Potential of stem cells for treating infected Diabetic Foot Wounds and Ulcers: a systematic review

Amini, Abdollah; Chien, Sufan; Bayat, Mohammad

doi:10.1007/s11033-022-07721-6

Cited by 6 publications

(3 citation statements)

References 61 publications

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“…They have become an effective therapeutic approach for treating DF[ 56 ]. It is worth noting that controlled studies conducted using animal models indicated that combining stem cells with biostimulants (such as photobiomodulation) can reduce biofilm formation and expedite the healing of infected diabetic wounds[ 57 ]. Multiple randomized controlled trials have confirmed that stem cell therapy is a promising treatment for DF, as it can improve healing rates and reduce the amputation rate[ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

Shi,

Yuan,

et al. 2024

World J Stem Cells

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BACKGROUND Stem cell therapy has shown great potential for treating diabetic foot (DF). AIM To conduct a bibliometric analysis of studies on the use of stem cell therapy for DF over the past two decades, with the aim of depicting the current global research landscape, identifying the most influential research hotspots, and providing insights for future research directions. METHODS We searched the Web of Science Core Collection database for all relevant studies on the use of stem cell therapy in DF. Bibliometric analysis was carried out using CiteSpace, VOSviewer, and R (4.3.1) to identify the most notable studies. RESULTS A search was conducted to identify publications related to the use of stem cells for DF treatment. A total of 542 articles published from 2000 to 2023 were identified. The United States had published the most papers on this subject. In this field, Iran’s Shahid Beheshti University Medical Sciences demonstrated the highest productivity. Furthermore, Dr. Bayat from the same university has been an outstanding researcher in this field. Stem Cell Research & Therapy is the journal with the highest number of publications in this field. The main keywords were “diabetic foot ulcers,” “wound healing,” and “angiogenesis.” CONCLUSION This study systematically illustrated the advances in the use of stem cell therapy to treat DF over the past 23 years. Current research findings suggested that the hotspots in this field include stem cell dressings, exosomes, wound healing, and adipose-derived stem cells. Future research should also focus on the clinical translation of stem cell therapies for DF.

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Section: Discussionmentioning

confidence: 99%

Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

Shi,

Yuan,

et al. 2024

World J Stem Cells

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“…Stem Cell therapy could be an effective treatment for diabetic wounds[ 59 , 60 ], which contains endless medical value together with a wide scientific perspective accelerating diabetic wound healing. Stem cells have also demonstrated their therapeutic potential in the field even if infection is present[ 61 ]. However, there are still problems that need to be solved.…”

Section: Discussionmentioning

confidence: 99%

Progress and expectation of stem cell therapy for diabetic wound healing

Xu¹,

Ma²,

Li³

et al. 2023

World J Clin Cases

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Impaired wound healing presents great health risks to diabetics. Encouragingly, the current clinical successfully found out meaningful method to repair wound tissue, and stem cell therapy could be an effective method for diabetic wound healing with its ability to accelerate wound closure and avoid amputation. This minireview aims at introducing stem cell therapy for facilitating tissue repair in diabetic wounds, discussing the possible therapeutic mechanism and clinical application status and problems.

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“…High amounts of glucose in diabetic patients, which also results in dryness and fragility by infection, and eventually leads to wounds, can prolong wound healing. A diabetic foot ulcer is usually caused by a lack of blood sugar control, peripheral vascular disease, peripheral nephropathy, and immunosuppression [19].…”

Section: Diabeticmentioning

confidence: 99%

The capacity of stem cells in treatment of diabetes

Fazeli

Ahanjan

2022

Cell. Mol. Biomed. Rep.

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Diabetes, a chronic metabolic disease, is recognized as the most frequent disorder in the endocrine system with hyperglycemia dealing with either insulin resistance or insufficiency or both. This disease is usually associated with numerous acute and chronic complications. Also, the treatment of diabetes complications has imposed a heavy financial burden on most societies. During the last decade, pancreatic islet transplantation has been widely studied as a potential therapy for diabetes. Of course, due to its limitations removing pancreatic cells from the corpse is very difficult. Stem cells are renewable cellular sources that are proposed as a substitute for organ transplantation. These cells which can be found in almost all multicellular organisms are capable of division and transforming into highly specialized cells, they can also replace injured and lost cells. The possibility of using stem cells in diabetes therapy and building insulin-producing islets has long been considered by most scientists and can be a future hope for controlling diabetes. Interestingly, human stem cells derived from hematopoietic organs, liver, pancreas, and embryonic human stem cells are among these factors. In this article, a series of studies carried out on this field is briefly reviewed.

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Potential of stem cells for treating infected Diabetic Foot Wounds and Ulcers: a systematic review

Cited by 6 publications

References 61 publications

Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives

Progress and expectation of stem cell therapy for diabetic wound healing

The capacity of stem cells in treatment of diabetes

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