Potential of Early [
            <sup>18</sup>
            F]-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography for Identifying Hypoperfusion and Predicting Fate of Tissue in a Rat Embolic Stroke Model

Walberer, Maureen; Backes, Heiko; Rueger, Maria Adele; Neumaier, Bernd; Endepols, Heike; Hoehn, Mathias; Fink, Gereon R.; Schroeter, Michael; Graf, Rudolf

doi:10.1161/strokeaha.111.624551

Cited by 32 publications

(28 citation statements)

References 35 publications

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“…Using PET, an increased uptake of FDG in regions with mild reduction of CBF was also reported in rats 75 minutes after MCAO. 9 However, this hyper-uptake pattern no longer existed 3 hours after MCAO in another study. 10 Nasu et al 11 imaged patients with stroke 1 to 7 days after cerebral ischemia using FDG PET, and hyper-accumulation of FDG was observed around the depressed uptake core in 7 of 20 patients.…”

mentioning

confidence: 89%

Spatiotemporal Uptake Characteristics of [ ¹⁸ ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model

Yuan

Frank

Hong

et al. 2013

Stroke

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Background and Purpose Alterations of cerebral glucose metabolism are well anticipated during cerebral ischemia. However, detailed spatiotemporal characteristics of disturbed cerebral glucose metabolism during acute ischemia remain largely elusive. This study aims to delineate spatiotemporal distributions of [18]F-2-fluoro-2-deoxy-D-glucose (FDG) uptake using positron emission tomography imaging, particularly at the peri-ischemic zone, and its correlation with tissue outcome. Methods The intraluminal suture middle cerebral artery occlusion model was used to induce focal cerebral ischemia in rats (n=48). All animals underwent sequential MRI and FDG positron emission tomography imaging at different times (30–150 minutes) after middle cerebral artery occlusion. MR and positron emission tomography images were coregistered. FDG uptake in the peri-ischemic zone was assessed in relation to middle cerebral artery occlusion duration, cerebral blood flow, apparent diffusion coefficient, and 24-hour T2 lesions. Results Elevated FDG uptake was consistently observed at the peri-ischemic zone surrounding the presumed ischemic core with low FDG uptake. Both the spatial volume and the uptake level of the hyper-uptake region were inversely correlated with the duration of middle cerebral artery occlusion. The hyper-uptake regions exhibited a mild reduction of cerebral blood flow (28.2±3.2%) and apparent diffusion coefficient (9.1±1.4%) when compared with that in the contralateral hemisphere. Colocalization analysis revealed that, with reperfusion, an average of 12.1±1.7% of the hyper-uptake volume was recruited into final infarction. Conclusions Elevated FDG uptake at the peri-ischemic zone is consistently observed during acute cerebral ischemia. The region with elevated FDG uptake likely reflects viable tissues that can be salvaged with reperfusion. Therefore, acute FDG positron emission tomography imaging might hold promise in the management of patients with acute stroke.

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confidence: 89%

Spatiotemporal Uptake Characteristics of [ ¹⁸ ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model

Yuan

Frank

Hong

et al. 2013

Stroke

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“…In a rat model of contusion spinal cord injury (SCI), reductions in FDG uptake activity at the injury site were measured when compared to uninjured cord (Nandoe Tewarie et al, 2010). Rat models of ischemia have used FDG-PET to detect metabolic variations as markers of predicting tissue fate or recoverability (Fu et al, 2009; Walberer et al, 2012) and have shown FDG-PET to be more sensitive to metabolic alterations in the ischemic core at earlier time points post-injury (Sobrado et al, 2011). FDG-PET has also been useful for tracking novel treatment outcomes of ischemia, as demonstrated by recent work with transplantation of bone marrow stromal cells for improvement in cerebral glucose metabolism (Miyamoto et al, 2013).…”

Section: Fdg-pet and Tbimentioning

confidence: 99%

FDG-PET imaging in mild traumatic brain injury: a critical review

Byrnes

Wilson

Brabazon

et al. 2014

Front. Neuroenergetics

137

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Traumatic brain injury (TBI) affects an estimated 1.7 million people in the United States and is a contributing factor to one third of all injury related deaths annually. According to the CDC, approximately 75% of all reported TBIs are concussions or considered mild in form, although the number of unreported mild TBIs (mTBI) and patients not seeking medical attention is unknown. Currently, classification of mTBI or concussion is a clinical assessment since diagnostic imaging is typically inconclusive due to subtle, obscure, or absent changes in anatomical or physiological parameters measured using standard magnetic resonance (MR) or computed tomography (CT) imaging protocols. Molecular imaging techniques that examine functional processes within the brain, such as measurement of glucose uptake and metabolism using [18F]fluorodeoxyglucose and positron emission tomography (FDG-PET), have the ability to detect changes after mTBI. Recent technological improvements in the resolution of PET systems, the integration of PET with magnetic resonance imaging (MRI), and the availability of normal healthy human databases and commercial image analysis software contribute to the growing use of molecular imaging in basic science research and advances in clinical imaging. This review will discuss the technological considerations and limitations of FDG-PET, including differentiation between glucose uptake and glucose metabolism and the significance of these measurements. In addition, the current state of FDG-PET imaging in assessing mTBI in clinical and preclinical research will be considered. Finally, this review will provide insight into potential critical data elements and recommended standardization to improve the application of FDG-PET to mTBI research and clinical practice.

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“…Two recent studies evaluated 18 F-FDG metabolism 75 minutes [54] and 3 hours [55] after MCAO using an ischemic stroke model, respectively. Sobrado et al carried out a longitudinal evaluation of 18 F-FDG metabolism and infarct size [55].…”

Section: Evaluation Of Glucose Metabolism In Ischemic Strokementioning

confidence: 99%

The Potential Roles of¹⁸F-FDG-PET in Management of Acute Stroke Patients

Bunevičius

Yuan

Lin

2013

BioMed Research International

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Extensive efforts have recently been devoted to developing noninvasive imaging tools capable of delineating brain tissue viability (penumbra) during acute ischemic stroke. These efforts could have profound clinical implications for identifying patients who may benefit from tPA beyond the currently approved therapeutic time window and/or patients undergoing neuroendovascular treatments. To date, the DWI/PWI MRI and perfusion CT have received the most attention for identifying ischemic penumbra. However, their routine use in clinical settings remains limited. Preclinical and clinical PET studies with [18F]-fluoro-2-deoxy-D-glucose (18F-FDG) have consistently revealed a decreased 18F-FDG uptake in regions of presumed ischemic core. More importantly, an elevated 18F-FDG uptake in the peri-ischemic regions has been reported, potentially reflecting viable tissues. To this end, this paper provides a comprehensive review of the literature on the utilization of 14C-2-DG and 18F-FDG-PET in experimental as well as human stroke studies. Possible cellular mechanisms and physiological underpinnings attributed to the reported temporal and spatial uptake patterns of 18F-FDG are addressed. Given the wide availability of 18F-FDG in routine clinical settings, 18F-FDG PET may serve as an alternative, non-invasive tool to MRI and CT for the management of acute stroke patients.

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Potential of Early [ ¹⁸ F]-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography for Identifying Hypoperfusion and Predicting Fate of Tissue in a Rat Embolic Stroke Model

Cited by 32 publications

References 35 publications

Spatiotemporal Uptake Characteristics of [ ¹⁸ ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model

Spatiotemporal Uptake Characteristics of [ ¹⁸ ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model

FDG-PET imaging in mild traumatic brain injury: a critical review

The Potential Roles of¹⁸F-FDG-PET in Management of Acute Stroke Patients

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Potential of Early [ 18 F]-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography for Identifying Hypoperfusion and Predicting Fate of Tissue in a Rat Embolic Stroke Model

Cited by 32 publications

References 35 publications

Spatiotemporal Uptake Characteristics of [ 18 ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model

Spatiotemporal Uptake Characteristics of [ 18 ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model

FDG-PET imaging in mild traumatic brain injury: a critical review

The Potential Roles of18F-FDG-PET in Management of Acute Stroke Patients

Contact Info

Product

Resources

About

Potential of Early [ ¹⁸ F]-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography for Identifying Hypoperfusion and Predicting Fate of Tissue in a Rat Embolic Stroke Model

Spatiotemporal Uptake Characteristics of [ ¹⁸ ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model

Spatiotemporal Uptake Characteristics of [ ¹⁸ ]F-2-Fluoro-2-Deoxy- d -Glucose in a Rat Middle Cerebral Artery Occlusion Model

The Potential Roles of¹⁸F-FDG-PET in Management of Acute Stroke Patients