Potential protective effect of quercetin on the male reproductive system against exposure of Wistar rats to crude oil vapor: Genetic, biochemical, and histopathological evidence

Khazaeel, Kaveh; Daaj, Sameerah Abdul Zahra; Sadeghi, Abbas; Tabandeh, Mohammad Reza; Basir, Zahra

doi:10.1016/j.reprotox.2022.08.001

Cited by 11 publications

(3 citation statements)

References 40 publications

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“…In addition, QUE can prevent the activation of other oxidative stress pathways, including the NF‐kB pathway, as well as signal transduction pathways and ROS caused by environmental factors (Xu et al, 2019). Our recent study showed that the oral administration of QUE can protect the male reproductive system against COV‐induced toxicity by reducing cellular oxidative stress and the expression of apoptotic genes (Khazaeel et al, 2022). The potential role of QUE in the treatment of diseases associated with bone loss has been accompanied by encouraging results.…”

Section: Discussionmentioning

confidence: 99%

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Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor

Hussein,

Khazaeel,

Ranjbar

et al. 2023

Birth Defects Research

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BackgroundEpidemiological evidence indicates a relationship between maternal exposure to crude oil vapors (COV) during pregnancy and adverse pregnancy outcomes. Quercetin (QUE) is a plant flavonoid with purported antioxidant and anti‐inflammatory effects, which has been shown to prevent birth defects. This study was aimed to investigate the protective role of QUE on fetal development and congenital skeletal anomalies caused by exposure of pregnant rats to COV.MethodsTwenty‐four pregnant Wistar rats were randomly categorized into four groups of control, COV, COV + QUE, and QUE (50 mg/kg). The inhalation method was used to expose pregnant rats to COV from day 0 to 20 of pregnancy, and QUE was administered orally during this period. On day 20 of gestation, the animals were anesthetized and a laparotomy was performed, and then the weight and crown rump length (CRL) of the fetuses were determined. Skeletal stereomicroscopic evaluations of fetuses were performed using Alcian blue/Alizarin red staining method, and the expression of osteogenesis‐related genes (Runx2 and BMP‐4) was evaluated using qPCR.ResultsThis study showed that prenatal exposure to COV significantly reduced fetal weight and CRL, and expression of Runx2 and BMP‐4 genes. Moreover, COV significantly increased the incidence of congenital skeletal anomalies such as cleft palate, spina bifida and non‐ossification of the fetal bones. However, administration of QUE with exposure to COV improved fetal bone development and reduced congenital skeletal anomalies.ConclusionQUE can ameliorate the teratogenic effects of prenatal exposure to COV by increasing the expression of osteogenesis‐related genes.

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Section: Discussionmentioning

confidence: 99%

“…In order to expose rats to COV by inhalation method, a vivarium (COV chamber) was designed for this study and used as described previously (Khazaeel et al, 2022). Briefly, this COV chamber had a COV inlet, an outlet valve, and a temperature and humidity regulator for the COV chamber.…”

Section: Methodsmentioning

confidence: 99%

Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor

Hussein,

Khazaeel,

Ranjbar

et al. 2023

Birth Defects Research

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“…Molecular dynamics simulation experiments by Samova et al found that BPA can bind to steroid-binding proteins to reduce their activity, whereas quercetin can compete with BPA, and this seems to be a possible mechanism by which quercetin reduces the testicular toxicity of BPA [89]. In addition to these effects, quercetin has been shown in numerous studies to be protective against testicular damage induced by other environmental pollutants such as crude oil vapor (COV) [90], diesel exhaust particles (DEPs) [91], polychlorinated biphenyls (PCBs) [92], carbon tetrachloride (CCl4) [93], 4-nitrophenol (PNP) [94], 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [95], acetylene [96], and phthalates (PEs) [97,98]. The protective effects of quercetin on exposure to different environmental pollutants are described in Table 1.…”

Section: Other Environmental Pollutants Exposurementioning

confidence: 99%

Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

Zhang

Tang

et al. 2023

Nutrients

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Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies have shown that quercetin mediates multiple beneficial effects in a variety of organ damage and diseases, and is considered a healthcare supplement with health-promoting potential. Male infertility is a major health concern, and testicular damage from multiple causes is an important etiology. Previous studies have shown that quercetin has a protective effect on reproductive function. This may be related to the antioxidant, anti-inflammatory, and anti-apoptotic biological activities of quercetin. Therefore, this paper reviews the mechanisms by which quercetin exerts its pharmacological activity and its role in testicular damage induced by various etiologies. In addition, this paper compiles the application of quercetin in clinical trials, demonstrating its practical effects in regulating blood pressure and inhibiting cellular senescence in human patients. However, more in-depth experimental studies and clinical trials are needed to confirm the true value of quercetin for the prevention and protection against testicular injury.

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Alleviative effect of quercetin against reproductive toxicity induced by chronic exposure to the mixture of phthalates in male rats

Xia,

Liu,

Yue

et al. 2024

Ecotoxicology and Environmental Safety

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Potential protective effect of quercetin on the male reproductive system against exposure of Wistar rats to crude oil vapor: Genetic, biochemical, and histopathological evidence

Cited by 11 publications

References 40 publications

Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor

Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor

Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

Alleviative effect of quercetin against reproductive toxicity induced by chronic exposure to the mixture of phthalates in male rats

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