Potential of poly(alkylene terephthalate)s to control endothelial cell adhesion and viability

Catalyst-Free Single-Step Solution Polycondensation of Polyesters: Toward High Molar Masses and Control over the Molar Mass Range

“…Recently, however, these materials have been investigated for their use in cardiovascular applications. Because of the lower Young’s moduli of PATs (i.e., <1 GPa) compared to PET, PTT, and PBT (i.e., >1 GPa), as well as their potential as substrates for vascular endothelial cells, these materials have shown great potential for biomedical applications (e.g., as a coronary artery bypass graft). ,− Another added benefit of PATs with longer alkyl chain lengths is that they typically have lower melting temperatures than PET, PTT, and PBT, allowing for melt-processing at lower temperatures (i.e., <180 °C compared to >240 °C for PET, PTT, and PBT). ,− Notwithstanding these recent developments, the thermomechanical and other properties of PATs remain underinvestigated, leaving a lot of application potential unexplored.…”

Controlling differentiation of stem cells via bioactive disordered cues

“…RGD and BMP-2 mimetic peptides were used to favour MSC adhesion and differentiation into an osteoblast lineage, respectively. 19,61,62 As extracellular matrix-derived peptides, they are both involved in a synergic manner in MSC osteogenic differentiation. 9,56 In the present study, we synthesized micro/nanopatterned PET with different bioactive pattern sizes, surface coverage, and pattern shapes.…”

“…RGD and BMP-2 mimetic peptides were used to favour MSC adhesion and differentiation into an osteoblast lineage, respectively. 19,61,62 As extracellular matrix-derived peptides, they are both involved in a synergic manner in MSC osteogenic differentiation. 9,56…”

Effect of molar mass and alkyl chain length on the surface properties and biocompatibility of poly(alkylene terephthalate)s for potential cardiovascular applications

“…These polymers possess longer aliphatic chains compared to PET (n = 2), leading to a higher flexibility of the polymer chain, so the elasticity is increased accordingly. [36][37][38] In principle, the resulting lower stiffness of these polymers (i.e. Young's modulus below 500 MPa compared to 2.0-5.3 GPa for PET) 37 should lead to improved vascular endothelial cell viability and functionality when compared to PET/Dacron s .…”

“…thermal processing at lower temperatures). [37][38][39] We previously developed a novel one-step synthesis method by which PATs can be synthesized via a relatively simple set-up, using milder reaction conditions than the conventional melt polycondensation approach and without using a catalyst or other additives. 39,40 By avoiding the harsh reaction conditions, the formation of potentially harmful side products (e.g.…”