Potential of natural products in combination with arsenic trioxide: Investigating cardioprotective effects and mechanisms

Wang, Jie; Liu, Yongmei; Hu, Jun; Chen, Cong

doi:10.1016/j.biopha.2023.114464

Cited by 5 publications

(2 citation statements)

References 223 publications

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“…In the last decade, dietary components have shown the ability to reduce the toxicity of environmental pollutants, and a rising body of scientific evidence indicates that phytoantioxidants, particularly flavonoids, play a part in preventing or reducing the damage caused by HMs, owing to their antioxidant and metal-chelating properties [2]. Phytochemicals were shown to mitigate HM-mediated toxicity [32], specifically from As [33,34], arsenic trioxide [35], Cd and Pb [36]. Many flavonoids, such as gossypin (3,5,8,3 ′ ,4 ′ -pentahydroxy-7-O-glucosyl flavone, originally isolated from Hibiscus vitifolius) and quercetin have recently gained attention for their potential role in reducing the accumulation of HMs in biological systems [30].…”

Section: Phytochemicals Used To Ameliorate Heavy Metal-induced Toxicitymentioning

confidence: 99%

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Ceramella,

De Maio,

Basile

et al. 2024

Foods

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Heavy metals (HMs) are natural elements present in the Earth’s crust, characterised by a high atomic mass and a density more than five times higher than water. Despite their origin from natural sources, extensive usage and processing of raw materials and their presence as silent poisons in our daily products and diets have drastically altered their biochemical balance, making them a threat to the environment and human health. Particularly, the food chain polluted with toxic metals represents a crucial route of human exposure. Therefore, the impact of HMs on human health has become a matter of concern because of the severe chronic effects induced by their excessive levels in the human body. Chelation therapy is an approved valid treatment for HM poisoning; however, despite the efficacy demonstrated by chelating agents, various dramatic side effects may occur. Numerous data demonstrate that dietary components and phytoantioxidants play a significant role in preventing or reducing the damage induced by HMs. This review summarises the role of various phytochemicals, plant and herbal extracts or probiotics in promoting human health by mitigating the toxic effects of different HMs.

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Section: Phytochemicals Used To Ameliorate Heavy Metal-induced Toxicitymentioning

confidence: 99%

Phytochemicals Involved in Mitigating Silent Toxicity Induced by Heavy Metals

Ceramella,

De Maio,

Basile

et al. 2024

Foods

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“…It is derived from Cephalotaxus and has anti-tumor activity [ 21 ]. In addition, as the therapeutic scope of ATO is often limited due to its cardiotoxicity and many natural medicines play a protective role in the treatment of ATO-induced cardiac side effects, natural medicines have broad prospects as cardioprotective agents against ATO-induced cardiac side effects [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Natural products as potential drug treatments for acute promyelocytic leukemia

Chen,

Ding

2024

Chin Med

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Acute promyelocytic leukemia (APL), which was once considered one of the deadliest types of leukemia, has become a curable malignancy since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) as clinical treatments. ATO, which has become the first-line therapeutic agent for APL, is derived from the natural mineral product arsenic, exemplifying an important role of natural products in the treatment of APL. Many other natural products, ranging from small-molecule compounds to herbal extracts, have also demonstrated great potential for the treatment and adjuvant therapy of APL. In this review, we summarize the natural products and representative components that have demonstrated biological activity for the treatment of APL. We also discuss future directions in better exploring their medicinal value, which may provide a reference for subsequent new drug development and combination therapy programs.

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