Potential protective properties of flax lignan secoisolariciresinol diglucoside

Abstract

Lignans are a group of phytonutrients which are widely distributed in the plant kingdom. Flaxseed is the richest source of providing lignan precursor such as secoisolariciresinol diglucoside (SDG). This article reviews the studies relevant to experimental models in animals and humans demonstrating the possible nutraceutical actions of SDG to prevent and alleviate lifestyle-related diseases. A local and international web-based literature review for this project was carried out to provide information relating to the study. The major key word “SDG” was selected to gather information using the electronic databases pertaining to the current state of flaxseed lignans composition, bioactive compounds, metabolism and to find out their role in terms of chemopreventive action. The extraction methods vary from simple to complex depending on separation, fractionation, identification and detection of the analytes. The majority of studies demonstrate that SDG interferes with the development of different types of diseases like cardiovascular, diabetic, lupus nephritis, bone, kidney, menopause, reproduction, mental stress, immunity, atherosclerosis, hemopoietic, liver necrosis and urinary disorders due to its various biological properties including anti-inflammatory, antioxidant, antimutagenic, antimicrobial, antiobesity, antihypolipidemic and neuroprotective effects. Moreover, SDG has a defending mediator against various cancers by modulating multiple cell signaling pathways. As discussed in this review, SDG has shown therapeutic potential against a number of human diseases and can be recommended for discerning consumers.

The Protective Role of Flaxseed Lignan in Male Rabbits With High-Fat Diet: Histopathological Study

“…In addition to that this study coincided with the latest study done by (Mohammed et al, 2015) [22] who reported flaxseed lignan do as a useful therapeutic hepato-nephroprotective agent. Flaxseed supplementation may supply a new therapeutic design in order to decrease hypertriglyceridemia and fatty liver in rats.…”

Binary ethanol–water solvents affect phenolic profile and antioxidant capacity of flaxseed extracts

“…Flax phenolics (e.g. lignans) are particularly in focus because of their antioxidant and oestrogenic activity [4,5]. Currently, the effective isolation of flax phenolic compounds is desirable due to their potential application as a food ingredient [4].…”

Glutathione S-transferases and UDP-glycosyltransferases Are Involved in Response to Aluminum Stress in Flax

“…The alterations in the expression of UGTs under Al exposure were observed in rice (Huang et al, 2009), buckwheat (Yokosho et al, 2014), and maize (Mattiello et al, 2014). In flax, UGTs attract special attention because of their participation in the biosynthesis of lignans—phytoestrogens with antimicrobial, antifungal, antiviral, and antioxidant activity—which have therapeutic effects against human diseases (Dixon, 2004; Pan et al, 2009; Barvkar et al, 2012; Ghose et al, 2014; Imran et al, 2015). UGTs catalyze the glucose conjugation of monolignols that is essential for normal cell wall lignification (Lin et al, 2016).…”