Potential of combination of DCE-MRI and DWI with serum CA125 and CA199 in evaluating effectiveness of neoadjuvant chemotherapy in breast cancer

Zhang, Jun; Huang, Yongbo; Chen, Jianghui; Wang, Xia; Ma, Hongyu

doi:10.1186/s12957-021-02398-w

“…In recent years, the incidence of ovarian cancer has shown a gradually increasing trend [ 2 ]. Due to the lack of early symptoms of ovarian cancer and the lack of early screening and diagnosis, the survival rate of patients has been less than 30% [ 3 ]. However, if detected at early stage and given standard surgery and adjuvant therapy, the 5-year survival rate of ovarian cancer can be as high as 90% [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

A Clinical Diagnostic Value Analysis of Serum CA125, CA199, and HE4 in Women with Early Ovarian Cancer: Systematic Review and Meta-Analysis

Qing

¹

,

Liu

²

,

Mao

³

2022

Computational and Mathematical Methods in Medicine

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Objective. To evaluate the value of combined detection of serum CA125, CA199, and HE4 in the diagnosis of ovarian cancer. Methods. Relevant articles retrieved from PubMed, Elsevier Science, Springer, China National Knowledge Infrastructure (CNKI), Wanfang, and VIP databases were screened strictly according to inclusion and exclusion criteria. Included literature published from January 2005 to December 2021. (2) Serum HE4, CA125, CA199, and their combination for ovarian cancer diagnostic tests were studied, and healthy subjects or patients with the benign disease were taken as a control group. (3) Pathological tissue diagnosis as the gold standard. (4) Complete original data can be obtained. (5) The sample size was ≥20. (6) Language is limited to Chinese and English. Data features and QUADAS table were extracted from the included literature, and QUADAS evaluation tool detail table was used for the included study. Conduct quality evaluation. Statistical analysis was carried out using meta-disc software version 1.4. Appropriate effect model was selected to merge the effect size, and the forest maps of merge sensitivity, merge specificity, and merge likelihood ratio were obtained. Results. The results of meta-analysis showed that there was a statistical difference in diagnostic specificity analysis of CA125 ( OR = 1.91 , 95% CI (1.58, 2.32), P < 0.00001 , I 2 = 67 % , Z = 6.58 ); diagnostic sensitivity analysis of CA125 ( OR = 2.50 , 95% CI (1.73, 3.62), P < 0.00001 , I 2 = 0 % , Z = 4.90 ); diagnostic specificity analysis of CA199 ( OR = 1.98 , 95% CI (1.60, 2.44), P < 0.00001 , I 2 = 89 % , Z = 6.35 ); diagnostic sensitivity analysis of CA199 ( OR = 1.92 , 95% CI (1.46, 2.52), P < 0.00001 , I 2 = 73 % , Z = 4.70 ); diagnostic specificity analysis of HE4 ( OR = 2.08 , 95% CI (1.65, 2.63), P < 0.00001 , I 2 = 73 % , Z = 6.19 ); diagnostic sensitivity analysis of HE4 ( OR = 2.37 , 95% CI (1.87, 3.00), P < 0.00001 , I 2 = 83 % , Z = 7.19 ). Conclusion. In the clinical assisted diagnosis of ovarian cancer, combined detection of CA125, CA199, and HE4 has the stronger discriminant ability and higher accuracy than single detection of CA125, which can improve the diagnostic efficiency.

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“…MR difusion-weighted imaging is a noninvasive functional examination method that can refect the difusion of water molecules in tissues. Since the difusion of water molecules is afected by the microstructure of cells, it can be used in disease diagnosis and therapeutic efcacy monitoring [15]. MR difusion-weighted imaging and changes in the ADC value can be used to evaluate the dynamic evaluation of the treatment efect of malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Diffusion-Weighted Imaging to Evaluate the Clinical Efficacy of CalliSpheres Drug-Loaded Microspheres in the Treatment of Advanced Bladder Cancer

Yang

¹

,

Chen

²

2023

Concepts in Magnetic Resonance Part A

1

0

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The MR diffusion-weighted imaging technique was used to evaluate the efficacy and safety of CalliSpheres drug-loaded microspheres for transarterial chemoembolization in the treatment of advanced bladder cancer. 35 patients with advanced bladder cancer were treated with CalliSpheres DLMS for transarterial chemoembolization. Imaging techniques such as magnetic resonance (MR) diffusion-weighted imaging were used to evaluate the therapeutic effect. The changes in serum tumor markers, immune function indexes, and oxidative stress indexes in patients before and after treatment were compared, and the quality of life of patients and the incidence of adverse reactions during follow-up were also evaluated. The results showed that the overall response rate (ORR) was 74.29% and that the disease control rate (DCR) was 97.14%. Compared with that before treatment, the ADC value of the tumor in patients with advanced bladder cancer detected by MR diffusion-weighted imaging technology was significantly increased after treatment and the maximum tumor diameter was significantly decreased P < 0.05 . Compared with those before treatment, the levels of serum tumor markers (CA199, CA724, and CA125) in advanced bladder cancer patients after treatment decreased P < 0.05 . The levels of T-lymphocyte subsets (CD3+ and CD4+) decreased, and CD8+ levels increased P < 0.05 . The levels of superoxide dismutase decreased P > 0.05 . At the same time, the subscale evaluation of function, symptoms, quality of life, adverse reactions, and economics of patients with advanced bladder cancer on the QLQ-C30 scale improved after treatment, and the incidence rate and recurrence rate during the follow-up period were 8.57% and 11.43%, respectively. It showed that CalliSpheres DLMS had a good clinical effect and high safety in the treatment of advanced bladder cancer and was a safe and feasible treatment method. The use of MR diffusion-weighted imaging technology could achieve quantitative evaluation of clinical efficacy of advanced bladder cancer.

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“…[2] <30% of patients survive because there are no early signs of OC or early screening or diagnosis. [26] Given the low prognosis of this cancer, it is necessary to improve the survival rates of patients by using methods to accurately predict the risk factors that affect the severity of cancer and early diagnosis. CA125 was first described in the early 1980s.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of CA125, HE4, and systemic immune-inflammation index in the preoperative investigation of ovarian masses

Song,

Qi,

Zhao

et al. 2023

Medicine

1

0

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This study aimed to ascertain the diagnostic accuracy of CA125, HE4, systemic immune-inflammation index (SII), fibrinogen-to-albumin ratio (FAR), prognostic nutritional index (PNI), and their combination for ovarian cancer (OC) to discover an optimal combined diagnostic index for early diagnosis of OC. A thorough investigation was conducted to ascertain the correlation between these markers and the pathological characteristics of OC, thereby providing a foundation for early identification and treatment of this disorder. One hundred seventy patients with documented OC and benign ovarian tumors (BOTs) treated at Hebei General Hospital between January 2019 and December 2022 were included in this retrospective study. Data analysis was conducted using IBM SPSS Statistics version V26.0, MedCalc Statistical Software version 19.4.0, and the R Environment for Statistical Computing software (R Foundation for Statistical Computing). Isolated CA125 showed the best application value for differentiating benign ovarian tumors from OC when the defined variables were compared separately. The combination of CA125, HE4, FAR, SII, and PNI displayed a greater area under the operating characteristic curve curve than any one of them or other combinations of the 5 variables. Compared to CA125 alone, the combination of CA125, HE4, FAR, SII, and PNI showed a slight gain in sensitivity (83.91%), negative predictive value (83.91%), accuracy (85.88%), and a decrease in negative likelihood ratio (0.180%). Higher preoperative CA125, HE4, SII, and FAR levels, and lower PNI levels predicted a higher probability of advanced OC progression and lymph node metastasis. FAR has better application value than other inflammation-related markers (PNI and SII). This study suggests that preoperative serum SII, PNI, and FAR may be clinically valuable markers in patients with OC. FAR has better application value than other inflammation-related markers (PNI and SII). As we delve deeper into the inflammatory mechanisms associated with tumors, we may discover more effective combinations of tumor and inflammatory biomarkers.

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Potential of combination of DCE-MRI and DWI with serum CA125 and CA199 in evaluating effectiveness of neoadjuvant chemotherapy in breast cancer

Cited by 12 publications

References 22 publications

A Clinical Diagnostic Value Analysis of Serum CA125, CA199, and HE4 in Women with Early Ovarian Cancer: Systematic Review and Meta-Analysis

A Clinical Diagnostic Value Analysis of Serum CA125, CA199, and HE4 in Women with Early Ovarian Cancer: Systematic Review and Meta-Analysis

Magnetic Resonance Diffusion-Weighted Imaging to Evaluate the Clinical Efficacy of CalliSpheres Drug-Loaded Microspheres in the Treatment of Advanced Bladder Cancer

Diagnostic value of CA125, HE4, and systemic immune-inflammation index in the preoperative investigation of ovarian masses

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