Potential Protective Effect of Zingiber officinale in Comparison to Rosuvastatin on High-fat diet-induced Non-alcoholic Fatty Liver Disease in Rats

Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease affecting nearly 25% of adults worldwide with related risk factors including obesity, metabolic, and inflammatory diseases. Many therapeutic remedies of natural or synthetic properties were used. AIM: This study aimed to investigate and compare the effects of ginger/rosuvastatin (ROSU) on the liver of rats with induced NAFLD. MATERIALS AND METHODS: Forty adult male albino rats were used in this study and divided into four equal subgroups, Group I, control received the standard rat chow diet and given normal saline (1 ml/kg/day), Group II, high-fat diet (HFD) group, Group III, received HFD+ ROSU (15 mg/kg/day), and Group IV, HFD+ Zingiber officinale (10% W/V) for 6 weeks. At the end of our experiment, the rats were sacrificed then blood samples were collected for biochemical analysis of lipid profiles and liver enzymes, liver specimen was prepared for light and electron microscopic examination, and measurement of tissue level of malondialdehyde. RESULTS: NAFLD caused degenerative changes and lipid deposition in liver cells as evidenced by microscopic results and laboratory tests. Treatment with ginger/ROSU alleviated those changes. CONCLUSION: Ginger and ROSU could ameliorate liver functions in NAFLD and ginger effect is superior to ROSU.

Methanol Leaves Extract of Zingiber officinale (Roscoe) exhibited Anti-Obesity Effect in Wistar Rats Fed with a High Fat Diet

“…In this study, methanol leaves extract of Z. officinale demonstrated an anti-dyslipidemic effect by restoring the lipid profile, lowering AI and CRI in the rats. These results support those of Ramadan et al 40 in which Z. officinale rhizomes produced anti-dyslipidaemic effect in HFD induced rats.…”

“…HFD is known to affect liver metabolism, causing steatosis, which is a complicated disorder related to mitochondrial changes and increased formation of reactive oxygen species 44 . This concept explains the significant 40 where Z. officinale rhizomes led to a reduction in oxidative stress of rats fed with HFD.…”

The Combination of Mesenchymal Stem Cells and Bovine Colostrum in Reducing α-SMA Expression and NLR Levels in Wistar Rats After 50% Fibrotic Liver Resection

“…The process of hepatic fibrogenesis triggers myofibroblasts to become active which then results in the expression of α-smooth muscle actin (α-SMA) as a molecular marker that continues to rise, along with the increase of extracellular matrix in the liver [4], [5]. In addition, there is a systemic increase in immune system cells, such as neutrophils and lymphocytes ratio (NLR), along with fat accumulation in liver is also one of the key contributors of liver fibrosis [6], [7], [8]. In light of the above findings, the fibrosis process will persist, resulting in reduced liver function.…”