Potential of Wild Populations Resources of Arum Maculatum L. (Araceae) in Bulgaria – a Prospective Medicinal Plant

Kozuharova, Ekaterina; Kochmarov, Vladimir; Semerdjieva, Ivanka; Mincheva, Irena; Gibernau, Marc

doi:10.7546/crabs.2018.02.06

Cited by 2 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The genus Arum L., which grows in Europe, Western and Central Asia and North Africa, comprises 29 species and belongs to Araceae family [1,2]. Arum maculatum L., which is also known as cuckoo pint, lords and ladies, devils and angels, cows and bulls, Adam and Eve, adder's root or sneakshead, is a perennial, deciduous woodland plant, which is distributed in Europe, East Ukraine and Anatolia [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…It is reported that the plant is traditionally used against various disorders, such as hemorrhoids, pain, inflammation, sore throat and mumps [3,12,13], and the use of the herbal material as a folk remedy inspired the researchers to reveal the bioactivity of the plant, yielding a number of studies showing different effects of A. maculatum (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Food, medicine or a poisonous plant: Arum maculatum L.

Ergene¹,

KARAASLAN²

2023

jrp

View full text Add to dashboard Cite

Arum maculatum L., which is known with various names such as cuckoo pint and sneakshead, is a perennial, deciduous woodland plant distributed in Europe, East Ukraine and Anatolia. The phytochemical studies revealed that the plant contains different groups of bioactive components, such as alkaloid, saponin, cyanogenic glycosides, terpenic compounds, proanthocyanidins, carotenoids, volatile amines, lectin, mucilage, gum and starch. Various traditional uses are recorded such as antihypertensive, antirheumatic, antihemorrhoidal, analgesic, antidiabetic as well as its use against burns and wounds, Fasciola hepatica, sore throat and cold. It is also consumed as vegetable in different cultures. In the Southeastern region of Turkey, a traditional soup called "tirşik soup" is prepared from the leaves of A. maculatum and used for the treatment of hemorrhoids, respiratory and gastrointestinal disorders and cancer. It is very crucial to apply a specific process for the preparation of the dish or medicinal remedy, since all parts of the fresh plant are known to be toxic. The toxic effect majorly rises from the oxalate crystals found in the content of the plant, along with some other components, such as cyanogenic glycosides, volatile amins, alkaloids etc. Although the bioactivity studies showed antioxidant, antimicrobial, antiinflammatory, analgesic, antiangiogenic and insecticidal activities as well as its protective activity against hemorrhoids; further research is needed on the bioactivity, cytotoxicity and phytochemistry of the plant in order to clarify the mechanisms of action and provide the safe use of the drug.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Food, medicine or a poisonous plant: Arum maculatum L.

Ergene¹,

KARAASLAN²

2023

jrp

View full text Add to dashboard Cite

show abstract

“…Among the diverse medicinal plants with documented ethnopharmacological use as remedies for hemorrhoidal disease, special attention is focused on Arum maculatum, and related species from this genus, by virtue of their well-known application in the traditional medicine of the Balkans, Asia Minor and the Middle East [18][19][20]. The rationale for the medicinal use of this herb has been recently validated in a randomized clinical trial documenting significant improvement in health-related quality of life outcomes in patients with hemorrhoidal disease [21].…”

Section: Introductionmentioning

confidence: 99%

“…In continuation of our preceding botanical, autecological and ethnopharmacological exploration of Arum maculatum [18,20,22], we herein report a pharmacological evaluation of two hydro-alcoholic extracts of the plant using several pharmacological endpoints, namely modulation of collagenase and cyclooxigenase activities, effects on human vascular endothelial proliferation and viability and antioxidant and antiradical activities, to characterize its mode of action as a remedy for hemorrhoidal disease.…”

Section: Introductionmentioning

confidence: 99%

Exploration of collagenase, cyclooxigenases, angiogenesis and free radical processes as the putative pharmacological targets of Arum maculatum L.

Kochmarov

Marinov

Kozuharova

et al. 2020

Biotechnology & Biotechnological Equipment

Self Cite

View full text Add to dashboard Cite

In line with the well-established ethnobotanical use of Arum maculatum for the treatment of hemorrhoidal disease, we sought to determine the activities of 30% or 70% ethanol extracts of the plant tubers in an array of pharmacological and biochemical models of some crucial events implicated in the pathogenesis of this disorder, namely angiogenesis, collagenase activity remodeling, cyclooxygenase activity, IL-2 secretion and oxidative stress. The tested hydro-alcoholic extracts from A. maculatum tubers inhibited the proliferation of EA.hy926 vascular endothelial cells, but even at the highest administered concentrations no decrease in viability was observed. The extracts induced a concentration-dependent decrease in collagenase activity, whereby the effects were more pronounced at the lower concentration of ethanol in the extragent. Moreover the tested extracts induced concentration-dependent suppression of cyclooxygenase activity (COX-1 and 2), albeit at very high and presumably supraphysiological concentrations. The extracts augmented the PHA/PMA-induced secretion of IL-2 from Jurkat E.6 (human T-cells), which was more pronounced following exposure to the 30% ethanol-derived product. The 30% EtOH extract demonstrated anti-radical properties against both stable free radicals (ABTS and DPPH) and biologically relevant reactive oxygen species (ROS), which could be considered as important mediators of inflammation and signaling molecules. Our findings give us reason to conclude that the hydroalcoholic extracts of A. maculatum tubers possess anti-inflammatory, antiangiogenic and antioxidant effects which in concert could contribute to its efficacy for the management of hemorrhoidal disease.

show abstract

Potential of Wild Populations Resources of Arum Maculatum L. (Araceae) in Bulgaria – a Prospective Medicinal Plant

Cited by 2 publications

References 0 publications

Food, medicine or a poisonous plant: Arum maculatum L.

Food, medicine or a poisonous plant: Arum maculatum L.

Exploration of collagenase, cyclooxigenases, angiogenesis and free radical processes as the putative pharmacological targets of Arum maculatum L.

Contact Info

Product

Resources

About