Potential of curcumin-mediated photodynamic inactivation to reduce oral colonization

Santezi, Carolina; Tanomaru, Juliane Maria Guerreiro; Bagnato, Vanderlei Salvador; Júnior, Osmir B. Oliveira; Dovigo, Lívia Nordi

doi:10.1016/j.pdpdt.2016.04.006

Cited by 31 publications

(14 citation statements)

References 59 publications

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“…Dental applications of curcumin have also been investigated during the last decade [ 26 ]. In antimicrobial photodynamic therapy, curcumin has been extensively investigated as a photosensitizer in light-emitting diode (LED) activation techniques for periodontal and orthodontic cases [ 27 , 28 , 29 , 30 , 31 ]. Moreover, various formulations of curcumin have exhibited potential as adjunct therapies for professional scaling and root planning for periodontal disease treatment or general oral hygiene and mouthwash agents [ 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies

Xidaki¹,

Agrafioti

Diomatari

et al. 2018

Materials

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The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA—87% TCP and 41% HA—59% TCP. All samples were treated with curcumin solutions, and the degree of curcumin loading and release was found to be proportional to the TCP content of the ceramic. No further cytotoxicity was observed upon MG-63 treatment with the curcumin-loaded ceramics. Finally, the alkaline phosphatase activity of the cells was found to increase with increasing content of TCP, which provides an encouraging proof of concept for the use of curcumin-loaded synthetic biomaterials in bone remodeling.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies

Xidaki¹,

Agrafioti

Diomatari

et al. 2018

Materials

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“…Santezi et al [16] showed the antimicrobial inativation of 2.54 log 10 of salivary pathogens using a water-soluble mixture of curcuminoids (3 g/L) and 9.0 J/cm 2 by PI, however presented similar effects using the curcumin without light. CF can promote adherence on oral mucosa and improve the photobleaching during PDT.…”

Section: Antimicrobial Photodynamic Inativationmentioning

confidence: 99%

Antimicrobial Efficacy of Curcumin Formulations by Photodynamic Therapy

Blanco¹,

Inada²,

Carbinatto³

et al. 2017

JPP

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URTI (upper respiratory tract infections) are caused by acute, chronic or recurrent infections including pharyngitis and tonsillitis. The etiologic agents involved are bacteria, virus, and fungi. The standard treatment for bacterial infections is the use of antibiotics. The antibiotic resistance, side effects of drugs and URTI complications indicate the importance of new therapies. PDT (photodynamic therapy) is a treatment option with a fast onset of action, low side effects, and easy administration of PS (photosensitizer) based on this study. The main aim of this study was to develop a new modality for the treatment of infectious pharyngotonsillitis by photodynamic therapy. In addition, this study aims to evaluate components of the therapy as the PS, curcumin, in two formulations and irradiation conditions in the effectiveness of treatment. The procedure consists of two steps: oral administration of CFs (curcumin formulations) containing a PS and illumination (450 nm and 0-60 J/cm 2 ). Bacterial isolates were obtained from patients in a routine clinical pratice. The new methodology has been developed from the principle of PI (photodynamic inactivation). The strain identification number of colony forming units determined the efficacy of PI using each component, lighting and PS. The use of curcumin formulations in PI presented microbial reduction of 5 log .

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“…3.9. The problem of the solubility and the stability CUR has showed higher in vitro efficacy against oral microorganisms [6][7][8][9][10][11][12][13][14][15]24,25,[40][41][42][43][44][45][46][47][48][49][50]. However, apart from its efficacy, CUR is a hydrophobic polyphenol with no aqueous solubility and poor bioavailability.…”

Section: Cancer Studiesmentioning

confidence: 99%

“…Additionally, other studies have reported that CUR acts as a potential anti-neuroinflammatory agent benefiting patients diagnosed with Alzheimer, Multiple Sclerosis and Dementia caused by HIV [37]. CUR has also shown great potential as a PS because of its ability to absorb blue light [8,10,25,[38][39][40][41][42]. Recently, a growing body of evidence shows the promising applications of CUR against different diseases, including some of the main oral pathologies [8,13,24,25].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-mediated Photodynamic Therapy for the treatment of oral infections—A review

Santezi

Reina

Dovigo

2018

Photodiagnosis and Photodynamic Therapy

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103

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Potential of curcumin-mediated photodynamic inactivation to reduce oral colonization

Abstract: The results show that PDI with CRM at the studied concentrations is as effective for oral decontamination in clinical dental care conditions as the CLX at 0.12% for 1min.

Cited by 31 publications

References 59 publications

Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies

Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies

Antimicrobial Efficacy of Curcumin Formulations by Photodynamic Therapy

Curcumin-mediated Photodynamic Therapy for the treatment of oral infections—A review

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