumption of undercooked meat and goat placenta. Patients from Guangdong province were found to be more likely to have prior placenta consumption. The commonest clinical presentations were fever, osteoarticular pain, urinary symptoms, splenomegaly, and lymphadenopathy. Spondylodiscitis/ peripheral joint arthritis (5 patients, 38.5%) was the most prevalent complication, while extra-osteoarticular complications including abdominal aortitis, hepatosplenic abscess, chest wall abscess, and epididymo-orchitis were observed in 4 other patients. Furthermore, it was demonstrated that MALDI-TOF MS is reliable in Brucella identification after additional of reference spectra with standard Brucella strain. Conclusions: Brucellosis, previously thought to be only found in northern China, is now increasingly seen in highly cosmopolitan part of southern China. MALDI-TOF MS in hospitals in China should include reference spectra with standard Brucella strain to aid bacterial identification in routine clinical practice. In addition to tuberculosis, typhoid fever and typhus, brucellosis should be considered in patients with fever of unknown origin in this locality.

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Section: Introductionmentioning

confidence: 99%

High index of suspicion for brucellosis in a highly cosmopolitan city in southern China

et al. 2020

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“…Despite malaria being endemic in some regions of China and previous reports of at least 87 cases transmitted by transfusion from 1992 to 2015 [12], the prevalence of malarial parasites in blood donors is unknown and screening of blood is not [13]. SFTSV, a tick-borne bunyavirus, was first described in China concentrated in the mountainous rural areas in central-eastern China with episodic outbreaks from spring to autumn.…”

Section: Chinamentioning

confidence: 99%

Blood Transfusion-Associated Infections in the Twenty-First Century: New Challenges

Fong

2020

Current Trends and Concerns in Infectious Diseases

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“…Recently, a Brucella spp. investigation based on enzyme immunoassay testing among blood donors in an endemic area (Kashi, Xinjiang province) showed that the reactive rate was 1% (39/3896), in which 0.64% (25/3896) samples were further confirmed by western blot (WB) testing, and the Brucella DNA prevalence rate was 0.39% (15/3896) [105]. Although no infection cases transmitted by transfusion have been reported, the existence of Brucella DNA in donors' plasma samples indicates potential risk of transfusion-transmitted brucellosis in endemic areas and warrants future investigation.…”

Section: Brucellamentioning

confidence: 99%

The Impact of Emerging Infectious Diseases on Chinese Blood Safety

Wang

Chen

et al. 2017

Transfusion Medicine Reviews

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Emerging infectious diseases (EIDs) have always been one of the major threats to public health. Although the implementation of mandatory testing for 4 classical transfusion-transmitted infectious-human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and syphilis-has reduced the transfusion risk of these pathogens, the potential threat of various EID agents and their constantly evolving variants to blood safety in China is not fully understood. This review presents 9 representative EID agents that are autochthonous and epidemic nationally or regionally in China. The epidemiologic status and distribution of these EID agents among donors and/or healthy populations are summarized. The potential risks of these EID agents to blood safety are discussed. The review also explores strategies to strengthen hemovigilance systems and studies to further evaluate the impact of EID agents on blood safety.

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Potential risk of blood transfusion‐transmitted brucellosis in an endemic area of China

Abstract: The data indicate a probable high rate of Brucella bacteremia, suggesting a potential risk of transfusion-transmitted brucellosis. Blood donation screening for Brucella infection may be considered in the high Brucella-endemic areas of China.

Cited by 26 publications

References 37 publications

High index of suspicion for brucellosis in a highly cosmopolitan city in southern China

High index of suspicion for brucellosis in a highly cosmopolitan city in southern China

Blood Transfusion-Associated Infections in the Twenty-First Century: New Challenges

The Impact of Emerging Infectious Diseases on Chinese Blood Safety

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