Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction

Kikuchi, Kiyoshi; Kikuchi, Kôichi; Uchikado, Hisaaki; Miyagi, Naohisa; Kuramoto, Terukazu; Miyagi, Tomoya; Morimoto, Yoko; Ito, Takashi; Tancharoen, Salunya; Miura, Naoki; Takenouchi, Kazunori; Oyama, Yoko; Shrestha, Binita; Matsuda, Fumiyo; Yoshida, Yasuhiko; Arimura, Shinihiro; Mera, Kentaro; Tada, Koichi; Yoshinaga, Narimasa; Maenosono, Ryuichi; Ohno, Yoshiko; Hashiguchi, Teruto; Maruyama, Ikuro; Shigemori, Minoru

doi:10.3892/etm.2011.281

Cited by 27 publications

(17 citation statements)

References 65 publications

(69 reference statements)

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“…Edaravone has been widely used in patients with AIS since April 2001 in Japan, because many clinical and experimental studies have demonstrated neurovascular protective effects [11–15]. Furthermore, edaravone has anti-apoptotic, anti-necrotic, and anti-inflammatory cytokine effects, as well as scavenging free radicals in cardiovascular diseases and stroke, showing protective effects in the heart, vessel, and brain in experimental studies [16–19]. Moreover, edaravone has preventive effects on myocardial injury following ischemia and reperfusion (I/R) in patients with acute myocardial infarction (AMI) [20].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease

Kikuchi

Tancharoen

Takeshige

et al. 2013

IJMS

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Edaravone was originally developed as a potent free radical scavenger, and has been widely used to treat acute ischemic stroke in Japan since 2001. Free radicals play an important role in the pathogenesis of a variety of diseases, such as cardiovascular diseases and stroke. Therefore, free radicals may be targets for therapeutic intervention in these diseases. Edaravone shows protective effects on ischemic insults and inflammation in the heart, vessel, and brain in experimental studies. As well as scavenging free radicals, edaravone has anti-apoptotic, anti-necrotic, and anti-cytokine effects in cardiovascular diseases and stroke. Edaravone has preventive effects on myocardial injury following ischemia and reperfusion in patients with acute myocardial infarction. Edaravone may represent a new therapeutic intervention for endothelial dysfunction in the setting of atherosclerosis, heart failure, diabetes, or hypertension, because these diseases result from oxidative stress and/or cytokine-induced apoptosis. This review evaluates the potential of edaravone for treatment of cardiovascular disease, and covers clinical and experimental studies conducted between 1984 and 2013. We propose that edaravone, which scavenges free radicals, may offer a novel option for treatment of cardiovascular diseases. However, additional clinical studies are necessary to verify the efficacy of edaravone.

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Section: Introductionmentioning

confidence: 99%

The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease

Kikuchi

Tancharoen

Takeshige

et al. 2013

IJMS

Self Cite

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“…There has been a report that edaravone was effective in neonatal cerebral ischemia [26] and epilepsy [27]. Edaravone has been studied in traumatic brain injury, spinal cord injury, neurodegenerative disease, and brain tumor [28–30]. Thus, edaravone is thought to have various effects on central nervous system disturbances.…”

Section: Discussionmentioning

confidence: 99%

Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model

Ikeda

Harada

Ohwatashi

et al. 2013

The Scientific World Journal

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Edaravone is a free radical scavenger that protects the adjacent cortex during cerebral infarction. We created a hemiparetic model of cerebral thrombosis from a photochemically induced infarction with the photosensitive dye, rose bengal, in rats. We examined the effects of edaravone on recovery in the model. A total of 36 adult Wistar rats were used. The right sensorimotor area was irradiated with green light with a wavelength of 533 nm (10 mm diameter), and the rose bengal was injected intravenously to create an infarction. The edaravone group was injected intraperitoneally with edaravone (3 mg/kg), and the control group was injected with saline. The recovery process of the hemiplegia was evaluated with the 7-step scale of Fenny. The infarcted areas were measured after fixation. The recovery of the paralysis in the edaravone-treated group was significantly earlier than that in the untreated group. Seven days later, both groups were mostly recovered and had scores of 7, and the infarction region was significantly smaller in the edaravone-treated group. Edaravone reduced the infarction area and promoted the functional recovery of hemiparesis from cerebral thrombosis in a rat model. These findings suggest that edaravone treatment would be effective in clinical patients recovering from cerebral infarction.

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“…Edaravone has shown protective effects on ischemic insults and inflammation in the heart, vessel, and brain in experimental studies [10]. In addition, edaravone has shown neuroprotective effects on amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) in animal models [11]. Based on these results we propose that edaravone may be potent in the treatment of neurodegenerative disorders associated with oxidative stress.…”

Section: Introductionmentioning

confidence: 95%

Edaravone injection ameliorates cognitive deficits in rat model of Alzheimer’s disease

Yang

Wang

et al. 2015

Neurol Sci

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Oxidative stress plays important role in the pathogenesis of Alzheimer's disease (AD). Edaravone is a potent free radical scavenger that exerts antioxidant effects. Therefore, in this study we aimed to investigate neuroprotective effects of edaravone for AD. Wistar rats were randomly divided into three groups (n = 15): control group, model group, and treatment group, which were injected with phosphate buffered saline, Aβ1-40, and Aβ1-40 together with 5 mg/kg edaravone, respectively, into the right hippocampal dentate gyrus. Spatial learning and memory of the rats were examined by Morris water maze test. 4-Hydroxynonenal (4-HNE) level in rat hippocampus was analyzed by immunohistochemistry. Acetylcholinesterase (AChE) and choline acetylase (ChAT) activities were assayed by commercial kits. We found that edaravone ameliorated spatial learning and memory deficits in the rats. 4-HNE level in the hippocampus as well as AChE and ChAT activities in the hippocampus was significantly lower in treatment group than in model group. In conclusion, edaravone may be developed as a novel agent for the treatment of AD for improving cholinergic system and protecting neurons from oxidative toxicity.

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Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction

Cited by 27 publications

References 65 publications

The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease

The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease

Effects of Edaravone, a Free Radical Scavenger, on Photochemically Induced Cerebral Infarction in a Rat Hemiplegic Model

Edaravone injection ameliorates cognitive deficits in rat model of Alzheimer’s disease

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