Potential of Ethanolic Extract of Ficus Benghalensis on Open Wounds and Inflammation

Abstract

AbstractsThe present study deals with evaluation of antioxidant, wound healing and anti-inflammatory activity of ethanolic extract of Curcuma longa Linn rhizomes. The ethanolic extract prepared by maceration technique was subjected to screen for antioxidant activity using DPPH radical scavenging method and wound healing activity using incision, excision, histopathological and dead space wound model and the study was supported with evaluation of granuloma tissue to estimate hydroxyproline content and histopathological evaluation. The anti-inflammatory study was carried out by using carageenan induced rat paw odema method. The tested extract of different dilutions in range 200µg/ml to 1000 µg/ml shows activity in range of 9.34% to 18.55%. Significant increase in wound closure rate, skin breaking strength, granuloma breaking strength was observed. The hydroxyproline content was also increased with decrease in scar area. The initial healing action might be due to increased collagen deposition and better alignment, with the obtained results it can be concluded that Curcuma longa extract has significant wound healing activity and initial healing may be due to presence of some terpenoids and antimicrobial agents. The extract shows prominent anti-inflammatory activity as compared to that of standard (Ibuprofen gel). The extract shows good anti-inflammatory activity on carageenan induced rat paw odema method.

Isolation and Characterization of Anti-Inflammatory Compounds from Ficus microcarpa L.f. Stem Bark

“…The obtained results demonstrate the significant anti-inflammatory activity of F. microcarpa and its phenolic compounds in both COX inhibition and protein denaturation assays. These findings align with studies on other Ficus species, such as F. racemosa leaves and bark [ 34 , 35 , 36 ], F. religiosa leaves and bark [ 37 , 38 ], F. benghalensis bark [ 39 , 40 ], and F. carica [ 41 ]. The literature has documented that catechin can exert noteworthy anti-inflammatory properties by modulating the activation or deactivation of inflammation-related oxidative stress signaling pathways.…”

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“…The ethanolic extract of leaves of Ficus religiosa was evaluated for antioxidant (DPPH) activity. The tested extract of different dilutions in the range 200 µg/ml to 1000 µg/ml shows antioxidant activity in a range of 6.34% to 13.35% 48 . Root extracts showed significant antioxidant activity against carbon tetrachloride induced liver injury in rats 49 .…”

“…The high rate of wound contraction, decrease in the period for epithelialization, high skin breaking strength were observed in animals treated with 10% leaf extract ointment when compared to the control group of animals. It has been reported that tannins possess the ability to increase the collagen content, which is one of the factors for the promotion of wound healing 48,2 .…”

Evaluation of a Newly Formulated Anti-Inflammatory Ointment from Ficus religiosa Root Bark

“…Animals were given free access to water and were fasted for 24 hours before the experiment. 16 Edema was created by injecting 0.1 mL of 1% w/v carrageenan in saline into the rat's right hind leg plantar side an hour before each experiment. Utilizing the index finger, lightly brush the planting region of the chest paw 50 times before applying 0.2 g of ointment.…”