Potential of Zerumbone as an Anti-Cancer Agent

Girisa, Sosmitha; Shabnam, Bano; Monisha, Javadi; Fan, Li; Halim, Clarissa Esmeralda; Arfuso, Frank; Ahn, Kwang Seok; Sethi, Gautam; Kunnumakkara, Ajaikumar B.

doi:10.3390/molecules24040734

Cited by 117 publications

(96 citation statements)

References 155 publications

(195 reference statements)

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“…A number of studies have shown direct anti-cancer effects of zerumbone numerous cancer cell lines derived from the breast, brain, liver, lung and colon (reviewed in [29]). Zerumbone modulated various proteins and signaling pathways including the IL-6/JAK2/STAT3 and NF-κB pathways and the associated pro-carcinogenic genes such as IL-6, COX2 and cyclin D1, thus inhibiting cellular proliferation and promoting apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice

Hwang

Hong

et al. 2020

IJMS

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Chronic inflammation has been linked to colitis-associated colorectal cancer in humans. The human symbiont enterotoxigenic Bacteroides fragilis (ETBF), a pro-carcinogenic bacterium, has the potential to initiate and/or promote colorectal cancer. Antibiotic treatment of ETBF has shown promise in decreasing colonic polyp formation in murine models of colon cancer. However, there are no reported natural products that have shown efficacy in decreasing polyp burden. In this study, we investigated the chemopreventive effects of oral administration of zerumbone in ETBF-colonized mice with azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced tumorigenesis. Zerumbone significantly reduced the severity of disease activity index (DAI) scores as well as several parameters of colonic inflammation (i.e., colon weight, colon length, cecum weight and spleen weight). In addition, inflammation of the colon and cecum as well as hyperplasia was reduced. Zerumbone treatment significantly inhibited colonic polyp numbers and prevented macroadenoma progression. Taken together, these findings suggest that oral treatment with zerumbone inhibited ETBF-promoted colon carcinogenesis in mice indicating that zerumbone could be employed as a promising protective agent against ETBF-mediated colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice

Hwang

Hong

et al. 2020

IJMS

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“…The proapoptotic effect of zerumbone, one of the main constituents of EOs from Zingiber zerumbet and Cheilocostus speciosus [171] was proved in human melanoma CHL-1 cells through induction of ROS, reduction of mitochondrial matrix potential and mitochondrial biogenesis mediated by reduced mitochondrial ATP synthesis, mitochondrial DNA levels, and mRNA expression of mitochondrial transcription factor A level, a mitochondrial biogenesis factor [138]. Activation of apoptosis through downregulation of Bcl-2 and upregulation of Bax and cytochrome c gene and protein levels, as well as activation of caspases 3, was also observed in A375 cells after treatment with zerumbone [139].…”

Section: Induction Of Apoptosismentioning

confidence: 99%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.

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“…Along with various available treatments, the use of natural plant products as medicines provides a new horizon for the treatment of various types of diseases [7][8][9][10][11]. The source of about 60% of the available drugs are natural raw materials from plants [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone raddeana Regel

et al. 2020

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Natural compounds extracted from plants have gained immense importance in the fight against cancer cells due to their lesser toxicity and potential therapeutic effects. Raddeanin A (RA), an oleanane type triterpenoid is a major compound isolated from Anemone raddeana Regel. As an anticancer agent, RA induces apoptosis, cell cycle arrest, inhibits invasion, migration and angiogenesis in malignant cell lines as well as in preclinical models. In this systemic review, the pharmacological effects of RA and its underlying molecular mechanisms were carefully analyzed and potential molecular targets have been highlighted. The apoptotic potential of RA can be mediated through the modulation of Bcl-2, Bax, caspase-3, caspase-8, caspase-9, cytochrome c and poly-ADP ribose polymerase (PARP) cleavage. PI3K/Akt signaling pathway serves as the major molecular target affected by RA. Furthermore, RA can block cell proliferation through inhibition of canonical Wnt/β-catenin signaling pathway in colorectal cancer cells. RA can also alter the activation of NF-κB and STAT3 signaling pathways to suppress invasion and metastasis. RA has also exhibited promising anticancer potential against drug resistant cancer cells and can enhance the anticancer effects of several chemotherapeutic agents. Overall, RA may function as a promising compound in combating cancer, although further in-depth study is required under clinical settings to validate its efficacy in cancer patients.

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Potential of Zerumbone as an Anti-Cancer Agent

Cited by 117 publications

References 155 publications

Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice

Protective Effects of Zerumbone on Colonic Tumorigenesis in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized AOM/DSS BALB/c Mice

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Anticancer Potential of Raddeanin A, a Natural Triterpenoid Isolated from Anemone raddeana Regel

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