Potential pathobionts in vaginal microbiota are affected by fish oil and/or probiotics intervention in overweight and obese pregnant women

Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

“…More to the point, a recent RCT assessed the effects of fish oil (1.9 g DHA and 0.22 g EPA) and/or probiotic ( Lacticaseibacillus rhamnosus and Bifidobacterium animalis ssp. lactis) dietary supplements on the vaginal microbiota of women affected by overweight or obesity throughout gestation [ 83 ]. A decreased quantity of possible pathobionts, such as Ureaplasma urealyticum in the fish oil group, Ureaplasma , Ureaplasma urealyticum, and Prevotella disiens in the probiotics group, and Dialister invisus and Peptoniphilus timonensis in the fish oil plus probiotics group, were detected [ 83 ].…”

“…lactis) dietary supplements on the vaginal microbiota of women affected by overweight or obesity throughout gestation [ 83 ]. A decreased quantity of possible pathobionts, such as Ureaplasma urealyticum in the fish oil group, Ureaplasma , Ureaplasma urealyticum, and Prevotella disiens in the probiotics group, and Dialister invisus and Peptoniphilus timonensis in the fish oil plus probiotics group, were detected [ 83 ]. Remarkably, the favorable effect of probiotics supplementation on vaginal microbiome components was enhanced by the decreased quantity of probable pathobionts, like Prevotella , Peptoniphilus , Dialister, and Campylobacter, from the initial months to the final months of gestation [ 83 ].…”

Integrated microbiome, metabolome and transcriptome profiling reveals the beneficial effects of fish oil and Bacillus subtilis jzxj-7 on mouse gut ecosystem

“…Clinical evidence suggests that co-treatment with n-3 PUFAs and probiotics significantly modifies low-grade inflammation during pregnancy but not when n-3 PUFAs and probiotics are given alone. 29,30 n-3 PUFAs are known as the new generation of prebiotics which can be fermented by intestinal microorganisms to produce medium-and short-chain fatty acids, while improving the functional performance of intestinal mucosal barrier and reshaping immune balance. 31 Our studies also show that FO and B. subtilis jzxj-7 administration could not only significantly inhibit the intestinal fibrosis protein expression of TICP and TIIICP to enhance the tight junctions, but also improve the antioxidant activities and thereby alleviate colonic inflammation.…”

Probiotics for preventing gestational diabetes in overweight or obese pregnant women: A review

“…Chronic inflammatory reaction increases IR, deceases insulin-like growth factor binding protein (IGFBP), disrupts the function of pancreatic β cells and insulin secretion, which can cause and promote progression of GDM[ 39 ]. New means to stabilize the microbial balance during pregnancy could benefit maternal health[ 40 ]. Pregnant women may benefit from gut microbiota targeted dietary supplementation[ 37 ].…”