Potential of indocyanine green near-infrared fluorescence imaging in experimental and clinical practice

Papayan, G. V.; Akopov, Andrey

doi:10.1016/j.pdpdt.2018.10.011

Cited by 24 publications

(17 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…By means of ICG, lymphography, bile duct imaging, and mapping of sentinel nodes in different malignant tumors being performed; the blood supply quality of transplants, the leak integrity of vascular anastomoses, etc. being determined [ 45 – 48 ]. Characteristic ICG application is the necessity to excite and register fluorescence in near-infrared (NIR) spectrum that requires special equipment available [ 49 ].…”

Section: Theranostic Approachmentioning

confidence: 99%

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Papayan¹,

Akopov²

2021

Sovrem Tehnol Med

View full text Add to dashboard Cite

The aim of the study was to assess the prospects for central lung cancer (CLC) screening using fluorescent diagnostics and its treatment by endobronchial photodynamic therapy (PDT).Bronchoscopic fluorescent diagnostics using chlorin e6 photosensitizers and a developed instrumental system enable to reveal tumor changes in large bronchi mucosa at early stages, and a developed PDT technique performed under fluorescent control helps achieve personalized treatment. Such an approach is considered as a theranostic technique -photodynamic theranostics.Central lung cancer screening requires a fluorescent dye characterized by availability and can be used directly within the examination. Indocyanine green can be used as a dye, its peculiarity is the necessity to excite and record fluorescence in the near-infrared (NIR) wavelength band. First experiments using NIR bands to diagnose a bronchoscopic system showed the detectability of tumor areas using on-site bronchoscopic photodynamic theranostics, which consists in NIR imaging of tumor foci when a standard dose of indocyanine green is administered during the examination.Conclusion. Further progress of early diagnostics and minimally invasive CLC therapy will be determined by the development of new photosensitizers, which should be characterized by a high absorption band in NIR area, quick accumulation in a tumor, high yield of single oxygen in NIR illumination, bright fluorescence, high potential in terms of the induction of an anti-tumor immune response.

show abstract

Section: Theranostic Approachmentioning

confidence: 99%

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Papayan¹,

Akopov²

2021

Sovrem Tehnol Med

View full text Add to dashboard Cite

show abstract

“…В исследовании использована созданная в Центре лазерной медицины ПСПбГМУ с участием Российского научного центра в Сеуле (Республика Корея) и компании «ВОЛО» (Санкт-Петербург, Россия) система FLUM -808, подробная характеристика которой опубликована ранее [7]. В качестве флуоресцирующего агента применяли лиофилизат ИЦЗ (Pulsion medical systems, AG, Германия), растворенный в дистиллированной воде и смешанный с 20 %-м альбумином человека (АЧ) в пропорции, обеспечивавшей соотношение масс АЧ/ИЦЗ не менее 90, что по соотношению числа молекул соответствует 1:…”

Section: материалы и методы исследованияunclassified

“…Именно в связи с этим в данной работе на основе новой методики ИЦЗ лимфографии мы попытались определить группы ЛУ, куда наиболее часто оттекает лимфа от каждой доли легкого у больных НМРЛ. Эта технология открывает все больше возможностей для визуализации скрытых от невооруженного глаза изменений и анатомических деталей [6,7,17].…”

Section: результаты исследования и их обсуждениеunclassified

Intravital study of lymphatic drainage in lung cancer using indocyanine green

Akopov¹,

Папаян²,

Ильин³

2020

Regional blood circulation and microcirculation

View full text Add to dashboard Cite

Прижизненное изучение направления оттока лимфы при раке легкого с помощью индоцианина зеленого Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова»

show abstract

“…Compared to other imaging modalities, fluorescence imaging enables real-time, secure, and accurate visualization owing to its high sensitivity and non-radioactive nature. The FDA-approved and clinically accessible, small-molecule dyes, such as indocyanine green (ICG), have been successfully applied to SLN imaging ( Kraft et al, 2018 ; Papayan and Akopov, 2018 ). However, such molecule-based agents enter both lymphatic vessels and blood capillaries with no selectivity due to their small physical size (<2 nm).…”

Section: Introductionmentioning

confidence: 99%

Preparation of the Biodegradable Lymphatic Targeting Imaging Agent Based on the Indocyanine Green Mesoporous Silicon System

et al. 2022

View full text Add to dashboard Cite

The lymphatic system plays a crucial role in the immune system’s recognition and response to disease. Therefore, the imaging of the lymphatic system, especially lymphatic vessels, has emerged as a valuable tool for the diagnosis of metastasis. FDA-approved small-molecule dyes, namely, indocyanine green (ICG), have been widely applied to lymphatic vessels imaging. However, due to the small physical size, such molecule-based agents show no selectivity, and rapid clearance from lymph nodes. Herein, a biodegradable lymphatic targeting imaging agent based on the ICG-mesoporous silicon system (ICG@HMONs-HA) was obtained, which not only could target lymph vessels but also had a long residence time. The reported work provides a practical way for lymph vessel fluorescence imaging and paves the way for clinical translation of nanomaterial-based tracers.

show abstract

Potential of indocyanine green near-infrared fluorescence imaging in experimental and clinical practice

Cited by 24 publications

References 30 publications

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Photodynamic Theranostics of Central Lung Cancer: Capabilities of Early Diagnosis and Minimally Invasive Therapy (Review)

Intravital study of lymphatic drainage in lung cancer using indocyanine green

Preparation of the Biodegradable Lymphatic Targeting Imaging Agent Based on the Indocyanine Green Mesoporous Silicon System

Contact Info

Product

Resources

About