Potential of Phage Display Antibody Technology for Cardiovascular Disease Immunotherapy

Yeoh, Soo Ghee; Sum, Jia-Siang; Lai, Jing Yi; Isa, W. Yus Haniff W.; Lim, Theam Soon

doi:10.1007/s12265-021-10169-x

Cited by 4 publications

(3 citation statements)

References 219 publications

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“…However, these methods are constrained by limitations and potential side effects, rendering them insufficient to substantially mitigate disability. Phage therapy introduces a novel avenue for enhancing stroke recovery ( 104 , 123 ). Patients facing diseases lacking effective cures are increasingly exploring bacteriophage therapy, even driving medical tourism.…”

Section: Discussionmentioning

confidence: 99%

“…In summary, bacteriophage therapy presents new opportunities for promoting stroke recovery. While there are currently no clinical cases using bacteriophage therapy for stroke treatment, we believe that with advancements in scientific technology and further research, this approach has the potential to become a therapeutic option in the field of stroke treatment ( 104 ), significantly improving patients’ health and quality of life. Nevertheless, continuous exploration and relentless efforts are still required.…”

Section: Filamentous Bacteriophage Potential Therapy For Stroke Recoverymentioning

confidence: 99%

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Harnessing filamentous phages for enhanced stroke recovery

Li,

Yang,

Kong

et al. 2024

Front. Immunol.

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Stroke poses a critical global health challenge, leading to substantial morbidity and mortality. Existing treatments often miss vital timeframes and encounter limitations due to adverse effects, prompting the pursuit of innovative approaches to restore compromised brain function. This review explores the potential of filamentous phages in enhancing stroke recovery. Initially antimicrobial-centric, bacteriophage therapy has evolved into a regenerative solution. We explore the diverse role of filamentous phages in post-stroke neurological restoration, emphasizing their ability to integrate peptides into phage coat proteins, thereby facilitating recovery. Experimental evidence supports their efficacy in alleviating post-stroke complications, immune modulation, and tissue regeneration. However, rigorous clinical validation is essential to address challenges like dosing and administration routes. Additionally, genetic modification enhances their potential as injectable biomaterials for complex brain tissue issues. This review emphasizes innovative strategies and the capacity of filamentous phages to contribute to enhanced stroke recovery, as opposed to serving as standalone treatment, particularly in addressing stroke-induced brain tissue damage.

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Section: Discussionmentioning

confidence: 99%

Section: Filamentous Bacteriophage Potential Therapy For Stroke Recoverymentioning

confidence: 99%

Harnessing filamentous phages for enhanced stroke recovery

Li,

Yang,

Kong

et al. 2024

Front. Immunol.

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“…T-helper 17 (Th17) cells play a significant role in the perpetuation of chronic inflammation and have been linked to heightened vulnerability to plaque formation [ 14 ]. Regulatory T cells, also known as Tregs, fulfill a crucial regulatory function within the immune response and possess the capability to suppress inflammation and promote plaque stabilization [ 15 ]. In addition to other immune cell subsets, such as natural killer (NK) cells and B cells, there is also a contribution to the inflammatory environment in cardiovascular disease (CVD).…”

Section: Reviewmentioning

confidence: 99%

Unlocking the Potential of Immunotherapy in Cardiovascular Disease: A Comprehensive Review of Applications and Future Directions

Jyotsna,

Ikram,

Nageeta

et al. 2023

Cureus

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Immunotherapy has emerged as a pioneering therapeutic approach that harnesses the immune system's abilities to combat diseases, particularly in the field of oncology where it has led to significant advancements. However, despite its significant impact in the field of oncology, the potential of immunotherapy in the context of cardiovascular disease (CVD) has not been thoroughly investigated. The purpose of this narrative review is to address the existing knowledge and potential uses of immunotherapy in the field of cardiovascular disease (CVD), with the intention of filling the existing gap in understanding. Furthermore, the review thoroughly examines the future prospects of this swiftly advancing field, providing insights into the aspects that necessitate further investigation and addressing the forthcoming challenges. The review is organized into four distinct sections to enhance comprehension. The first section introduces immunotherapy, presenting the fundamental concepts and principles. The second section explores the immunomodulatory mechanisms in cardiovascular disease (CVD), with a specific focus on the intricate interplay between the immune system and the development of cardiovascular pathogenesis. The utilization of immunotherapy in specific cardiovascular conditions will be examined, investigating the application of immunotherapy in the context of different cardiovascular diseases. The future prospects and challenges in immunotherapy for cardiovascular diseases will be discussed, highlighting the potential areas for future research and addressing the barriers that must be overcome to effectively implement immunotherapeutic interventions in the management of cardiovascular diseases.

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