Potential protective effect of N-acetyl cysteine in acoustic trauma: An experimental study using scanning electron microscopy

Ada, Servet; Hancı, Deniz; Ulusoy, Seçkin; Vejselova, Djanan; Burukoğlu, Dilek; Muluk, Nuray Bayar; Cingi, Cemal

doi:10.17219/acem/64332

Cited by 10 publications

(2 citation statements)

References 23 publications

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“…Additionally, L-NAC's ROS scavenging properties have consistently been shown to ameliorate cochlear damage due to acoustic-trauma at a concentration of 100 mg/kg/day as well as in manganese-induced ROS in rat pups at a concentration of 20 mM. [17,27,28]. In addition to its direct antioxidant effect, L-NAC provides protection for hair cells against TNF-α induced toxicity in OC explants [29].…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma

Eshraghi

Shahal

Davies

et al. 2020

JCM

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Background: Electrode insertion trauma (EIT) during cochlear implantation (CI) can cause loss of residual hearing. L-N-acetylcysteine (L-NAC) and dexamethasone (Dex) have been individually shown to provide otoprotection albeit at higher concentrations that may be associated with adverse effects. Objective/Aims: The aim of this study is to determine whether L-NAC and Dex could be combined to decrease their effective dosage. Materials and Methods: The organ of Corti (OC) explants were divided into various groups: 1) control; 2) EIT; 3) EIT treated with different concentrations of Dex; 4) EIT treated with different concentrations of L-NAC; 5) EIT treated with L-NAC and Dex in combination. Hair cell (HC) density, levels of oxidative stress, proinflammatory cytokines and nitric oxide (NO) was determined. Results: There was a significant loss of HCs in explants subjected to EIT compared to the control group. L-NAC and Dex in combination was able to provide significant otoprotection at lower concentrations compared to individual drugs. Conclusions and Significance: A combination containing L-NAC and Dex is effective in protecting sensory cells at lower protective doses than each compound separately. These compounds can be combined allowing a decrease of potential side effects of each compound and providing significant otoprotection for EIT.

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Section: Discussionmentioning

confidence: 99%

Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma

Eshraghi

Shahal

Davies

et al. 2020

JCM

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“…Oxidative stress is characterized by the presence of DNA damage and lipid peroxidation, generally resulting from the development of free radicals. Noise-induced damage to the cochlea results from degeneration in support cells, afferent nerve fibers, and particularly outer hair cells 2 .…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of berberine on noise-induced hearing loss: a rat model

Kılıç

Sakat

Şahin

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: Noise-induced hearing loss is a preventable form of hearing loss that has serious social and economic impacts. This study aimed to investigate the protective effect of berberine, a potent antioxidant and anti-inflammatory agent, against Noise-induced hearing loss. METHODS: After applying distortion product otoacoustic emission, 28 female Sprague-Dawley rats were randomly divided into four groups. Group 1 was designated as acoustic trauma group, and rats in this group were exposed to white noise for 12 h at an intensity of 4 kHz 110 dB sound pressure level. Group 2 was the control group. Group 3 was designated as the berberine group, and 100 mg/kg of berberine was administered to rats in this group by intragastric lavage for five consecutive days. Group 4 was designated as the acoustic trauma+berberine group. distortion product otoacoustic emission was repeated on the 6 th day of the study and cochlear tissues of rats were dissected for histopathological and immunohistochemical analyses after sacrificing rats. RESULTS: The distortion product otoacoustic emission results showed a significant decrease in signal-noise ratio values at higher frequencies in rats of the trauma group compared to those in other groups. Acoustic trauma caused severe histopathological impairment at cochlear structures together with severe 8-hydroxy-2-deoxyguanosine expression. Rats in the acoustic trauma+berberine group showed mild histopathological changes with mild 8-hydroxy-2-deoxyguanosine expression and better signal-noise ratio values. CONCLUSION: The histopathological and audiological findings of this experimental study showed that berberine provides protection in Noiseinduced hearing loss and may have the potential for use in acoustic trauma-related hearing losses.

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Auditory function and dysfunction: estrogen makes a difference

Delhez

Lefèbvre

Péqueux

et al. 2019

Cell. Mol. Life Sci.

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Potential protective effect of N-acetyl cysteine in acoustic trauma: An experimental study using scanning electron microscopy

Abstract: Background. Oxidative stress has been associated with pathological processes involved in acoustic trauma.

Cited by 10 publications

References 23 publications

Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma

Evaluating the Efficacy of L-N-acetylcysteine and Dexamethasone in Combination to Provide Otoprotection for Electrode Insertion Trauma

The effectiveness of berberine on noise-induced hearing loss: a rat model

Auditory function and dysfunction: estrogen makes a difference

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