Potential of circulating <scp>lncRNA CASC2</scp> as a biomarker in reflecting the inflammatory cytokines, multi‐organ dysfunction, disease severity, and mortality in sepsis patients

Wang, Rui; Zhao, Jinglin; Wei, Qi; Wang, Hao; Zhao, Chunjiang; Hu, Changwei; Han, Yu; Zhi, Hui; Yang, Long; Dai, Qingchun; Liu, Cuicui

doi:10.1002/jcla.24569

Cited by 15 publications

(10 citation statements)

References 21 publications

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“…Some may roughly reflect the magnitude of the organ pathology—for example, liver injury (increasing transaminases levels), liver dysfunction (e.g., modestly increased bilirubin levels), liver failure (high bilirubin, profound coagulopathy), but there are, admittedly, many confounders. Human studies have demonstrated alterations in levels of numerous biomarkers in sepsis, and their correlation with organ failure and mortality, including markers of endothelial activation and injury, long noncoding RNAs, cancer protein biomarkers, and brain natriuretic peptide (64–68). Markers of leukocyte activation and function also associate with sepsis outcomes (67, 69–72).…”

Section: Resultsmentioning

confidence: 99%

Surviving Sepsis Campaign Research Priorities 2023

De Backer,

Deutschman,

Hellman

et al. 2024

Critical Care Medicine

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OBJECTIVES: To identify research priorities in the management, epidemiology, outcome, and pathophysiology of sepsis and septic shock. DESIGN: Shortly after publication of the most recent Surviving Sepsis Campaign Guidelines, the Surviving Sepsis Research Committee, a multiprofessional group of 16 international experts representing the European Society of Intensive Care Medicine and the Society of Critical Care Medicine, convened virtually and iteratively developed the article and recommendations, which represents an update from the 2018 Surviving Sepsis Campaign Research Priorities. METHODS: Each task force member submitted five research questions on any sepsis-related subject. Committee members then independently ranked their top three priorities from the list generated. The highest rated clinical and basic science questions were developed into the current article. RESULTS: A total of 81 questions were submitted. After merging similar questions, there were 34 clinical and ten basic science research questions submitted for voting. The five top clinical priorities were as follows: 1) what is the best strategy for screening and identification of patients with sepsis, and can predictive modeling assist in real-time recognition of sepsis? 2) what causes organ injury and dysfunction in sepsis, how should it be defined, and how can it be detected? 3) how should fluid resuscitation be individualized initially and beyond? 4) what is the best vasopressor approach for treating the different phases of septic shock? and 5) can a personalized/precision medicine approach identify optimal therapies to improve patient outcomes? The five top basic science priorities were as follows: 1) How can we improve animal models so that they more closely resemble sepsis in humans? 2) What outcome variables maximize correlations between human sepsis and animal models and are therefore most appropriate to use in both? 3) How does sepsis affect the brain, and how do sepsis-induced brain alterations contribute to organ dysfunction? How does sepsis affect interactions between neural, endocrine, and immune systems? 4) How does the microbiome affect sepsis pathobiology? 5) How do genetics and epigenetics influence the development of sepsis, the course of sepsis and the response to treatments for sepsis? CONCLUSIONS: Knowledge advances in multiple clinical domains have been incorporated in progressive iterations of the Surviving Sepsis Campaign guidelines, allowing for evidence-based recommendations for short- and long-term management of sepsis. However, the strength of existing evidence is modest with significant knowledge gaps and mortality from sepsis remains high. The priorities identified represent a roadmap for research in sepsis and septic shock.

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Section: Resultsmentioning

confidence: 99%

Surviving Sepsis Campaign Research Priorities 2023

De Backer,

Deutschman,

Hellman

et al. 2024

Critical Care Medicine

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“…The long non-coding RNA cancer susceptibility candidate 2 (CASC2) is another lnRNA that has been demonstrated to regulate AQP1 expression in lung carcinoma epithelial cells and lung injury mouse models via the miR-144-3p/AQP1 axis [ 34 ]. In humans, CASC2 levels have been found to be decreased in septic patients compared to healthy individuals and could be utilized as a biomarker for disease severity and mortality [ 57 ].…”

Section: Aquaporin Long Non-coding Rnas and Micro Rnas In Clinical An...mentioning

confidence: 99%

Aquaporin Expression and Regulation in Clinical and Experimental Sepsis

Lotsios,

Keskinidou,

Dimopoulou

et al. 2023

IJMS

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Sepsis is an inflammatory disorder caused by the host’s dysfunctional response to infection. Septic patients present diverse clinical characteristics, and in the recent years, it has been the main cause of death in intensive care units (ICU). Aquaporins, membrane proteins with a role in water transportation, have been reported to participate in numerous biological processes. Their role in sepsis progression has been studied extensively. This review aims to examine recent literature on aquaporin expression and regulation in clinical sepsis, as well as established experimental models of sepsis. We will present how sepsis affects aquaporin expression at the molecular and protein level. Moreover, we will delve into the importance of aquaporin regulation at transcriptional, post-transcriptional, translational, and post-translational levels in sepsis by presenting data on aquaporin regulation by non-coding RNAs and selected chemical molecules. Finally, we will focus on the importance of aquaporin single-nucleotide polymorphisms in the setting of sepsis.

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“…LncRNA гена-кандидата 2 на восприимчивость к раку (cancer susceptibility candidate gene 2, CASC2) ингибирует воспаление и полиорганную дисфункцию. Экспрессия lncRNA CASC2 снижена у пациентов с сепсисом по сравнению с контрольной группой здоровых пациентов и у умерших от сепсиса по сравнению с выжившими [80].…”

Section: длинные некодирующие Rna (Lncrna)unclassified

Биологические Маркеры Сепсиса

Радыгина,

Мочалова

2023

Microbiology Independent Research Journal (MIR Journal)

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В настоящее время проблема ранней диагностики сепсиса, оценки эффективности проводимой терапии и прогноза течения заболевания крайне актуальна. При сепсисе своевременное оказание медицинской помощи осложнено нечеткостью симптомов и отсутствием специфического диагностического теста. В связи с этим во всем мире ведется поиск биологических маркеров сепсиса: диагностических, прогностических и терапевтических. В обзоре суммированы результаты исследований по диагностической ценности биологических маркеров сепсиса, их чувствительности, специфичности и прогностической ценности из научных публикаций, представленных в международных базах данных.

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Potential of circulating lncRNA CASC2 as a biomarker in reflecting the inflammatory cytokines, multi‐organ dysfunction, disease severity, and mortality in sepsis patients

Cited by 15 publications

References 21 publications

Surviving Sepsis Campaign Research Priorities 2023

Surviving Sepsis Campaign Research Priorities 2023

Aquaporin Expression and Regulation in Clinical and Experimental Sepsis

Биологические Маркеры Сепсиса

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