Potential Relationships Between NAFLD Fibrosis Score and Graft Status in Liver Transplant Patients

Abstract

Liver transplantation is the only definitive treatment for patients with end-stage liver disease. 1 Increase in the incidence of non-alcoholic fatty liver disease (NAFLD)-related liver failure has caused it to become one of the most common reasons for liver transplantation. The severity of the disease itself can range from hepatic steatosis (lipid retention in the liver) to steatohepatitis (lipid retention coupled with inflammation of liver tissue), and it can lead to advanced cirrhosis and hepatocellular carcinoma, among other ill sequelae. 1 The decision to use a liver from a deceased donor for transplantation into a recipient depends on histopathological, Figure 1: Different levels of fibrosis in liver parenchyma. This image shows the five accepted stages of fibrosis common in pathological analysis of liver fibrosis scoring, F0-F4.