Potential of microneedle-assisted micro-particle delivery by gene guns: a review

Zhang, Dongwei; Das, Diganta Bhusan; Rielly, Chris D.

doi:10.3109/10717544.2013.864345

Cited by 47 publications

(27 citation statements)

References 141 publications

(191 reference statements)

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“…Moreover, there are many reports on the delivery of large molecules using microneedles patch. In addressing this issue, microneedle delivery was used to enhance permeation flux of lidocaine hydrochloride and the penetration depths of microparticles delivered by gene gun (Nayak et al, 2014b;Zhang et al, 2013Zhang et al, , 2014. Moreover, optimized ultrasound combined with microneedles to further increase the permeation rates was proposed (Han & Das, 2013;Nayak et al, 2014a).…”

Section: Introductionmentioning

confidence: 99%

Penetration depth, concentration and efficiency of transdermal α-arbutin delivery after ultrasound treatment with albumin-shelled microbubbles in mice

Liao

Wang

et al. 2014

Drug Delivery

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Penetration depth, concentration and efficiency of transdermal α-arbutin delivery after ultrasound treatment with albumin-shelled microbubbles in mice, Drug Delivery, 23:7, 2173-2182, DOI: 10.3109/10717544.2014 AbstractRecently, the feasibility and effects of using microbubbles (MBs) as an ultrasound (US) contrast agent for enhancing the penetration in transdermal delivery in vivo have been demonstrated, but the mechanism and efficiency are unclear. This study demonstrates the penetration depth, concentration and efficiency of transdermal a-arbutin delivery during 4 weeks after US treatment with MBs in mice. Experimental animals were randomly divided into the following four groups (n ¼ 5 animals per group): (1) penetrating a-arbutin alone (C), (2) US combined with penetrating a-arbutin, (3) US combined with MBs and penetrating a-arbutin, and (4) US combined with diluted MBs and penetrating a-arbutin (UBD). The penetration depths in agarose phantoms and pigskin were 47 and 84% greater for group UBD, respectively, than for group C. The in vitro skin penetration by 2% a-arbutin after 3 h was 83% greater in group UBD than in group C. The degree of in vivo skin whitening (quantified as the luminosity index) in group UBD significantly increased by 25% after 1 week, 34% after 2 weeks, and then stabilized after 3 weeks at 37% in C57BL/6J mice over a 4-week experimental period. Our results indicate that combined treatment with optimal US and MBs can increase skin permeability so as to enhance a-arbutin delivery to inhibit melanogenesis without damaging the skin in mice.

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Section: Introductionmentioning

confidence: 99%

Penetration depth, concentration and efficiency of transdermal α-arbutin delivery after ultrasound treatment with albumin-shelled microbubbles in mice

Liao

Wang

et al. 2014

Drug Delivery

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“…TDD is developing fast and there are now many approved drugs for TDD, 34 e.g., nineteen (19) drugs have been approved by the Food and Drug Administration, USA [1]. 35 The potential of TDD for treating human diseases is also huge. For example, TDD can 36 provide prolonged treatment time in the cure of chronic diseases while maintaining the 37 permeation of the active drug molecules at a controlled level [2].…”

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confidence: 99%

Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: A review

Han

Das

2015

European Journal of Pharmaceutics and Biopharmaceutics

116

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Citation: HAN, T. and DAS, D.B., 2015. Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: a review. European Journal of Pharmaceutics and Biopharmaceutics,89, Additional Information:• NOTICE: this is the author's version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive ver- have been developed to overcome the resistance of the stratum corneum to molecular 10 diffusion. In particular, researchers have started to consider the possibility of combining the 11 TDD technologies in order to have further increase in drug permeability. Microneedles (MNs) 12 and ultrasound are both promising technologies. They achieve enhancement in drug 13 permeation via different mechanisms and therefore give a good potential for combining with 14 each other. This review will focus on discussing the potential of this combinational technique 15 along with other important issues, e.g., the mechanisms of ultrasound and MNs as it is these 16 mechanisms which are coupled via the two systems (i.e. MNs and ultrasound). We discuss 17 the possible ways to achieve this combination as well as how this combination would 18 increase the permeability. Some of the undeveloped (weaker) research areas of MNs and 19 sonophoresis are also discussed in order to understand the true potential of combining the two 20 technologies when they are developed further in the future. We propose several hypothetical 21 combinations based on the possible mechanisms involved in MNs and ultrasound. 22Furthermore, we carry out a cluster analysis by which we determine the significance of this 23Page 2 of 54 combinational method in comparison with some other selected combinational methods for 24 TDD (e.g., MNs and iontophoresis). Using a time series analysis tool (ARIMA model), the 25 current trend and the future development of combined MNs and ultrasound are also analysed. 26Overall, the review in this paper indicates that combining MNs and ultrasound is a promising 27 TDD method for the future. 28

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“…The potential of a system that combines MNs and gene guns has been discussed in details by Zhang et al (2013b).…”

Section: Introductionmentioning

confidence: 99%

“…Williams et al (1991) used a helium-driven apparatus to study 3.9 mm average diameter tungsten and of golden particles, with a diameter ranged from 2 to 5 mm, on mouse liver. Recently, the review paper by Zhang et al (2013b) discussed the importance of particle characteristics and operation condition on the delivery of the microparticles in detail.…”

Section: Introductionmentioning

confidence: 99%

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Microneedle-assisted microparticle delivery by gene guns: experiments and modeling on the effects of particle characteristics

2014

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Microneedles (MNs) have been shown to enhance the penetration depths of microparticles delivered by gene gun. This study aims to investigate the penetration of model microparticle materials, namely, tungsten (51 mm diameter) and stainless steel (18 and 30 mm diameters) into a skin mimicking agarose gel to determine the effects of particle characteristics (mainly particle size). A number of experiments have been processed to analyze the passage percentage and the penetration depth of these microparticles in relation to the operating pressures and MN lengths. A comparison between the stainless steel and tungsten microparticles has been discussed, e.g. passage percentage, penetration depth. The passage percentage of tungsten microparticles is found to be less than the stainless steel. It is worth mentioning that the tungsten microparticles present unfavourable results which show that they cannot penetrate into the skin mimicking agarose gel without the help of MN due to insufficient momentum due to the smaller particle size. This condition does not occur for stainless steel microparticles. In order to further understand the penetration of the microparticles, a mathematical model has been built based on the experimental set up. The penetration depth of the microparticles is analyzed in relation to the size, operating pressure and MN length for conditions that cannot be obtained in the experiments. In addition, the penetration depth difference between stainless steel and tungsten microparticles is studied using the developed model to further understand the effect of an increased particle density and size on the penetration depth.

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Potential of microneedle-assisted micro-particle delivery by gene guns: a review

Cited by 47 publications

References 141 publications

Penetration depth, concentration and efficiency of transdermal α-arbutin delivery after ultrasound treatment with albumin-shelled microbubbles in mice

Penetration depth, concentration and efficiency of transdermal α-arbutin delivery after ultrasound treatment with albumin-shelled microbubbles in mice

Potential of combined ultrasound and microneedles for enhanced transdermal drug permeation: A review

Microneedle-assisted microparticle delivery by gene guns: experiments and modeling on the effects of particle characteristics

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