Potential of Fructooligosaccharides and Xylooligosaccharides as Substrates To Counteract the Undesirable Effects of Several Antibiotics on Elder Fecal Microbiota: A First in Vitro Approach

Míguez, Beatriz; Gómez, Belén; Parajó, Juan Carlos; Alonso, José Luís

doi:10.1021/acs.jafc.8b02940

Cited by 26 publications

(31 citation statements)

References 54 publications

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“…The next step in the present study was to investigate whether dietary fiber preparations could potentially counteract the effects of amoxicillin on the microbiota. The effect of amoxicillin along with doxycycline and clindamycin on the gut microbiota as well as the potency of FOS and two types of XOS to minimize their negative effect has been investigated using in vitro static batch fermentation model similar to that we established [15]. The authors also found that amoxicillin affected the microbiota in fiber dependent manner.…”

Section: Discussionmentioning

confidence: 99%

“…Propionate has been shown to inhibit cholesterol synthesis and butyrate, additionally to serving as a fuel for colon epithelial cells, and has been proposed to play an important role as a protective agent against chronic intestinal inflammation [12,13,14]. In addition to the beneficial metabolites from dietary fibers, prebiotic fibers could potentially reduce the negative effect of antibiotics on the gut microbiota by supporting the growth of the beneficial bacterial groups, and consequently, alleviating the symptoms the patients experience during the antibiotic therapy [15,16].…”

Section: Introductionmentioning

confidence: 99%

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A Small In Vitro Fermentation Model for Screening the Gut Microbiota Effects of Different Fiber Preparations

Tsitko

Wiik-Miettinen

Mattila

et al. 2019

IJMS

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The development of prebiotic fibers requires fast high-throughput screening of their effects on the gut microbiota. We demonstrated the applicability of a mictotiter plate in the in vitro fermentation models for the screening of potentially-prebiotic dietary fibers. The effects of seven rye bran-, oat- and linseed-derived fiber preparations on the human fecal microbiota composition and short-chain fatty acid production were studied. The model was also used to study whether fibers can alleviate the harmful effects of amoxicillin-clavulanate on the microbiota. The antibiotic induced a shift in the bacterial community in the absence of fibers by decreasing the relative amounts of Bifidobacteriaceae, Bacteroidaceae, Prevotellaceae, Lachnospiraceae and Ruminococcaceae, and increasing proteobacterial Sutterilaceae levels from 1% to 11% of the total microbiota. The fermentation of rye bran, enzymatically treated rye bran, its insoluble fraction, soluble oat fiber and a mixture of rye fiber:soluble oat fiber:linseed resulted in a significant increase in butyrate production and a bifidogenic effect in the absence of the antibiotic. These fibers were also able to counteract the negative effects of the antibiotic and prevent the decrease in the relative amount of bifidobacteria. Insoluble and soluble rye bran fractions and soluble oat fiber were the best for controlling the level of proteobacteria at the level below 2%.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Small In Vitro Fermentation Model for Screening the Gut Microbiota Effects of Different Fiber Preparations

Tsitko

Wiik-Miettinen

Mattila

et al. 2019

IJMS

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“…RS2 has been shown to alter the abundance of at least some intestinal bacterial genera and species, including enrichment of Ruminococcus bromii , Bifidobacterium adolescentis , Faecalibacterium prausnitzii , and E. rectale and reductions in Oscillospira , Lachnospiraceae , and Blautia [ 163 ]. FOS are found in natural fruits and vegetables and can promote the growth of beneficial gut microbiota such as Bifidobacterium and Lactobacillus [ 164 , 165 ]. FOS are effective in maintaining the diversity and stability of the microbial community, alleviating neuronal apoptosis and the swelling of brain tissues, regulating the synthesis and secretion of neurotransmitters, and downregulating the expression of tau and Aβ1-42 in the brain of rats with AD-like symptoms [ 166 ].…”

Section: Potential Therapeutic Strategies For Ad Targeting the Microbmentioning

confidence: 99%

Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment

et al. 2020

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Understanding how gut flora influences gut-brain communications has been the subject of significant research over the past decade. The broadening of the term “microbiota-gut-brain axis” from “gut-brain axis” underscores a bidirectional communication system between the gut and the brain. The microbiota-gut-brain axis involves metabolic, endocrine, neural, and immune pathways which are crucial for the maintenance of brain homeostasis. Alterations in the composition of gut microbiota are associated with multiple neuropsychiatric disorders. Although a causal relationship between gut dysbiosis and neural dysfunction remains elusive, emerging evidence indicates that gut dysbiosis may promote amyloid-beta aggregation, neuroinflammation, oxidative stress, and insulin resistance in the pathogenesis of Alzheimer’s disease (AD). Illustration of the mechanisms underlying the regulation by gut microbiota may pave the way for developing novel therapeutic strategies for AD. In this narrative review, we provide an overview of gut microbiota and their dysregulation in the pathogenesis of AD. Novel insights into the modification of gut microbiota composition as a preventive or therapeutic approach for AD are highlighted.

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“…Furthermore, the consumption of XOS results in increased indigenous Bifidobacterium sp. levels in elderly gut microbiota (Miguez et al 2018).…”

Section: Cellulosementioning

confidence: 99%

Production of prebiotic xylooligosaccharide from aqueous ammonia‐pretreated rice straw by β‐xylosidase of Weissella cibaria

2019

J Appl Microbiol

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Aims This study focuses on the development of a new strategy xylooligosaccharide (XOS) production from aqueous ammonia‐pretreated rice straw (A‐PRS), followed by β‐xylosidase hydrolysis produced by the newly identified strain Weissella cibaria FB069. Methods and Results We report a higher efficiency of A‐PRS, including the removal of lignin and increase in cellulose and xylan content, compared to that of the alkali and stream explosion methods. Using the ammonia pretreatment method, rice straw was used to obtain 32·4% xylan. The crude xylanase from W. cibaria was used to hydrolyse A‐PRS over different hydrolysis times. The highest XOS yield (131 mg XOS per gram rice straw) was observed after 10 h. XOS produced from the PRS was tested on stimulation effect on Bifidobacterium and Lactobacillus. Conclusion The possibility of XOS production from PRS using β‐xylosidase with strong prebiotic properties. Significance and Impact of the Study We investigated the new strain for signification production of XOS. The two‐stage process here described could help to further explore the optimization conditions for prebiotic production. Additionally, the stimulation effect of XOS from alternative source has a promising prospect in functional food.

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Potential of Fructooligosaccharides and Xylooligosaccharides as Substrates To Counteract the Undesirable Effects of Several Antibiotics on Elder Fecal Microbiota: A First in Vitro Approach

Cited by 26 publications

References 54 publications

A Small In Vitro Fermentation Model for Screening the Gut Microbiota Effects of Different Fiber Preparations

A Small In Vitro Fermentation Model for Screening the Gut Microbiota Effects of Different Fiber Preparations

Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment

Production of prebiotic xylooligosaccharide from aqueous ammonia‐pretreated rice straw by β‐xylosidase of Weissella cibaria

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