Potential of
            <i>Aedes albopictus</i>
            as a bridge vector for enzootic pathogens at the urban-forest interface in Brazil

Santos, Taissa Pereira dos; Roiz, David; Abreu, Filipe Vieira Santos de; Luz, Sérgio Luíz Bessa; Santalucia, Marcelo; Jiolle, Davy; Neves, Maycon Sebastião Alberto Santos; Simard, Frédéric; Lourenço‐de‐Oliveira, Ricardo; Paupy, Christophe

doi:10.1038/s41426-018-0194-y

Cited by 63 publications

(80 citation statements)

References 59 publications

(52 reference statements)

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“…Given the ecological plasticity and the ubiquitous environmental distribution of A. albopictus (in urban, rural, and forest settings in tropical countries, including Brazil), this mosquito could be a bridge vector between sylvatic and urban environments [89,93]. Experimental studies have demonstrated that A. albopictus can transmit YFV [77,[94][95][96], and it was found naturally infected with the virus, in a rural setting of Minas Gerais state, in 2018 [97].…”

Section: Yellow Fever Virus Vectors In Brazilmentioning

confidence: 99%

Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease

Silva

Sacchetto

Rezende

et al. 2020

Virol J

140

166

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Yellow fever (YF) is an acute viral disease, affecting humans and non-human primates (NHP), caused by the yellow fever virus (YFV). Despite the existence of a safe vaccine, YF continues to cause morbidity and mortality in thousands of people in Africa and South America. Since 2016, massive YF outbreaks have taken place in Brazil, reaching YF-free zones, causing thousands of deaths of humans and NHP. Here we reviewed the main epidemiological aspects, new clinical findings in humans, and issues regarding YFV infection in vectors and NHP in Brazil. The 2016-2019 YF epidemics have been considered the most significant outbreaks of the last 70 years in the country, and the number of human cases was 2.8 times higher than total cases in the previous 36 years. A new YFV lineage was associated with the recent outbreaks, with persistent circulation in Southeast Brazil until 2019. Due to the high number of infected patients, it was possible to evaluate severity and death predictors and new clinical features of YF. Haemagogus janthinomys and Haemagogus leucocelaenus were considered the primary vectors during the outbreaks, and no human case suggested the occurrence of the urban transmission cycle. YFV was detected in a variety of NHP specimens presenting viscerotropic disease, similar to that described experimentally. Further studies regarding NHP sensitivity to YFV, YF pathogenesis, and the duration of the immune response in NHP could contribute to YF surveillance, control, and future strategies for NHP conservation.

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Section: Yellow Fever Virus Vectors In Brazilmentioning

confidence: 99%

Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease

Silva

Sacchetto

Rezende

et al. 2020

Virol J

140

166

View full text Add to dashboard Cite

show abstract

“…The study found that vector density was highest at the forest edge and decreased significantly only 200-300 m into the forest. As the forest edge was close to an urban area, the study identified 75% of engorged mosquitoes at the forest edge as having fed from a human host rather than animal hosts [20]. A similar study done in Rio de Janiero, found an absence of Aedes aegypti or Aedes albopictus 100 m into the forest, again showing that Aedes spp.…”

Section: Introductionmentioning

confidence: 68%

“…All of these factors promote mosquito breeding and an acceleration of larval development from one to two weeks to as quickly as 4.5 days [13,40]. Similarly, Aedes mosquitoes prefer to inhabit forest edges rather than densely forested areas [20,21]. Therefore, increasing linear density creates more favorable breeding habitats for vectors of ZIKV.…”

Section: Discussionmentioning

confidence: 99%

Spatial Associations Between Land Use and Infectious Disease: Zika Virus in Colombia

Weinstein

Leslie

Fricken

2020

IJERPH

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Land use boundaries represent human-physical interfaces where risk of vector-borne disease transmission is elevated. Land development practices, coupled with rural and urban land fragmentation, increases the likelihood that immunologically naïve humans will encounter infectious vectors at land use interfaces. This research consolidated land use classes from the GLC-SHARE dataset; calculated landscape metrics in linear (edge) density, proportion abundance, and patch density; and derived the incidence rate ratios of the Zika virus occurrence in Colombia, South America during 2016. Negative binomial regression was used to evaluate vector-borne disease occurrence counts in relation to Population Density, Average Elevation, Per Capita Gross Domestic Product, and each of three landscape metrics. Each kilometer of border length per square kilometer of area increase in the linear density of the Cropland and Grassland classes is associated with an increase in Zika virus risk. These spatial associations inform a risk reduction approach to rural and urban morphology and land development that emphasizes simple and compact land use geometry that decreases habitat availability for mosquito vectors of Zika virus.

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“…Since Ae. albopictus is an opportunistic feeder, able to utilise a wide range of peri-domestic habitats outside of its native range (68,69), it could act as an efficient bridge vector for emergent zoonotic diseases from the forest (69). The addition of the specialised commensal Ae.…”

Section: Discussionmentioning

confidence: 99%

The impact of biological invasion and genomic local adaptation on the geographical distribution of Aedes aegypti in Panama

Bennett¹,

McMillan²,

Loaiza

2019

Preprint

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Local adaptation is an important consideration when predicting arthropod-borne disease risk because it can impact on individual vector fitness and vector population persistence. However, the extent that populations are adapted to local environmental conditions remains unknown. Here, we identified 128 candidate SNPs, clustered within 17 genes, which show a strong genetic signal of adaptation across Panama. Analysis of genome-wide SNPs showed that the local adaptation of Aedes aegypti mosquito populations occurs across relatively fine geographic scales. The composition and frequency of candidate adaptive loci differed between populations in wet tropical environments along the Caribbean coast and the dry tropical conditions typical of the Pacific coast of Panama. Temperature and vegetation were important predictors of adaptive genomic variation in Ae. aegypti with areas of local adaptation occurring within the Caribbean region of Bocas del Toro, the Pacific coastal areas of Herrera and Panama City and the eastern Azuero Peninsula. In addition, we found that the geographic distribution of Ae. aegypti across Panama is rapidly changing as a consequence of the recent invasion by its ecological competitor, Aedes albopictus. Although Ae. albopictus has displaced Ae. aegypti in some areas, species coexist across many areas, including regions where Ae. aegypti are locally adapted. Our results guide future experimental work by suggesting that adaptive variation within Ae. aegypti is affecting the outcome of inter-specific competition with Ae. albopictus and, as a consequence, may fundamentally alter future arborviral disease risk and efforts to control mosquito populations.

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Potential of Aedes albopictus as a bridge vector for enzootic pathogens at the urban-forest interface in Brazil

Cited by 63 publications

References 59 publications

Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease

Recent sylvatic yellow fever virus transmission in Brazil: the news from an old disease

Spatial Associations Between Land Use and Infectious Disease: Zika Virus in Colombia

The impact of biological invasion and genomic local adaptation on the geographical distribution of Aedes aegypti in Panama

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