Potential Protective Role of Blood Pressure-Lowering Drugs on the Balance between Hemostasis and Fibrinolysis in Hypertensive Patients at Rest and During Exercise

Braschi, Annabella

doi:10.1007/s40256-018-00316-2

Cited by 6 publications

(3 citation statements)

References 523 publications

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“…Felodipine is capable of controlling the blood pressure by blocking the calcium channels, so it can be a proper option for curing both the mild and minor HT [53]. To treat HT, instead of proposing Felodipine, algorithms have acquired a list of medications which include Pinaverium.…”

Section: Resultsmentioning

confidence: 99%

Synthetic repurposing of drugs against hypertension: a datamining method based on association rules and a novel discrete algorithm

Masoudi-Sobhanzadeh

Masoudi‐Nejad

2020

BMC Bioinformatics

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Background: Drug repurposing aims to detect the new therapeutic benefits of the existing drugs and reduce the spent time and cost of the drug development projects. The synthetic repurposing of drugs may prove to be more useful than the single repurposing in terms of reducing toxicity and enhancing efficacy. However, the researchers have not given it serious consideration. To address the issue, a novel datamining method is introduced and applied to repositioning of drugs for hypertension (HT) which is a serious medical condition and needs some improved treatment plans to help treat it. Results: A novel two-step data mining method, which is based on the If-Then association rules as well as a novel discrete optimization algorithm, was introduced and applied to the synthetic repurposing of drugs for HT. The required data were also extracted from DrugBank, KEGG, and DrugR+ databases. The findings indicated that based on the different statistical criteria, the proposed method outperformed the other state-of-the-art approaches. In contrast to the previously proposed methods which had failed to discover a list on some datasets, our method could find a combination list for all of them. Conclusion: Since the proposed synthetic method uses medications in small dosages, it might revive some failed drug development projects and put forward a suitable plan for treating different diseases such as COVID-19 and HT. It is also worth noting that applying efficient computational methods helps to produce better results.

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Section: Resultsmentioning

confidence: 99%

Synthetic repurposing of drugs against hypertension: a datamining method based on association rules and a novel discrete algorithm

Masoudi-Sobhanzadeh

Masoudi‐Nejad

2020

BMC Bioinformatics

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“…The previous studies found doxaben treatment for chronic IS patients with hypertension increased cerebral blood flow that reduced recurrent IS [ 5 ]. A past study of hypertension treated with doxaben in Chinese patients compared to diuretic treatment decreased lipid levels [ 11 ] and normalized platelet function [ 12 ]. Aggressive antiplatelet and lipid-lowering agent prescriptions for IS patients that can reduce coronary artery disease correlated to recurrent IS.…”

Section: Discussionmentioning

confidence: 99%

Increased One-Year Recurrent Ischemic Stroke after First-Ever Ischemic Stroke in Males with Benign Prostatic Hyperplasia

Cheng

Chu

Lee

et al. 2020

IJERPH

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(1) Background: Patients with benign prostatic hyperplasia (BPH) were questioned about quality of life and sleep. Most BPH patients were treated with alpha-1 adrenergic receptor antagonists, which could improve cerebral blood flow for 1–2 months. Patients with ischemic stroke (IS) could experience cerebral autoregulation impairment for six months. The relationship between BPH and recurrent IS remains unclear. The aim of this study was to determine the risk of one-year recurrent IS conferred by BPH. (2) Methods: We used data from the Taiwanese National Health Insurance Database to identify newly diagnosed IS cases entered from 1 January 2008 to 31 December 2008. Patients were followed until the recurrent IS event or 365 days after the first hospitalization. The risk factors associated with one-year recurrent IS were assessed using Cox proportional hazards regression. (3) Results: Patients with BPH had a higher risk of recurrent IS (12.11% versus 8.15%) (adjusted hazard ratio (HR): 1.352; 95% confidence interval (CI): 1.028–1.78, p = 0.031). Other risk factors included hyperlipidemia (adjusted HR: 1.338; 95% CI: 1.022–1.751, p = 0.034), coronary artery disease (adjusted HR: 1.487; 95% CI: 1.128–1.961, p = 0.005), chronic obstructive pulmonary disease (adjusted HR: 1.499; 95% CI: 1.075–2.091, p = 0.017), and chronic kidney disease (adjusted HR: 1.523; 95% CI: 1.033–2.244, p = 0.033). (4) Conclusion: Patients with BPH who had these risk factors had an increased risk of one-year recurrent IS. The modification of risk factors may prevent recurrent IS.

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“…Age-related vascular in ammation and platelet hyperactivity are linked to cardiovascular events [4,5]. Platelet hyperactivity has been associated with several chronic diseases, including hypertension, diabetes, and hyperlipidemia [6][7][8]. Platelet activation is involved in thrombosis and promotes chronic in ammation and vascular injury in atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of Fruitflow on platelet function: a randomized placebo-controlled trial in elderly subjects

Chen¹,

Zhang

Wang

et al. 2021

Preprint

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Background: The elderly has a high risk of cardiovascular disease, which is often accompanied by platelet hyperactivity. Tomato extracts can inhibit platelet activation and have beneficial health effects. We aimed to investigate the effect of Fruitflow® (FF), a water-soluble tomato extract, on platelet function in elderly participants.Methods: This randomized group study was conducted with people over 50 years old. The participants were randomly divided into four groups: placebo (150 mg/day), FF (150 mg/day), acetylsalicylic acid (ASA; 100 mg/day), and FF (150 mg/day) + ASA (100 mg/day). These groups received the respective supplements after dinner daily for 7 days. Fasting blood was collected from the participants on days 0 and 8 to analyze platelet aggregation and the content of thromboxane B2 (TXB2), 6-keto-prostaglandin F1α, and platelet factor 4 (PF4). Results: One hundred ninety elderly participants were recruited and completed this clinical trial. The results showed that the FF intervention for 7 days decreased platelet aggregation by 7.7% in adenosine diphosphate-stimulated platelets, which was similar to the effect of ASA, which decreased platelet aggregation by 9.4%. FF reduced platelet aggregation by 10.2% in collagen-stimulated platelets, and ASA reduced platelet aggregation by 38.3% in collagen-activated platelets. This suggests that ASA exerts a stronger inhibitory effect than FF on collagen-stimulated platelet aggregation. The combination of FF + ASA did not exert a synergistic inhibitory effect on platelet aggregation. Treatment with FF significantly decreased plasma TXB2, 6-keto-PGF1α, and PF4 levels, and its effects were similar to ASA. Conclusion: Fruitflow® suppressed platelet aggregation and decreased TXB2, 6-keto-PGF1α, and PF4 levels in elderly participants. These findings indicate that FF might reduce the risk of thrombosis in cardiovascular diseases.Trial registration code: ChiCTR2000034647 at www.clinicaltrials.gov.

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Potential Protective Role of Blood Pressure-Lowering Drugs on the Balance between Hemostasis and Fibrinolysis in Hypertensive Patients at Rest and During Exercise

Cited by 6 publications

References 523 publications

Synthetic repurposing of drugs against hypertension: a datamining method based on association rules and a novel discrete algorithm

Synthetic repurposing of drugs against hypertension: a datamining method based on association rules and a novel discrete algorithm

Increased One-Year Recurrent Ischemic Stroke after First-Ever Ischemic Stroke in Males with Benign Prostatic Hyperplasia

Inhibitory effect of Fruitflow on platelet function: a randomized placebo-controlled trial in elderly subjects

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