Potential of desorption electrospray ionization and paper spray ionization with high-resolution mass spectrometry for the screening of sports doping agents in urine

Bressan, Claudia; Seró, Raquel; Alechaga, Élida; Monfort, Núria; Moyano, Encarnación; Ventura, Rosa

doi:10.1039/d2ay01687g

Cited by 4 publications

(4 citation statements)

References 48 publications

(65 reference statements)

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“…44 There is recent evidence of interest in the use of AIMS in antidoping, with ASAP being utilized for the analysis of anabolic steroids 45 and both DESI and PS-MS for the rapid detection of stimulants and diuretics in urine. 46 The development of ambient ionization techniques for the analysis of explosives also constitutes a notable proportion of applications in forensic science. The rapid detection and identification of explosives are of crucial importance to national security, and the development of techniques that could feasibly be installed in airports and used on-site at incident scenes are of particular interest.…”

Section: Kim Et Al Used Sfpesi For the Rapid Detection Of Cocaine Met...mentioning

confidence: 99%

“…Numerous other AIMS techniques have proven capable in the analysis of controlled substances, including coated blade spray (CBS), 42 PS‐MS, 43 and thermal desorption‐assisted DBD 44 . There is recent evidence of interest in the use of AIMS in anti‐doping, with ASAP being utilized for the analysis of anabolic steroids 45 and both DESI and PS‐MS for the rapid detection of stimulants and diuretics in urine 46 …”

Section: Applications Of Aimsmentioning

confidence: 99%

“… 44 There is recent evidence of interest in the use of AIMS in anti‐doping, with ASAP being utilized for the analysis of anabolic steroids 45 and both DESI and PS‐MS for the rapid detection of stimulants and diuretics in urine. 46 …”

Section: Applications Of Aimsmentioning

confidence: 99%

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Applications of ambient ionization mass spectrometry in 2022: An annual review

Rankin‐Turner

Sears

Heaney

2023

Analytical Science Advances

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The development of ambient ionization mass spectrometry (AIMS) has transformed analytical science, providing the means of performing rapid analysis of samples in their native state, both in and out of the laboratory. The capacity to eliminate sample preparation and pre‐MS separation techniques, leading to true real‐time analysis, has led to AIMS naturally gaining a broad interest across the scientific community. Since the introduction of the first AIMS techniques in the mid‐2000s, the field has exploded with dozens of novel ion sources, an array of intriguing applications, and an evident growing interest across diverse areas of study. As the field continues to surge forward each year, ambient ionization techniques are increasingly becoming commonplace in laboratories around the world. This annual review provides an overview of AIMS techniques and applications throughout 2022, with a specific focus on some of the major fields of research, including forensic science, disease diagnostics, pharmaceuticals and food sciences. New techniques and methods are introduced, demonstrating the unwavering drive of the analytical community to further advance this exciting field and push the boundaries of what analytical chemistry can achieve.

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Section: Kim Et Al Used Sfpesi For the Rapid Detection Of Cocaine Met...mentioning

confidence: 99%

Section: Applications Of Aimsmentioning

confidence: 99%

See 1 more Smart Citation

Applications of ambient ionization mass spectrometry in 2022: An annual review

Rankin‐Turner

Sears

Heaney

2023

Analytical Science Advances

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“…Assessing the opposite approach, that is, omitting (largely) sample preparation and chromatography and employing desorption electrospray as well as paperspray ionization HRAM MS, was conducted by Bressan et al 97 Urine was analyzed as raw matrix or subjected to SPE, with the urine or the extracts deposited on different supports (polytetrafluoroethylene, C‐18‐ and cellulose‐based chromatographic paper). The dried samples were then either desorbed with methanol/water (80:20, v / v ) or sprayed with acetonitrile/water (85:15, v / v ) into a Q/Orbitrap MS, operated in positive and negative ionization mode.…”

Section: Diuretics and Masking Agents Stimulants And Narcoticsmentioning

confidence: 99%

Annual banned‐substance review 16^th edition—Analytical approaches in human sports drug testing 2022/2023

Thevis,

Kuuranne,

Geyer

2023

Drug Testing and Analysis

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In this 16th edition of the annual banned‐substance review on analytical approaches in human sports drug testing, literature on recent developments in this particular section of global anti‐doping efforts that was published between October 2022 and September 2023 is summarized and discussed. Most recent additions to the continuously growing portfolio of doping control analytical approaches and investigations into analytical challenges in the context of adverse analytical findings are presented, taking into account existing as well as emerging challenges in anti‐doping, with specific focus on substances and methods of doping recognized in the World Anti‐Doping Agency's 2023 Prohibited List. As in previous years, focus is put particularly on new or enhanced analytical options in human doping controls, appreciating the exigence and core mission of anti‐doping and, equally, the conflict arising from the opposingly trending extent of the athlete's exposome and the sensitivity of instruments nowadays commonly available in anti‐doping laboratories.

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Ambient ionisation mass spectrometry for drug and toxin analysis: A review of the recent literature

Henderson,

Heaney,

Rankin‐Turner

2024

Drug Testing and Analysis

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Ambient ionisation mass spectrometry (AIMS) is a form of mass spectrometry whereby analyte ionisation occurs outside of a vacuum source under ambient conditions. This enables the direct analysis of samples in their native state, with little or no sample preparation and without chromatographic separation. The removal of these steps facilitates a much faster analytical process, enabling the direct analysis of samples within minutes if not seconds. Consequently, AIMS has gained rapid popularity across a diverse range of applications, in particular the analysis of drugs and toxins. Numerous fields rely upon mass spectrometry for the detection and identification of drugs, including clinical diagnostics, forensic chemistry, and food safety. However, all of these fields are hindered by the time‐consuming and laboratory‐confined nature of traditional techniques. As such, the potential for AIMS to resolve these challenges has resulted in a growing interest in ambient ionisation for drug and toxin analysis. Since the early 2000s, forensic science, diagnostic testing, anti‐doping, pharmaceuticals, environmental analysis and food safety have all seen a marked increase in AIMS applications, foreshadowing a new future for drug testing. In this review, some of the most promising AIMS techniques for drug analysis will be discussed, alongside different applications of AIMS published over a 5‐year period, to provide a summary of the recent research activity for ambient ionisation for drug and toxin analysis.

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Potential of desorption electrospray ionization and paper spray ionization with high-resolution mass spectrometry for the screening of sports doping agents in urine

Abstract: In this work, desorption electrospray ionization and paper spray ionization both with high-resolution mass spectrometry (DESI-HRMS, PSI-HRMS) were explored for the fast and direct analysis of stimulants and diuretics in...

Cited by 4 publications

References 48 publications

Applications of ambient ionization mass spectrometry in 2022: An annual review

Applications of ambient ionization mass spectrometry in 2022: An annual review

Annual banned‐substance review 16^th edition—Analytical approaches in human sports drug testing 2022/2023

Ambient ionisation mass spectrometry for drug and toxin analysis: A review of the recent literature

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Potential of desorption electrospray ionization and paper spray ionization with high-resolution mass spectrometry for the screening of sports doping agents in urine

Abstract: In this work, desorption electrospray ionization and paper spray ionization both with high-resolution mass spectrometry (DESI-HRMS, PSI-HRMS) were explored for the fast and direct analysis of stimulants and diuretics in...

Cited by 4 publications

References 48 publications

Applications of ambient ionization mass spectrometry in 2022: An annual review

Applications of ambient ionization mass spectrometry in 2022: An annual review

Annual banned‐substance review 16th edition—Analytical approaches in human sports drug testing 2022/2023

Ambient ionisation mass spectrometry for drug and toxin analysis: A review of the recent literature

Contact Info

Product

Resources

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Annual banned‐substance review 16^th edition—Analytical approaches in human sports drug testing 2022/2023