Potential of tragacanth gum in the industries: a short journey from past to the future

Mallakpour, Shadpour; Tabesh, Farbod; Hussain, Chaudhery Mustansar

doi:10.1007/s00289-022-04284-1

Cited by 7 publications

(4 citation statements)

References 88 publications

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“…Unlike Arabic gum, tragacanth gum forms highly viscous solutions and is considered the most viscous of natural plant gums ( 42 ). While there are no claims regarding the cholesterol-lowering activity of tragacanth gum in the literature, it is outlined its high viscosity and potential in green chemistry ( 38 ), biomedical engineering ( 41 ), and as a prebiotic in functional foods ( 39 ). The high viscosity of the aqueous solutions could explain the experimental difficulties we encountered in obtaining an acceptable ITC thermogram.…”

Section: Resultsmentioning

confidence: 99%

“…Tragacanth gum, an ancient polysaccharide known since the time of Theophrastus, shares some similarities with Arabic gum. It is a natural exudate obtained from the stem of the bush-like plant of the Astragalus species and finds applications in the food and pharmaceutical industries (38)(39)(40)(41)(42). Unlike Arabic gum, tragacanth gum forms highly viscous solutions and is considered the most viscous of natural plant gums (42).…”

Section: Bile Salts Interaction With Tragacanth Gummentioning

confidence: 99%

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ITC study on the interaction of some bile salts with tragacanth, Arabic, and guar gums with potential cholesterol-lowering ability

Massa,

Compari,

Fisicaro

2023

Front. Nutr.

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IntroductionThe urge of designing new safe and natural functional foods to control blood lipids and dispensable without the need of physician supervision, has increased especially after the coming into effect of the recent EU Commission regulation 2022/860, that regulates the consumption of “red yeast rice,” made by fermentation of rice with Monascus purpureus, and perceived as a natural functional food, due to a health risk for frail consumers. The results of the present work are a part of the systematic study we are carrying out of the binding ability of some soluble dietary fibers (SDF) from different natural sources toward selected bile salts (BS).MethodsMeasurements were carried out by isothermal titration calorimetry (ITC) with the idea to shed light on the mechanism, if any, by which they show cholesterol-lowering activity.Results and discussionEpidemiological studies are sometimes conflicting and offer only hypothesis about the mechanism of action, the most accredited being the reduction of reabsorption of BS in the gut. Previous measurements done on negatively charged pectin and alginate, showed specific binding interaction with monomer NaDC for pectin and no interaction at all for alginate. Chitosan, positively charged and soluble only at low pH, in 100 mM acetate buffer at pH = 3 shows strong exothermic interactions with NaTC and NaTDC. Here we considered two plant exudates (Arabic gum and tragacanth gum) and guar gum, extracted from guar beans, and their interaction with the same bile salts. ITC measurements do not evidence specific interactions between gums and the studied BS, so that their cholesterol lowering ability, if any, is due to a different mechanism very probably bound to the viscosity increase. Moreover, the addition of NaC, the most abundant BS in the bile, at very low concentration (under the cmc) causes a structural change of the solution. The obtained results seem to corroborate the hypothesis that the cholesterol lowering activity is related to the increase in viscosity of guar solution favored by NaC, the major component of the bile.

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Section: Resultsmentioning

confidence: 99%

Section: Bile Salts Interaction With Tragacanth Gummentioning

confidence: 99%

ITC study on the interaction of some bile salts with tragacanth, Arabic, and guar gums with potential cholesterol-lowering ability

Massa,

Compari,

Fisicaro

2023

Front. Nutr.

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“…However, the proportions of the particular components, as well as physicochemical properties of the final product, may be different [ 146 ]. The main polysaccharide components are water-insoluble bassorin (60–70%) and water-soluble tragacanthin (30–40%) [ 147 ]. The first one swells and forms a gel upon contact with the other, while the other one dissolves and forms a colloidal sol.…”

Section: Gum-based Micro- and Nanoparticles In Drug Deliverymentioning

confidence: 99%

Natural Gums in Drug-Loaded Micro- and Nanogels

et al. 2023

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Gums are polysaccharide compounds obtained from natural sources, such as plants, algae and bacteria. Because of their excellent biocompatibility and biodegradability, as well as their ability to swell and their sensitivity to degradation by the colon microbiome, they are regarded as interesting potential drug carriers. In order to obtain properties differing from the original compounds, blends with other polymers and chemical modifications are usually applied. Gums and gum-derived compounds can be applied in the form of macroscopic hydrogels or can be formulated into particulate systems that can deliver the drugs via different administration routes. In this review, we present and summarize the most recent studies regarding micro- and nanoparticles obtained with the use of gums extensively investigated in pharmaceutical technology, their derivatives and blends with other polymers. This review focuses on the most important aspects of micro- and nanoparticulate systems formulation and their application as drug carriers, as well as the challenges related to these formulations.

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“…It is due to their characteristics, which include renewability, biocompatibility, biodegradability, stability at a wide pH range, nontoxicity, cost effectiveness, abundance, etc. Following a thorough analysis of numerous articles, it was determined that Tragacanth gum would be an appropriate alternative for petroleum-based components, resulting in a reduction in the price of oil refineries and associated operations (Mallakpour et al, 2022). Tragacanth gum can be utilised as the wall material in the encapsulation of various chemicals, particularly plant extracts, as it is a biocompatible and biodegradable polymer with good qualities like emulsifying, viscosity, and crosslinking ability.…”

Section: Introductionmentioning

confidence: 99%

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

Abdi,

Jain,

Patil

et al. 2024

Front. Mater.

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Natural polymers have many uses, and Tragacanth gum is just one of them. Many people are interested in natural gums because of their many attractive characteristics, such as being ‘green’ bio-based renewable materials, being easily accessible, inexpensive, and structurally diverse. One class of naturally occurring polysaccharides is called gum because of its tendency to create a gel or a thick solution. Among the many plant-based raw materials, these polysaccharide gums are abundant. Hydrogels, which are three-dimensional polymeric webs that can imitate live tissues, have demonstrated remarkable potential as adjustable biomaterials in numerous regenerative techniques due to their high water or biological exudate absorption capacities. Natural polysaccharides, often known as gums, are present in many different types of trees and possess many desirable properties, such as being renewable, biocompatible, biodegradable, non-toxic, and amenable to chemical modification. Many people are curious about certain parts of the food, water, energy, biotech, environmental, and healthcare sectors as of now. Gum, a type of very important and unique food ingredient, has many vital uses in the food business. Cosmetics, coating, photosensitive resin, fertilizer, casting, pharmaceuticals, and tobacco are just a few of the non-food businesses that make use of their strong water-affinity and structural plasticity. There are a lot of benefits to hydrogels made from natural gums as opposed to those made from synthetic sources. Synthesis hydrogel polymers have been the center of interest among these non-food applications because of their extensive use in the pharmaceutical and medical fields. The Tragacanth gum hydrogels used for medication delivery and tissue engineering have been the focus of this study. We also paid close attention to drug delivery, physical-chemical properties, and the extraction of Tragacanth gum. Our research has a wide range of biomedical applications, including tissue engineering for bone, skin, fixation of bone, periodontal, and cartilage. Possible futures based on hydrogels made of Tragacanth gum were likewise our primary focus.

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Potential of tragacanth gum in the industries: a short journey from past to the future

Cited by 7 publications

References 88 publications

ITC study on the interaction of some bile salts with tragacanth, Arabic, and guar gums with potential cholesterol-lowering ability

ITC study on the interaction of some bile salts with tragacanth, Arabic, and guar gums with potential cholesterol-lowering ability

Natural Gums in Drug-Loaded Micro- and Nanogels

Tragacanth gum-based hydrogels for drug delivery and tissue engineering applications

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