Potential of Sonophoresis as a Skin Penetration Technique in the Treatment of Rheumatoid Arthritis with Transdermal Patch

Vaidya, Jai; Shende, Pravin

doi:10.1208/s12249-020-01725-w

Cited by 21 publications

(8 citation statements)

References 17 publications

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“…Thus, this method is applicable to humans, and it has a large variety of applications such as pain management, dermatology, and cosmeceuticals. [39,40,232,196] For example, a stretchable electronic facial mask (SEFM) with piezoelectric components was fabricated to be used for delivering ultrasound waves for facial healthcare purposes (Figure 5g). [39] The SEFM was designed to form conformal contact with the entire surface of the complex structure of the human face to maximize the propagation efficiency of ultrasound waves.…”

Section: Sonophoresismentioning

confidence: 99%

“…This review article provides a comprehensive overview of skinmediated drug delivery systems and the various techniques and mechanisms used to enhance drug permeation through the skin. The skin, being a formidable barrier, presents significant Low to high [39,40,128,130,196,232] challenges for drug delivery, but through innovative approaches, substantial progress has been made to overcome the barrier associated with the skin. One prominent strategy highlighted in this review is the chemical or physical modification of the stratum corneum, the outermost layer of the skin, which plays a pivotal role in drug permeation.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

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Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications

Lee,

Lim,

Kwak

et al. 2023

Adv Healthcare Materials

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Skin‐mediated drug delivery methods currently are receiving significant attention as a promising approach for the enhanced delivery of drugs through the skin. Skin‐mediated drug delivery offers the potential to overcome the limitations of traditional drug delivery methods, including oral administration and intravenous injection. The challenges associated with drug permeation through layers of skin, which act as a major barrier, are explored, and strategies to overcome these limitations are discussed in detail. This review categorizes skin‐mediated drug delivery methods based on the means of increasing drug permeation, and it provides a comprehensive overview of the mechanisms and techniques associated with these methods. In addition, recent advancements in the application of skin‐mediated drug delivery are presented. The review also outlines the limitations of ongoing research and suggests future perspectives of studies regarding the skin‐mediated delivery of drugs.

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Section: Sonophoresismentioning

confidence: 99%

Section: Conclusion and Prospectsmentioning

confidence: 99%

Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications

Lee,

Lim,

Kwak

et al. 2023

Adv Healthcare Materials

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“…The area under the curve of MTX-RV-HFMN (AUC 0-48h , 685.9 ± 157.9 nM.h) was 1.2 times that of the oral group, illustrating that MTX-RV-HFMN is an efficient transdermal drug delivery system. The strong mechanical properties of HFMN make the hydrogel microneedles could be completely removed from skin after 24 h use without tip residue and irritation at the application site, which exhibit its usage security (Tekko et al., 2020 ).…”

Section: Ra Transdermal Dosage Formmentioning

confidence: 99%

Transdermal delivery of inflammatory factors regulated drugs for rheumatoid arthritis

et al. 2022

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Rheumatoid arthritis is a chronic autoimmune disease, with the features of recurrent chronic inflammation of synovial tissue, destruction of cartilage, and bone erosion, which further affects joints tissue, organs, and systems, and eventually leads to irreversible joint deformities and body dysfunction. Therapeutic drugs for rheumatoid arthritis mainly reduce inflammation through regulating inflammatory factors. Transdermal administration is gradually being applied to the treatment of rheumatoid arthritis, which can allow the drug to overcome the skin stratum corneum barrier, reduce gastrointestinal side effects, and avoid the first-pass effect, thus improving bioavailability and relieving inflammation. This paper reviewed the latest research progress of transdermal drug delivery in the treatment of rheumatoid arthritis, and discussed in detail the dosage forms such as gel (microemulsion gel, nanoemulsion gel, nanomicelle gel, sanaplastic nano-vesiclegel, ethosomal gel, transfersomal gel, nanoparticles gel), patch, drug microneedles, nanostructured lipid carrier, transfersomes, lyotropic liquid crystal, and drug loaded electrospinning nanofibers, which provide inspiration for the rich dosage forms of transdermal drug delivery systems for rheumatoid arthritis.

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“…A variety of physical methods have also been used to increase drug flux across the stratum corneum. One of these methods is sonophoresis [ 67 , 68 , 69 ]. In this technique, low-frequency ultrasound increases the vibrational energy of the lipid molecules in the stratum corneum, thereby causing fluidization and increased permeability.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa

Wertz

2021

IJMS

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PubMed searches reveal much literature regarding lipids in barrier function of skin and less literature on lipids in barrier function of the oral mucosa. In terrestrial mammals, birds, and reptiles, the skin’s permeability barrier is provided by ceramides, fatty acids, and cholesterol in the outermost layers of the epidermis, the stratum corneum. This layer consists of about 10–20 layers of cornified cells embedded in a lipid matrix. It effectively prevents loss of water and electrolytes from the underlying tissue, and it limits the penetration of potentially harmful substances from the environment. In the oral cavity, the regions of the gingiva and hard palate are covered by keratinized epithelia that much resemble the epidermis. The oral stratum corneum contains a lipid mixture similar to that in the epidermal stratum corneum but in lower amounts and is accordingly more permeable. The superficial regions of the nonkeratinized oral epithelia also provide a permeability barrier. These epithelial regions do contain ceramides, cholesterol, and free fatty acids, which may underlie barrier function. The oral epithelial permeability barriers primarily protect the underlying tissue by preventing the penetration of potentially toxic substances, including microbial products. Transdermal drug delivery, buccal absorption, and lipid-related disease are discussed.

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Potential of Sonophoresis as a Skin Penetration Technique in the Treatment of Rheumatoid Arthritis with Transdermal Patch

Cited by 21 publications

References 17 publications

Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications

Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications

Transdermal delivery of inflammatory factors regulated drugs for rheumatoid arthritis

Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa

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