Potential of Taming MicroRNA on Driver Seat to Control Mitochondrial Horses in Breast Carcinoma

Purohit, Shruti; Jahagirdar, Devashree; Kumar, Azad; Sharma, Nilesh Kumar

doi:10.2174/2211536605666160727104405

Cited by 1 publication

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“…Giampazolias and Tait [ 44 ] reported the contributions of mitochondria to these hallmarks highlighting the impact of this organelle in tumour cell biology. In this background, mitomiRs arise as a vital regulator of mitochondrial functionality, and their alterations have been found in many pathologies, including breast cancer [ 45 , 46 , 47 , 48 ]. This review considers current understanding of the role of these mitomiRs in breast cancer and discusses their prospects as targets of adjuvant therapy or as precision biomarkers in these tumours.…”

Section: Micrornas In Breast Cancermentioning

confidence: 99%

The Regulatory Role of Mitochondrial MicroRNAs (MitomiRs) in Breast Cancer: Translational Implications Present and Future

Ortega

Fraile-Martínez

Guijarro

et al. 2020

Cancers

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Breast cancer is the most prevalent and incident female neoplasm worldwide. Although survival rates have considerably improved, it is still the leading cause of cancer-related mortality in women. MicroRNAs are small non-coding RNA molecules that regulate the posttranscriptional expression of a wide variety of genes. Although it is usually located in the cytoplasm, several studies have detected a regulatory role of microRNAs in other cell compartments such as the nucleus or mitochondrion, known as “mitomiRs”. MitomiRs are essential modulators of mitochondrion tasks and their abnormal expression has been linked to the aetiology of several human diseases related to mitochondrial dysfunction, including breast cancer. This review aims to examine basic knowledge of the role of mitomiRs in breast cancer and discusses their prospects as biomarkers or therapeutic targets.

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