Potential of Magnetic Resonance Spectroscopy in Assessing the Effect of Fatty Acids on Inflammatory Bowel Disease in an Animal Model

Varma, Sonal; Eskin, Michael; Bird, Ranjana P.; Dolenko, Brion; Raju, Jayadev; Ijare, Omkar B.; Bezabeh, Tedros

doi:10.1007/s11745-010-3455-7

Cited by 10 publications

(11 citation statements)

References 44 publications

(21 reference statements)

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“…Eicosanoids are one of the many mediators of inflammation examples of which include prostaglandins, prostacyclin, thromboxane, and leukotrienes ( Figure 2) (Cotran, 2010). These are all byproducts of the arachidonic acid (AA; 20:4 ω-6 or eicosatetraenoic acid) oxidation pathway (Varma et al, 2010). Two principal enzymes within the arachidonic acid oxygenation pathway are the cyclo-oxygenases (COX1 and COX2) which produce prostaglandins (PGs) and the 5-lipoxygenase (LOX) which produces leukotrienes (LTs) (Chan et al, 2000).…”

Section: Anti-inflammatory Mechanism Of Actionmentioning

confidence: 99%

“…The type of prostaglandin produced or at least increased or decreased has a critical role in determining the direction that a large variety of biological activities are going take especially those concerned with the clotting cascade, platelet aggregation, vasodilation, neutrophil migration, bronchospasm, and pain (Cotran, 2010). While PGE2 is one of the key prostaglandins with significant pro-inflammatory effects, omega-3 FAs on the other hand can result in a reduction in PGE2 by having the enzyme use a different precursor for its activities (Varma et al, 2010). In addition, omega-3 FAs (e.g.…”

Section: Anti-inflammatory Mechanism Of Actionmentioning

confidence: 99%

“…A study of magnetic resonance spectroscopy conducted by (Varma et al, 2010) assessed the effects of fatty acids on inflammatory bowel disease in Sprague-Dawley rats. The fatty acids studied were: high-fat beef tallow (saturated fatty acids), high-fat corn oil (omega-6) and high-fat flaxseed oil (omega-3).…”

Section: Anti-inflammatory Mechanism Of Actionmentioning

confidence: 99%

“…Initially, half of the animals were fed 2% carrageenan to induce colonic inflammation. The study showed that high-fat corn oil had the most inflammatory effects and high-fat flaxseed oil the least (Varma et al, 2010). In addition, antidiabetic activity of purslane seeds studied by (El-Sayed, M.I.…”

Section: Anti-inflammatory Mechanism Of Actionmentioning

confidence: 99%

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Redefining Unusable Weeds to Beneficial Plants: Purslane as a Powerful Source of Omega-3 for the Future

Agil¹,

Gilbert²,

Tavakoli³

et al. 2015

JFR

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With global consumer demand shifting towards the consumption of healthier foods, it is crucial to discover new sources of edible plants with high nutritional value and low cost. Unique weeds such as purslane have the potential to be used as an untapped source of unconventional food with diverse nutrients and beneficial bioactive properties. Inflammation can cause oxidative stress related diseases including cardiovascular disorders, aging and cancer. One key nutrient of purslane is omega-3 with potential of inhibitory properties against inflammatory and estrogenic mediators. Purslane is known to be a rich source of α-linolenic acid, 18:3 ω-3, an essential fatty acid, carotenes, antioxidants and minerals. However, the precise mechanism of action of its individual components in disease prevention is unknown. This review provides a summary on the role of purslane bioactives, particularly omega-3 fatty acids as one of purslane's main constituents with potential of anti-inflammatory and anti-estrogenic properties. The discovery of new sources of plants rich in omega-3 fatty acids may be a useful strategy in utilizing natural alternative sources of foods that can enhance human health and wellbeing.

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Section: Anti-inflammatory Mechanism Of Actionmentioning

confidence: 99%

Section: Anti-inflammatory Mechanism Of Actionmentioning

confidence: 99%

Section: Anti-inflammatory Mechanism Of Actionmentioning

confidence: 99%

Section: Anti-inflammatory Mechanism Of Actionmentioning

confidence: 99%

See 2 more Smart Citations

Redefining Unusable Weeds to Beneficial Plants: Purslane as a Powerful Source of Omega-3 for the Future

Agil¹,

Gilbert²,

Tavakoli³

et al. 2015

JFR

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“…Sin embargo, la toxicidad cardiovascular de los inhibidores de la COX-2 ha puesto en peligro su utilidad clínica (47). Reducir la ingesta de AGPI omega-6 y aumentar la ingesta de AGPI omega-3 en la dieta podría ser una intervención atractiva para reducir la producción de eicosanoides pro-inflamatorios y prevenir el desarrollo del cáncer (48).…”

Section: Agpicl Omega-3 En La Prevenciónunclassified

Ácidos Grasos Omega-3 Y Cáncer, Una Alternativa Nutricional Para Su Prevención Y Tratamiento

et al. 2011

Rev. chil. nutr.

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INTRODUCCIÓNEn los países occidentales, las enfermedades cardiovasculares (ECV), el cáncer (Ca), la obesidad (Ob) y la diabetes tipo 2 (DM2), son responsables de más del 80% de la mortalidad (1). Se ha propuesto que los lípidos desempeñarían un papel decisivo en el desarrollo de éstas enfermedades, particularmente en referencia a la cantidad y tipo de ácidos grasos (AG) aportados por la dieta.La ingesta total de lípidos, así como la relación en el consumo de ácidos grasos poliinsaturados (AGPI) de cadena larga (AGPICL) omega-6/omega-3, ha aumentado considerablemente en la dieta occidental en las últimas décadas (2). Es ya conocido que la dieta estándar actual difiere sustancialmente de aquella que consumieron los seres humanos desde tiempos prehistóricos (3). Por otro lado, está relativamente bien documentado el efecto preventivo de los AGPICL omega-3 en las ECV, ciertos ABSTRACT Long-chain omega-3 polyunsaturated fatty acids (omega-3 LCPUFA) are essential for human beings and they should be incorporated to our body through the diet. For almost a century it is known that these fatty acids are essential for growth and development of individuals and from 1970 onwards, investigations have found solid evidence about several health properties attributed to these fatty acids, especially at the cardiovascular, neurological and anti-inflammatory level; it is in this sense that today a large number of investigations have focused to study the protective role of omega-3 LCPUFA against cancer, primarily based on the anti-inflammatory properties that they possess. In this paper we describe a series of evidences to establish a possible preventive and therapeutic use of omega-3 LCPUFA against cancer, specifically in prostate, breast and colon cancer. Key words: cancer, fatty acids, omega-3 fatty acids, anti-inflammatory effect.Este trabajo fue recibido el 13 de Diciembre de 2010 y aceptado para ser publicado el 10 de Mayo de 2011.Ca, DM2 y en el síndrome metabólico (SM), a través de información derivada tanto de estudios clínicos como epidemiológicos (4,5).Si bien el efecto del medio ambiente en la expresión de los genes es aún controversial, existe certeza que la dieta puede modificar la expresión de nuestro patrimonio genético, afectando tanto en forma positiva, como también negativa, en la salud de los seres humanos (6). Es más, en relación a nutrientes como los lípidos, se sabe que la cantidad y el tipo específico de estos en la dieta, puede tener un impacto marcado y diferencial en la salud de animales con la misma base genética, incluyendo los humanos, así como en la salud de poblaciones predispuestas genéticamente (7 -9). En el presente trabajo se expone una visión general sobre los beneficios de los AGPICL omega-3 de origen dietario, en relación a su posible efecto preventivo en el desarrollo de ciertos Ca,

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Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

Cruz

Prideaux

Wagner

et al. 2012

Inflammatory Bowel Diseases

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The enteric bacterial flora play a key role in maintaining health. Inflammatory bowel disease is associated with quantitative and qualitative alterations in the microbiota. Early characterization of the microbiota involved culture-dependent techniques. The advent of metagenomic techniques, however, allows for structural and functional characterization using culture-independent methods. Changes in diversity, together with quantitative alterations in specific bacterial species, have been identified. The functional significance of these changes, and their pathogenic role, remain to be elucidated.

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Potential of Magnetic Resonance Spectroscopy in Assessing the Effect of Fatty Acids on Inflammatory Bowel Disease in an Animal Model

Cited by 10 publications

References 44 publications

Redefining Unusable Weeds to Beneficial Plants: Purslane as a Powerful Source of Omega-3 for the Future

Redefining Unusable Weeds to Beneficial Plants: Purslane as a Powerful Source of Omega-3 for the Future

Ácidos Grasos Omega-3 Y Cáncer, Una Alternativa Nutricional Para Su Prevención Y Tratamiento

Characterization of the Gastrointestinal Microbiota in Health and Inflammatory Bowel Disease

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