Potential of DIVA Vaccines for Fish

Monaghan, Sean J.; Thompson, Kim D.; Smith, Patrick; Adams, Alexandra

doi:10.1007/978-3-0348-0980-1_7

Cited by 3 publications

(2 citation statements)

References 186 publications

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“…Prophylactic treatments, for example aiming at strengthening or preparing the immune response such as vaccination, are always preferable to therapeutic ones [ 135 – 138 ]. However, preventative therapies are not always possible or practical, therapies based on small nucleotide based medicine such as siRNA or CRISPR/Cas are on the horizon.…”

Section: Discussionmentioning

confidence: 99%

A new age in AquaMedicine: unconventional approach in studying aquatic diseases

et al. 2018

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BackgroundMarine and aquaculture industries are important sectors of the food production and global trade. Unfortunately, the fish food industry is challenged with a plethora of infectious pathogens. The freshwater and marine fish communities are rapidly incorporating novel and most up to date techniques for detection, characterization and treatment strategies. Rapid detection of infectious diseases is important in preventing large disease outbreaks.Main textOne hundred forty-six articles including reviews papers were analyzed and their conclusions evaluated in the present paper. This allowed us to describe the most recent development research regarding the control of diseases in the aquatic environment as well as promising avenues that may result in beneficial developments. For the characterization of diseases, traditional sequencing and histological based methods have been augmented with transcriptional and proteomic studies. Recent studies have demonstrated that transcriptional based approaches using qPCR are often synergistic to expression based studies that rely on proteomic-based techniques to better understand pathogen-host interactions. Preventative therapies that rely on prophylactics such as vaccination with protein antigens or attenuated viruses are not always feasible and therefore, the development of therapies based on small nucleotide based medicine is on the horizon. Of those, RNAi or CRISPR/Cas- based therapies show great promise in combating various types of diseases caused by viral and parasitic agents that effect aquatic and fish medicine.ConclusionsIn our modern times, when the marine industry has become so vital for feed and economic stability, even the most extreme alternative treatment strategies such as the use of small molecules or even the use of disease to control invasive species populations should be considered.

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Section: Discussionmentioning

confidence: 99%

A new age in AquaMedicine: unconventional approach in studying aquatic diseases

et al. 2018

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“…The biosafety as well as effectuality of these vaccines depend on the conditions of cultivation, such as temperature range and type of media (Toranzo et al, 2009). Some of the diseases that can be prevented by using inactivated vaccines include V. salmonicida, A. salmonicida, and infectious hematopoietic necrosis (Monaghan et al, 2016). In aquaculture, mostly inactivated vaccines are used.…”

Section: Inactivated/killed Vaccinesmentioning

confidence: 99%

Effects of Probiotics and Current Scenario of Fish Vaccination

al.¹

2022

Egypt. J. of Aquatic Biolo. and Fish.

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New vaccination approach using formalin-killed Streptococcus pyogenes vaccine on the liver of Oreochromis niloticus fingerlings

Nasr-Eldahan,

Attia Shreadah,

Maher

et al. 2024

Sci Rep

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Newly synthesized vaccines prepared from formalin-killed bacteria Streptococcus pyogenes were investigated in the current study to evaluate the effectiveness of the newly synthesized vaccine as well as their safety by injected intraperitoneal. The study involved several steps 1st step is the preparation of the vaccine followed by the 2nd step: Evaluate the effectiveness and vaccine safety against pathogenic S. pyogenes through 4 different groups including control (Group I). Group II (Bacterial, infected group), Group III (Vaccine), and the Last group was the challenged group after the vaccination (Vacc + Bac). Different Immunological and biochemical parameters were measured in addition to hematological and histopathological examinations. For example, oxidative/antioxidants, inflammatory biomarkers, fragmentation and cell damage, and finally the histopathological study. The current study showed an increase in all oxidative, inflammatory, and cell damage (DNA fragmentation assays), additionally markedly elevation in histopathological cell damage in the infected group (Group II) compared with the control group. The vaccine and challenged after vaccination group (vaccine + Bacteria), showed great improvement in oxidative biomarkers (LPO) and an increase in antioxidants biomarkers (GSH, SOD, GST, DPPH, ABTS, GR and GPx), Also the inflammation and histopathological examination. The newly synthesized vaccine improved the resistance of Oreochromis niloticus and can be used as a preventive therapy agent for pathogenic bacteria S. pyogenes.

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Potential of DIVA Vaccines for Fish

Cited by 3 publications

References 186 publications

A new age in AquaMedicine: unconventional approach in studying aquatic diseases

A new age in AquaMedicine: unconventional approach in studying aquatic diseases

Effects of Probiotics and Current Scenario of Fish Vaccination

New vaccination approach using formalin-killed Streptococcus pyogenes vaccine on the liver of Oreochromis niloticus fingerlings

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