Potential relationship between Sirt3 and autophagy in ovarian cancer (Review)

Abstract

Sirtuin 3 (Sirt3) is an important member of the sirtuin protein family. It is a deacetylase that was previously reported to modulate the level of reactive oxygen species (ROS) production and limit the extent of oxidative damage in cellular components. As an important member of the class III type of histone deacetylases, Sirt3 has also been documented to mediate nuclear gene expression, metabolic control, neuroprotection, cell cycle and proliferation. In ovarian cancer (OC), Sirt3 has been reported to regulate cellular metabolism, apoptosis and autophagy. Sirt3 can regulate autophagy through a variety of different molecular signaling pathways, including the p62, 5'AMP-activated protein kinase and mitochondrial ROS-superoxide dismutase pathways. However, autophagy downstream of Sirt3 and its association with OC remains poorly understood. In the present review, the known characteristics of Sirt3 and autophagy were outlined, and their potential functional roles were discussed. Following a comprehensive analysis of the current literature, Sirt3 and autophagy may either serve positive or negative roles in the regulation of OC. Therefore, it is important to identify the appropriate expression level of Sirt3 to control the activation of autophagy in OC cells. This strategy may prove to be a novel therapeutic method to reduce the mortality of patients with OC. Finally, potential research directions into the association between Sirt3 and other signaling pathways were provided.

COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied?

“…Similarly, an increased activation of inflammasome and its contribution to chronic inflammation has been demonstrated in malignant ovarian cancer [ 130 ]. Aging is characterized by ROS-mediated mitochondrial damage, an increase in iron deposition, deregulation of Ca 2+ and postabsorptive plasma cysteine homeostasis, as well as impaired autophagy and sirtuin activity secondary to aberrant insulin receptor signaling; events that are observed also in advanced ovarian cancer [ 131 – 133 ]. These altered pathways influence progressive increases in intracellular ROS level and oxidative stress [ 134 ].…”

Resveratrol reverses TGF‐β1‐mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis

“…Zhou et al found that Resv could attenuate the oxidative damage of endothelial cells by activating the SIRT3/AMPK pathway to regulate mitochondrial reactive oxygen species homeostasis (Zhou et al, 2014). Moreover, SIRT3 can modulate autophagy in cancer cells (Shi et al, 2020; Wei et al, 2018). Consistent with previous studies, Resv could both activation of SIRT1 and SIRT3, although the effect of SIRT1 on autophagy was unnoticeable.…”

Cancer‐associated fibroblast‐secreted miR‐421 promotes pancreatic cancer by regulating the SIRT3/H3K9Ac/HIF‐1α axis

“…As a vital member of class III histone deacetylases, SIRT3 mediates nuclear gene expression and cell proliferation. 27 Low expression of SIRT3 contributes to the progression, development, and poor prognosis of human PC. 28 SIRT3 is involved in the carcinogenic activity of miR-708-5p in pancreatic ductal adenocarcinoma cells.…”