Potential of interferon- -inducible protein 10 in improving tuberculosis diagnosis in HIV-infected patients

IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions

“…By contrast, a study in 65 HIV-infected TB patients from Tanzania found equal positivity rates for the tests (63% for both), which was significantly lower compared with HIV uninfected individuals (82 and 80%, respectively) [55].…”

“…One large study in 170 otherwise healthy HIV-infected individuals from a TB-endemic setting, found that very low IP-10 responses to mitogens (<200 pg/ml) only occurred in individuals with CD4 cell count <100 cells/µl [55]. However, comparisons of indeterm inate results are difficult to make due to the lack of a validated cutoff for an indeterminate IP-10 response (see below).…”

“…We identified three studies comprising a total of 143 HIVinfected TB patients, and these report rather divergent findings (TaBle 4) [55,56,73]. Two small studies from India, comprising a total of 78 HIV-infected TB patients, both found a marginally Table 4.…”

“…Increased when combining tests (71%) compared with either test alone. Negative trend of decreasing positivity rate with decreasing CD4 cell count for the QFT-IT, but not for the IP-10 test [55] Kabeer et al…”

“…Review were combined (available for four studies only; positivity rates increased to 86-93%) [52][53][54][55].…”