Potential of the Phytomedicine Echinacea in the Treatment of Pulmonary Infections and Bronchitis

Hudson, James B.

doi:10.5772/18316

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…Candida albicans was previously reported as sensitive to Echinacea by Merali et al (2003). No common mechanism of antibacterial activity was found, since Echinacea is part of the Asteraceae family, which is known to contain many plants rich in antibacterial polyenes and thiophenes; such compounds might also have contributed to the activities observed (Hudson 2010). Our results confirmed the inhibitory effect of different Echinecea extracts used in this study with results of most studies.…”

Section: Discussionsupporting

confidence: 89%

Active compounds and biological activity of in vitro cultures of some Echinacea purpurea varieties

2018

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Background: Plant cell cultures have developed rapidly in recent years for the synthesis of selected natural products. This study was conducted to evaluate the effect of yeast extract, jasmonic acid, phenylalanine, and tyrosine on total caffeic acid and polysaccharide production in callus cultures of two Echinacea varieties, namely Double Decker and Rubinstern. The biological activities (antioxidant, antimicrobial and cytotoxic activities) of different Echinacea extracts were also evaluated. Results: Data revealed the effect of yeast extract on calli of the two varieties. Double Decker calli recorded maximum caffeic acid derivatives and total hydrolysable sugars after 30 days of cultivation using 1.5 g/l and 1.0 g/l yeast extract respectively whereas, in Rubinstern calli, the maximum caffeic acid derivatives and total hydrolysable sugars were recorded at 1.0 g/l after 30 days. Using 50 mM jasmonic acid, Double Decker calli recorded maximum values of caffeic acid derivatives and total hydrolysable sugars after 15 days. In Rubinstern calli, caffeic acid derivatives and total hydrolysable sugar recorded maximum values after 30 days at 200 mM jasmonic acid and after 15 days at 50 mM jasmonic acid, respectively. In Double Decker variety, caffeic acid derivatives and total hydrolysable sugars recorded maximum values at 100 mg/l phenylalanine. Rubinstern calli recorded maximum value of caffeic acid derivatives at 100 mg/l phenylalanine and total hydrolysable sugars at 50 mg/l phenylalanine. As for tyrosine, maximum values of caffeic acid derivatives and total hydrolysable sugars recorded at 150 mg/l with Double Decker calli. Rubinstern calli recorded maximum value of caffeic acid derivatives and total hydrolysable sugars at 150 and 50 mg/l tyrosine, respectively. The biological activities of the different Echinacea extracts showed that maximum antioxidant activity (89.2%) was recorded with Rubinstern calli. Also, the maximum value of cell death (78.2%) was observed with the extract of Rubinstern calli. For antibacterial activity, most extracts showed inhibitory effect against Bacillus subtilis and Staphylococcus aureus growth. Conclusion: Both elicitors (yeast extract and jasmonic acid) and precursors (phenylalanine and tyrosine) have a clear effect on natural products of the two Echinacea varieties. The investigated Echinacea extracts (in vitro and in vivo plants and calli of the two varieties) showed moderate activity against tested microbial strains.

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Section: Discussionsupporting

confidence: 89%

Active compounds and biological activity of in vitro cultures of some Echinacea purpurea varieties

2018

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“…Rhinoviruses stimulated the secretion of many different cytokines [46,47], including the proinflammatory IL-1, IL-6, IL-8, and TNFα, which are known to be collectively involved in many of the symptoms common to respiratory infections, such as sneezing, fever, sore throat, nasal discharges, and inflammation in various respiratory tissues. Several EP preparations were able to completely or partly reverse this stimulation [48][49][50]. EP could be added before or after virus infection, with similar success, and also the results were not affected by virus dose or the time of exposure to EP [49].…”

Section: Effects Of Ep On Virus-infected Cells: Involvement Of Cytokimentioning

confidence: 75%

“…Several EP preparations were able to completely or partly reverse this stimulation [48][49][50]. EP could be added before or after virus infection, with similar success, and also the results were not affected by virus dose or the time of exposure to EP [49]. It is noteworthy that RV14 and RV1A, which are known to use distinct cellular receptors (ICAM-1 and LDL, resp.…”

Section: Effects Of Ep On Virus-infected Cells: Involvement Of Cytokimentioning

confidence: 78%

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Applications of the PhytomedicineEchinacea purpurea(Purple Coneflower) in Infectious Diseases

Hudson

2012

Journal of Biomedicine and Biotechnology

118

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Extracts of Echinacea purpurea (EP, purple coneflower) have been used traditionally in North America for the treatment of various types of infections and wounds, and they have become very popular herbal medicines globally. Recent studies have revealed that certain standardized preparations contain potent and selective antiviral and antimicrobial activities. In addition, they display multiple immune-modulatory activities, comprising stimulation of certain immune functions such as phagocytic activity of macrophages and suppression of the proinflammatory responses of epithelial cells to viruses and bacteria, which are manifested as alterations in secretion of various cytokines and chemokines. These immune modulations result from upregulation or downregulation of the relevant genes and their transcription factors. All these bioactivities can be demonstrated at noncytotoxic concentrations of extract and appear to be due to multiple components rather than the individual chemical compounds that characterize Echinacea extracts. Potential applications of the bioactive extracts may go beyond their traditional uses.

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“…Popularmente, a E. purpurea se destaca por seu uso no tratamento de feridas, de queimaduras, de infecções de garganta, de dores de dente e, principalmente, em casos de infecções respiratórias e urinárias. A sua utilização pode ser realizada tanto com a mastigação da raiz, quanto através da preparação de chás de diferentes partes da planta, destacandose a aplicação das flores (HUDSON, 2010).…”

Section: Uso Popular E Aplicações Farmacológicasunclassified

Uma Revisão Sobre o Potencial Farmacológico da Echinacea purpurea (L.) Moench Frente às Infeções Respiratórias

Barbosa

Lima²,

Neto

et al. 2022

Ensaios Ciênc.

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Desde os seus primórdios, a humanidade possui o hábito de utilizar plantas medicinais como forma de tratamento em enfermidades, especialmente, perante aquelas que acometem o sistema respiratório, como infecções bacterianas, virais e fúngicas. Por apresentar diversas propriedades farmacológicas, uma das espécies mais utilizadas nestas situações é a Echinacea purpurea. Desse modo, o objetivo do presente estudo foi revisar a literatura disponível sobre o potencial farmacológico da espécie de Echinacea purpurea e o seu uso frente às infecções respiratórias. O estudo foi do tipo exploratório de caráter qualitativo, com uma revisão de literatura. As pesquisas foram realizadas entre 30 de abril a 31 de julho do ano de 2020. Foram utilizadas como palavras-chave de busca “Echinacea purpurea”, “Constituição da E. purpurea”, “Sistema respiratório” e “Infecções respiratórias”. As buscas foram realizadas sendo utilizadas bases de dados, como: PubMed, SciELO e Google Scholar, nos idiomas português, inglês e espanhol. O estudo demonstrou que a Echinacea purpurea é uma planta bastante utilizada popularmente no tratamento de diversas enfermidades, principalmente, em casos de infecções respiratórias. Esta possui um grande potencial biológico por deter fitoconstituintes que apresentam atividades antibacterianas, antivirais, antifúngicas e imunomoduladoras. Entretanto, ainda se faz necessária a realização de pesquisas mais detalhadas acerca da mesma, visto que não são conhecidos todos os seus constituintes, as doses em que esta se prova eficaz em humanos e o seu mecanismo de ação. Palavras-chave: Echinacea purpurea. Infecções Respiratórias. Sistema Respiratório. Abstract Since its beginnings, mankind has been in the habit of using medicinal plants as a form of diseases treatment, especially when compared to those that affect the respiratory system, such as bacterial, viral and fungal infections. As it presents several pharmacological properties, one of the most used species in these situations is the Echinacea purpurea. Thus, the aim of the present study was to review the available literature on the pharmacological potential of the species of Echinacea purpurea and its use against respiratory infections. The study was an exploratory qualitative study with a literature review. The searches were carried out between April 30th and July 31st of the year 2020. The search keywords "Echinacea purpurea", "Constitution of E. purpurea", "Respiratory system" and "Respiratory infections" were used as search keywords. The searches were performed using databases such as PubMed, SciELO and Google Scholar, in Portuguese, English and Spanish. The study showed that Echinacea purpurea is a plant widely used in the treatment of various diseases, especially in cases of respiratory infections. It has great biological potential because it contains phytochemicals that have antibacterial, antiviral, antifungal and immunomodulatory activities. However, it is still necessary to carry out more detailed research about it, since not all of its constituents are known, the doses at which it proves effective in humans and its mechanism of action. Keywords: Echinacea purpurea. Respiratory Infections. Respiratory System.

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Potential of the Phytomedicine Echinacea in the Treatment of Pulmonary Infections and Bronchitis

Cited by 4 publications

References 29 publications

Active compounds and biological activity of in vitro cultures of some Echinacea purpurea varieties

Active compounds and biological activity of in vitro cultures of some Echinacea purpurea varieties

Applications of the PhytomedicineEchinacea purpurea(Purple Coneflower) in Infectious Diseases

Uma Revisão Sobre o Potencial Farmacológico da Echinacea purpurea (L.) Moench Frente às Infeções Respiratórias

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