Potential protective effect of Trans-10-hydroxy-2-decenoic acid on the inflammation induced by Lipoteichoic acid

Chen, Yifan; You, Mengmeng; Liu, Yichen; Shi, Yizhen; Wang, Kai; Lu, Yuanyuan

doi:10.1016/j.jff.2018.03.029

Cited by 24 publications

(21 citation statements)

References 44 publications

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“…The mRNA expression of circadian genes in the livers and hypothalamus suprachiasmatic nucleus (SCN) were measured by qRT‐PCR according to a previous study (Chen et al, ; You et al, ). In brief, RNA was extracted using RNA extraction kits (Cat No: RN03, Aidlab Biotechnologies Co. Ltd., Beijing, China).…”

Section: Methodsmentioning

confidence: 99%

Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats

et al. 2020

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Nonalcoholic fatty liver disease (NAFLD) has a high incidence in postmenopausal women and is accompanied by insulin resistance, obesity, and dyslipidemia. Royal jelly (RJ), a natural substance derived from hive, possesses numerous health‐beneficial properties. Here, we evaluated the effects of RJ (150, 300, and 450 mg kg–1 day–1, 8 weeks) on NAFLD in ovariectomized (OVX) rats. Based on the results, RJ ameliorated the degree of anxiety, improved serum lipid profile, and attenuated the hepatic steatosis and liver injury in OVX rats. Furthermore, the protective effects of RJ could be attributed to its antioxidant properties, which enhance the levels of hepatic antioxidant enzymes. The qRT‐PCR results also suggest that RJ improves the disturbances of circadian genes by downregulating their expression, including that of Per1 and Per 2, in the liver of OVX rats. Altogether, our findings suggest that RJ may be a promising agent for the treatment of NAFLD. Practical applications Postmenopausal women are at an increased risk of NAFLD. Currently, there are no licensed therapies for NAFLD. Although hormone replacement therapy (HRT) is reported to inhibit the development of NAFLD, it causes unexpected adverse effects. As HRT is controversial, the use of natural supplements to counteract the detrimental effects of menopause has recently attracted more attention. RJ is a natural product secreted from the hypopharyngeal and mandibular glands of worker bees. The present study illustrates the protective effect of the natural product, RJ, and its underlying mechanisms on NAFLD. This is the first study to assess the effect of RJ on NAFLD under estrogen deficiency. Such findings contribute to the further utilization of RJ, which might serve as a promising therapeutic option and natural food for the treatment of NAFLD.

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Section: Methodsmentioning

confidence: 99%

Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats

et al. 2020

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“…Previous studies [ 5 , 6 ] have demonstrated that 10-HDA reduced inflammatory reaction by decreasing the production of upstream IFN-β or TNF-α, inhibiting the start of nuclear factor-kappa B (NF-κB) pathways and decreasing the production of downstream IL-6. Chen et al (2018) [ 20 ] reported that oral administration of 0.1 g/kg BW 10-HDA per day for one week lessened the level of IL-10, IL-6, and TNF-α in serum of mice. Intragastrical administration with 0.1 g/kg BW 10-HDA per day for one week promoted the growth of immune organs, as well as revived the multiplication and function of T cell and B cell in the thymus and spleen [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

10-Hydroxy-trans-2-decenoic Acid, a New Potential Feed Additive for Broiler Chickens to Improve Growth Performance

Zhang

Geng

et al. 2022

Animals

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The purposes of this study were to explore the potential possibility of 10-hydroxy-trans-2-decenoic acid (10-HDA) use in feeding broiler chickens. A total of 216 healthy 1-day-old chicks were divided into 2 treatments at random (diets supplemented with 0 or 40 mg/kg 10-HDA, respectively) with 6 replicates of 18 birds each, and were then reared for 42 days. The results found that a diet supplemented with 10-HDA significantly increased average daily gain of broiler chickens in d 22~42 and d 0~42. Compared with the control group, dietary inclusion of 10-HDA markedly increased the serum concentrations of immunoglobulin (Ig) G at d 21, as well as IgM and interleukin (IL)-10 at d 42, while decreasing the levels of tumor necrosis factor (TNF)-α at d 21, as well as IL-6, TNF-α, and IL-1β at d 42. Furthermore, broiler chickens fed a diet with 10-HDA had a higher (p < 0.05) serum activity of superoxide dismutase at d 42. Additionally, serum malondialdehyde content also decreased notably at d 21 and d 42. These results made it clear that 10-HDA increased the growth performance of broiler chickens, possibly by enhancing immune function and antioxidant capacity.

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“…It therefore, protects bee larvae against virulent bacterial infections that affect bee hives such as those caused by some strains of Paenibacillus larvae [27]. In mammals, it protects mice against pulmonary damage induced by lipoteichoic acid, a toxin from Staphylococcus aureus [28]. It also exerts an antibacterial effect against various pathogenic bacterial species in human cancer colon cells [29].…”

Section: Chemical Composition Of Rjmentioning

confidence: 99%

Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans

Kunugi

Ali

2019

IJMS

143

154

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Aging is a natural phenomenon that occurs in all living organisms. In humans, aging is associated with lowered overall functioning and increased mortality out of the risk for various age-related diseases. Hence, researchers are pushed to find effective natural interventions that can promote healthy aging and extend lifespan. Royal jelly (RJ) is a natural product that is fed to bee queens throughout their entire life. Thanks to RJ, bee queens enjoy an excellent reproductive function and lengthened lifespan compared with bee workers, despite the fact that they have the same genome. This review aimed to investigate the effect of RJ and/or its components on lifespan/healthspan in various species by evaluating the most relevant studies. Moreover, we briefly discussed the positive effects of RJ on health maintenance and age-related disorders in humans. Whenever possible, we explored the metabolic, molecular, and cellular mechanisms through which RJ can modulate age-related mechanisms to extend lifespan. RJ and its ingredients—proteins and their derivatives e.g., royalactin; lipids e.g., 10-hydroxydecenoic acid; and vitamins e.g., pantothenic acid—improved healthspan and extended lifespan in worker honeybees Apis mellifera, Drosophila Melanogaster flies, Gryllus bimaculatus crickets, silkworms, Caenorhabditis elegans nematodes, and mice. The longevity effect was attained via various mechanisms: downregulation of insulin-like growth factors and targeting of rapamycin, upregulation of the epidermal growth factor signaling, dietary restriction, and enhancement of antioxidative capacity. RJ and its protein and lipid ingredients have the potential to extend lifespan in various creatures and prevent senescence of human tissues in cell cultures. These findings pave the way to inventing specific RJ anti-aging drugs. However, much work is needed to understand the effect of RJ interactions with microbiome, diet, activity level, gender, and other genetic variation factors that affect healthspan and longevity.

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Potential protective effect of Trans-10-hydroxy-2-decenoic acid on the inflammation induced by Lipoteichoic acid

Cited by 24 publications

References 44 publications

Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats

Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting oxidative stress and regulating the expression of circadian genes in ovariectomized rats

10-Hydroxy-trans-2-decenoic Acid, a New Potential Feed Additive for Broiler Chickens to Improve Growth Performance

Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans

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