Potential of ultrasound diagnosis for parotid tumors: Analysis of qualitative and quantitative parameters

Bozzato, Alessandro; Zenk, Johannes; Greeß, H.; Hornung, Joachim; Gottwald, Frank; Rabe, Christina; Iro, Heinrich

doi:10.1016/j.otohns.2007.05.062

Cited by 71 publications

(62 citation statements)

References 16 publications

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“…The results were statistically insignificant (P = 0.06). 2 Iran J Radiol. In Press(In Press):e64039.…”

Section: 91)mentioning

confidence: 99%

“…Of note, preoperative differentiation between malignant and benign salivary tumors is essential for surgical planning (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Despite the high sensitivity of these radiological techniques, the accuracy of predicting histopathology of salivary gland masses is lower than expected as morphologic characteristics of benign and malignant lesions may overlap frequently (1)(2)(3)(4)(5)(6)(7). In addition, they have several limitations in daily practice.…”

Section: Introductionmentioning

confidence: 99%

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Sonoelastographic Features of Major Salivary Gland Tumors and Pathology Correlation

Farasat¹,

Ovalı

Düzgün

et al. 2017

Iran J Radiol

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Objectives: To investigate the diagnostic efficiency of elastography in differentiation of malignant and benign tumors by evaluating salivary gland masses in means of their elastography scores and strain ratios. Patients and Methods: Twenty five patients with salivary gland mass lesions were detected through B-mode ultrasonography, Doppler ultrasonography, strain elastography and their strain ratios were calculated. The results were compared with histopathologic results. Results: Twenty five patients had 27 lesions consisting of seven malignant and 20 benign lesions. Mann Whitney U test, ROC analysis, Fisher test and Chi square tests were used statistically. Mean strain rates were calculated as 2.26 ± 0.29 in the benign group and 2.02 ± 0.59 in the malignant group. There was no statistically significant difference between the two groups (P = 0.698). Elastography score was calculated as mean 2.4 ± 0.94 in the benign group and mean 2.28 ± 0.38 in the malignant group. There was no statistically significant difference between the two groups (P = 0.708). Accepting the strain rate as 0.89; sensitivity of elastography in differentiating malignant from benign lesions is 71%, and the specificity is 50%. However, the area under the ROC curve is 0.55, which is not statistically significant (P = 0.699). Conclusion: Elastography is a supporting method for B-mode ultrasonography in the differentiation of benign and malignant salivary gland masses. However, the overlap of elastographic findings is evident in benign and malignant masses. Care should be taken to have tissues with similar stiffness under the reference tissue and the lesions in elastographic evaluation of the superficial mass. We have not met a study that has pointed out the importance of stiffness of the tissue located beneath the lesion that may affect the elastography results in the literature. In this respect our study is unique.

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“…The results were statistically insignificant (P = 0.06). 2 Iran J Radiol. In Press(In Press):e64039.…”

Section: 91)mentioning

confidence: 99%

“…Of note, preoperative differentiation between malignant and benign salivary tumors is essential for surgical planning (1,2).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sonoelastographic Features of Major Salivary Gland Tumors and Pathology Correlation

Farasat¹,

Ovalı

Düzgün

et al. 2017

Iran J Radiol

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“…Ultrasound plays an important role in the diagnosis of space-occupying lesions. Some studies [1][2][3][4] found that ultrasound was able to differentiate between benign and malignant parotid masses with high accuracy while other studies [5][6][7][8][9] presented opposing conclusions. The aim of this study was to assess the role of ultrasound in the evaluation of benignity and malignancy of parotid gland masses.…”

Section: Introductionmentioning

confidence: 99%

Role of ultrasound in the assessment of benignity and malignancy of parotid masses

Wu¹,

Liu²,

Chen³

et al. 2012

Dentomaxillofacial Radiology

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Objectives: This study aimed to investigate the value of ultrasound in the identification of benign and malignant parotid masses. Methods: Data of 189 patients with parotid gland masses undergoing ultrasound-guided fineneedle aspiration (FNA), core biopsy or surgery were reviewed retrospectively and the presumed sonographic diagnoses were compared with the histopathology. The sensitivity, specificity and accuracy of sonographic diagnoses were assessed and the sonographic characteristics of those lesions, including shape, margin, echogenicity, echotexture and vascularization, were studied. Results: Of the 189 patients, the final pathological diagnosis included 18 malignant tumours and 171 benign masses; the presumed sonographic diagnoses showed 165 cases as benign and probably benign masses (11 cases were confirmed malignant, 154 cases benign) and 24 cases were diagnosed as probably malignant and malignant masses (7 cases were confirmed malignant, 17 cases benign). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of ultrasound for the diagnosis of parotid gland masses were 38.9%, 90.1%, 29.2%, 93.3% and 85.2%, respectively, and accuracy for malignant masses was 20%. The sonographic characteristics of parotid masses between benign and malignant lesions had no significant differences. The parotid gland masses in this study included pleomorphic adenoma, Warthin's tumour, retention cyst, haemangiomas, chronic granuloma, lymphoma, fibrolipoma, abscess, basal cell adenoma, oncocytoma, lymphatic tuberculosis, myoepithelioma, neurilemmoma, mucoepidermoid carcinoma, adenoid cystic carcinoma, alveolar soft part sarcoma and retinal blastoma (metastasis). Conclusions: It is challenging to use sonography for differentiating between benign and malignant parotid gland masses. To make a definite diagnosis, ultrasound-guided FNA or core biopsy is advocated.

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“…However, these conventional imaging approaches are less precise owing to the overlap in the appearance of parotid tumours. [11][12][13][14] Diffusion-weighted imaging is a technique that could obtain the spatial diffusion map of free-water protons for evaluating molecular diffusivity under motion restriction within the tissues and could be measured with the apparent diffusion coefficient (ADC). 15 Diffusion tensor imaging (DTI) is an extension of diffusionweighted imaging and could measure the incoherent directional distribution of diffusivity with fractional anisotropy (FA).…”

Section: Introductionmentioning

confidence: 99%

Application of DTI and ARFI imaging in differential diagnosis of parotid tumours

Yu¹,

Du²,

Lu³

et al. 2016

Dentomaxillofacial Radiology

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Objectives: To explore the utility of diffusion tensor imaging (DTI) and acoustic radiation force impulse (ARFI) imaging in the diagnosis of parotid tumours. Methods: 51 patients with parotid tumours were examined with DTI on 3.0-T MRI and ARFI imaging on an ultrasound scanner before surgery. Values of apparent diffusion coefficient (ADC), fractional anisotropy (FA) and shear-wave velocity (SWV) were calculated and analyzed with independent samples Wilcoxon-Mann-Whitney test. Cut-off values, sensitivity and specificity were calculated with receiver-operating characteristic (ROC) curve analysis. The value of combination was calculated through parallel test for the cut-off value of ADC, FA and SWV (combination 5 0 or 1); then, ROC analysis was performed with pathological results as the gold standard to calculate the sensitivity and specificity for the combination of the three parameters distinguishing benign and malignant parotid tumours. Pathological diagnosis for every patient was made post-operatively from the tumour tissue taken during operation. Results: There was a significant difference between benign and malignant tumours in the values of ADC, FA and SWV (p 5 0.032, p 5 0.011 and p , 0.0001); a significant difference in the values was also found between pleomorphic adenoma and malignant tumour (p 5 0.0012, p , 0.0001 and p 5 0.0002). The diagnosis cut-off points between benign and malignant tumours for ADC, FA and SWV were 1.02 3 10 23 mm 2 s 21 , 0.24 and 2.76 m s 21 , respectively; the sensitivity for ADC, FA and SWV was 87.50, 62.50 and 68.75%; the specificity was 45.71, 82.86 and 97.14%. Analysis of the combination of the three parameters increased the sensitivity, specificity, Youden index and area under the ROC curve compared with analysis of each parameter alone for distinguishing benign and malignant tumours.

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Potential of ultrasound diagnosis for parotid tumors: Analysis of qualitative and quantitative parameters

Abstract: Although contrast medium analysis provided statistical criteria, these, however, do not possess the ability to improve the diagnostic prediction of tumor histology. Neither the morphologic classification nor contrast medium analysis was able to identify a malignant lesion sufficiently.

Cited by 71 publications

References 16 publications

Sonoelastographic Features of Major Salivary Gland Tumors and Pathology Correlation

Sonoelastographic Features of Major Salivary Gland Tumors and Pathology Correlation

Role of ultrasound in the assessment of benignity and malignancy of parotid masses

Application of DTI and ARFI imaging in differential diagnosis of parotid tumours

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