Potential of medicinal plants in management of diabetes: An updates

Malode, Lochana L.; Manwar, Jagdish V.; Panchale, Wrushali A.; Bartere, Shivam A.; Bakal, Ravindra L.

doi:10.30574/gscarr.2021.8.1.0151

Cited by 8 publications

(3 citation statements)

References 29 publications

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“…The antidiabetic activities of these medicinal plants and vitamins are attributed to the presence of coumarins, flavonoids, polyphenols, terpenoids, and other bioactive compounds which exert their effects through the reduction in blood glucose levels. The administration of medicinal plants and vitamins in proper dosages has been demonstrated to lower fasting blood sugar levels in people with diabetes, improve blood circulation and promote wound healing in people with diabetes, and ameliorate complications associated with diabetes [120,121]. Hence, great efforts should be made to increase awareness about the health benefits of medicinal plants and vitamins in the cost-effective prevention and treatment of DM patients; especially those in developing countries who cannot afford the high costs of modern medicine.…”

Section: Discussionmentioning

confidence: 99%

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins

Yedjou,

Grigsby,

Mbemi

et al. 2023

IJMS

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Diabetes mellitus (DM) is a serious chronic metabolic disease that is associated with hyperglycemia and several complications including cardiovascular disease and chronic kidney disease. DM is caused by high levels of blood sugar in the body associated with the disruption of insulin metabolism and homeostasis. Over time, DM can induce life-threatening health problems such as blindness, heart disease, kidney damage, and stroke. Although the cure of DM has improved over the past decades, its morbidity and mortality rates remain high. Hence, new therapeutic strategies are needed to overcome the burden of this disease. One such prevention and treatment strategy that is easily accessible to diabetic patients at low cost is the use of medicinal plants, vitamins, and essential elements. The research objective of this review article is to study DM and explore its treatment modalities based on medicinal plants and vitamins. To achieve our objective, we searched scientific databases of ongoing trials in PubMed Central, Medline databases, and Google Scholar websites. We also searched databases on World Health Organization International Clinical Trials Registry Platform to collect relevant papers. Results of numerous scientific investigations revealed that phytochemicals present in medicinal plants (Allium sativum, Momordica charantia, Hibiscus sabdariffa L., and Zingiber officinale) possess anti-hypoglycemic activities and show promise for the prevention and/or control of DM. Results also revealed that intake of vitamins C, D, E, or their combination improves the health of diabetes patients by reducing blood glucose, inflammation, lipid peroxidation, and blood pressure levels. However, very limited studies have addressed the health benefits of medicinal plants and vitamins as chemo-therapeutic/preventive agents for the management of DM. This review paper aims at addressing this knowledge gap by studying DM and highlighting the biomedical significance of the most potent medicinal plants and vitamins with hypoglycemic properties that show a great potential to prevent and/or treat DM.

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Section: Discussionmentioning

confidence: 99%

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins

Yedjou,

Grigsby,

Mbemi

et al. 2023

IJMS

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“…Bioavailability of phenolic compounds is limited due to their less water solubility and instability at low pH values (Malode et al, 2021 ). The bioavailability of polyphenols can be increased by using nanoparticles (Irshad et al, 2020 ).…”

Section: Plant‐derived Bioactive Compounds and Their Therapeutic Pote...mentioning

confidence: 99%

Phytobioactive compounds as therapeutic agents for human diseases: A review

Riaz

Khalid

Afzal³

et al. 2023

Food Science & Nutrition

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Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present‐day ailments such as diabetes, atherosclerosis, cardiovascular disorders, cancer, and inflammation. The data for this review were collected from Google Scholar, PubMed, Directory of Open Access Journals (DOAJ), and Science Direct by using keywords: “Medicinal plants, Phytobioactive compounds, Polyphenols, Alkaloids, Carotenoids etc.” Several studies have reported the pharmacological and therapeutic potential of the phytobioactives. Polyphenols, alkaloids, terpenes, and polysaccharides isolated from medicinal plants showed remarkable antioxidant, anticancer, cytotoxic, anti‐inflammatory, cardioprotective, hepatoprotective, immunomodulatory, neuroprotective, and antidiabetic activities. This literature review was planned to provide comprehensive insight into the biopharmacological and therapeutic potential of phytobioactive compounds. The techniques used for the extraction and isolation of phytobioactive compounds, and bioassays required for their biological activities such as antioxidant, antimicrobial, anti‐inflammatory, and cytotoxic activities, have been discussed. Characterization techniques for the structural elucidation of phytobioactive compounds such as HPLC, TLC, FTIR, GC–MS/MS, and NMR have also been discussed. This review concludes that phytobioactive compounds may be used as potential alternative to synthetic compounds as therapeutic agents for the treatment of various diseases.

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“…Type 1 diabetes is an autoimmune disease, wherein beta cells in the pancreas are destroyed by the immune system, resulting in absolute insulin deficiency, while Type 2 diabetes results from insulin resistance and the progressive loss of insulin secretion. In contrast, gestational diabetes occurs during pregnancy [5]. Type 2 DM is the most common health burden, particularly in the elderly population, affecting approximately 25% of people over the age of 65 years as of 2021, with the number of affected people expected to increase drastically over the next decades owing to increased life expectancy [6].…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

Zanzabil,

Hossain,

Hasan

2023

Diabetology

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Plants have been used as sources of medicine since ancient times. Natural products have been used extensively in Chinese, ayurvedic and folk medicine. In addition, a significant portion of the world’s population still utilizes herbal medicine. Diabetes is a common ailment affecting almost 463 million people in the world. However, current medications exert harmful after-effects on patients, while herbal medicines have fewer adverse effects. Plants possess secondary metabolites, such as alkaloids, flavonoids, tannins, steroids, etc., which exert numerous beneficial effects on health. Extensive research has been conducted over the years investigating and proving the hypoglycemic potential of various plants. The present paper reviews 37 such plants that are rich in phytoconstituents that possess a variety of pharmacological activities and have been experimentally proven to possess potentially hypoglycemic properties in animal models: Ficus racemosa, Agremone mexicana, Bombax ceiba, Cajanus cajan, Coccinia cordifolia, Momordica charantia, Syzygium cumini, Neolamarckia cadamba, Mangifera indica, Cocos nucifera, Tamarindus indica, Punica granatum, Azadirachta indica, Costus speciosus, Moringa oleifera, Andrographis paniculata, Ficus benghalensis, Anacardium occidentale, Annona squamosa, Boerhaavia diffusa, Catharanthus roseus, Cocculus hirsutus, Ficus hispida, Terminalia chebula, Terminalia catappa, Amaranthus tricolor, Blumea lacera, Piper betle leaves, Achyranthes aspera, Kalanchoe pinnata, Nelumbo nucifera, Mikania cordata, Wedelia chinensis, Murraya koenigii, Aloe barbadensis, Bryophyllum pinnatum and Asparagus racemosus. These 37 plant extracts exhibit antidiabetic activities through different mechanisms, including α-amylase and α-glucosidase inhibition, increases in glucose uptake and the stimulation of insulin secretion.

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Potential of medicinal plants in management of diabetes: An updates

Cited by 8 publications

References 29 publications

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins

Phytobioactive compounds as therapeutic agents for human diseases: A review

Diabetes Mellitus Management: An Extensive Review of 37 Medicinal Plants

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