Potential regulatory mechanisms of lncRNA in diabetes and its complications

Abstract

Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides without protein-coding potential. Although these molecules were initially considered as "junk products" of transcription without biological relevance, recent advances in research have shown that lncRNA plays an important role, not only in cellular processes such as proliferation, differentiation, and metabolism, but also in the pathological processes of cancers, diabetes, and neurodegenerative diseases. In this review, we focus on the potential regulatory roles of lncRNA in diabetes and the complications associated with diabetes.

<p>Microarray Analysis of Long Non-Coding RNAs in Lung Tissues of Patients with COPD and HOXA-AS2 Promotes HPMECs Proliferation via Notch1</p>

“…[23][24][25] Moreover, the dysregulation of lncRNAs is associated with pathological processes of different diseases, such as cardiovascular diseases, metabolic diseases, and cancer. [26][27][28] However, the role that lncRNAs plays in COPD pathogenesis remains to be determined. To address this problem, we used microarray analysis to study the differential expression of lncRNAs in COPD and non-COPD lung tissues.…”

The Construction and Analysis of the Aberrant lncRNA-miRNA-mRNA Network in Adipose Tissue from Type 2 Diabetes Individuals with Obesity

“…lncRNAs are generally considered to be important regulators of adipogenesis and adipocyte metabolism [13][14][15][16][17]. lncRNAs also play a role in the pathogenesis of T2DM and T2DM-related complications [18][19][20][21][22][23][24]. Competitive endogenous RNA (ceRNA) was first proposed by Salmena et al [25] and was defined as a class of noncoding RNAs that bind to miRNA.…”

<p>Long Non-Coding RNAs Regulate Inflammation in Diabetic Peripheral Neuropathy by Acting as ceRNAs Targeting miR-146a-5p</p>

“…4 It has been reported that lncRNAs are involved in the pathogenesis of DM and diabetic complications. 23 LncRNAs are endogenous regulators and play vital roles in various pathophysiological processes, which can regulate gene expression through competitively binding to miRNA at the post-transcriptional level. Several studies have confirmed that lncRNAs widely contribute to the pathophysiology process of DM and diabetic complications by acting as ceNRAs.…”