Abstract:Zr-based bulk metallic glasses (BMGs) are being studied widely in recent years due to their unique mechanical properties. In this paper, we will present the progress in the studies of corrosion resistance behavior and biomedical potential of the Zr-based BMGs, especially the in vitro and in vivo evaluation of their biocompatibility. Owing to their high resistance to corrosion in a physiological environment and the excellent biocompatibility that give them a passive, stable oxide film, Zr-based BMGs are conside… Show more
“…This includes mainly Be and Ni, however, adverse effects were also observed for Cu [ 65 , 87 , 89 ] and can occur for a sufficient concentration of nearly all important Zr-based metallic glasses components [ 1 ] (e.g., Fe, Co, or Al). Because of their essentiality, getting rid of them is extremely difficult without worsening GFA, mechanical properties, or corrosion resistance [ 38 , 90 , 91 , 92 , 93 , 94 ]. Any deterioration of these functional properties can lead to a worse bio-performance for glassy alloys without the aforementioned elements, which are harmful on their own, than for the ones containing these elements.…”
The continuous development of novel materials for biomedical applications is resulting in an increasingly better prognosis for patients. The application of more advanced materials relates to fewer complications and a desirable higher percentage of successful treatments. New, innovative materials being considered for biomedical applications are metallic alloys with an amorphous internal structure called metallic glasses. They are currently in a dynamic phase of development both in terms of formulating new chemical compositions and testing their properties in terms of intended biocompatibility. This review article intends to synthesize the latest research results in the field of biocompatible metallic glasses to create a more coherent picture of these materials. It summarizes and discusses the most recent findings in the areas of mechanical properties, corrosion resistance, in vitro cellular studies, antibacterial properties, and in vivo animal studies. Results are collected mainly for the most popular metallic glasses manufactured as thin films, coatings, and in bulk form. Considered materials include alloys based on zirconium and titanium, as well as new promising ones based on magnesium, tantalum, and palladium. From the properties of the examined metallic glasses, possible areas of application and further research directions to fill existing gaps are proposed.
“…This includes mainly Be and Ni, however, adverse effects were also observed for Cu [ 65 , 87 , 89 ] and can occur for a sufficient concentration of nearly all important Zr-based metallic glasses components [ 1 ] (e.g., Fe, Co, or Al). Because of their essentiality, getting rid of them is extremely difficult without worsening GFA, mechanical properties, or corrosion resistance [ 38 , 90 , 91 , 92 , 93 , 94 ]. Any deterioration of these functional properties can lead to a worse bio-performance for glassy alloys without the aforementioned elements, which are harmful on their own, than for the ones containing these elements.…”
The continuous development of novel materials for biomedical applications is resulting in an increasingly better prognosis for patients. The application of more advanced materials relates to fewer complications and a desirable higher percentage of successful treatments. New, innovative materials being considered for biomedical applications are metallic alloys with an amorphous internal structure called metallic glasses. They are currently in a dynamic phase of development both in terms of formulating new chemical compositions and testing their properties in terms of intended biocompatibility. This review article intends to synthesize the latest research results in the field of biocompatible metallic glasses to create a more coherent picture of these materials. It summarizes and discusses the most recent findings in the areas of mechanical properties, corrosion resistance, in vitro cellular studies, antibacterial properties, and in vivo animal studies. Results are collected mainly for the most popular metallic glasses manufactured as thin films, coatings, and in bulk form. Considered materials include alloys based on zirconium and titanium, as well as new promising ones based on magnesium, tantalum, and palladium. From the properties of the examined metallic glasses, possible areas of application and further research directions to fill existing gaps are proposed.
“…In regards to MGs, it is the materials overall improved physical, mechanical, and chemical properties that have caught researchers attention. As a frozen liquid, MGs fail to crystallize during solidification, resulting in the absence of crystalline defects such as grain boundaries, dislocations and vacancies Zr‐based MGs are for example recognized by their high strength (1700 MPa) and hardness (590 HV), as well as relatively low elasticity (50–100 GPa for Zr‐based MGs compare to 3–50 GPa for the cortical bone) and corrosion rate in various aqueous environments. However, Zr‐based MGs has been reported to be susceptible to pitting corrosion in aqueous solutions containing halide ions (Cl − and F − ) due to the preferential absorption of Cl − and F − ions to the surfaces of the material .…”
Electrochemical behavior of, and metal ion release from the bulk amorphous (glassy) Zr55Cu30Ni5Al10 alloy (Zr‐MG) was evaluated in simulated body fluid (phosphate buffer saline [PBS]), with and without additions of protein (albumin Fraction V) at pH 7.4 and 5.2 and at body temperature 310 K (37 °C). The passivation behavior and susceptibility to pitting of the Zr‐MG was compared with conventional load bearing implant materials, that is, the medical grade ASTM F75 cast CoCrMo alloy (CoCrMo) and AISI 316 LVM low carbon vacuum re‐melted stainless steel alloy (SS). Furthermore, the metal ion release from the main constituent elements of each alloy was measured and compared. All materials showed passive behavior in the PBS solution with and without presence of albumin, though the passive region was smaller for the Zr‐MG compared to the CoCrMo and SS. Moreover, all materials experienced pitting corrosion in the PBS solution while the Zr‐MG was the most susceptible and the CoCrMo was the least one. Protein additions to the CoCrMo and SS prevented the formation of stable pits at pH 7.4 and 5.2. A decrease in passive region and pitting potential was seen in the case of albumin additions for the Zr‐MG at pH 7.4, while the opposite was seen at pH 5.2. Furthermore, the total metal ion release from the Zr‐MG was less than for the CoCrMo.
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