Potential of Chitosan and its derivatives for controlled drug release applications – A review

Safdar, Rizwan; Omar, Abdul Aziz; Appusamy, Arunagiri; Iyyaswami, Regupathi; Murugesan, Thanabalan

doi:10.1016/j.jddst.2018.10.020

Cited by 105 publications

(64 citation statements)

References 152 publications

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“…This means that the release rate of the Flourensia spp. extracts encapsulated in alginate is constant and independent of the concentration (Safdar et al, 2019). The results obtained agree with those reported by Li et al (2007a,b), who found that the release of garlic extracts, microencapsulated in ethyl cellulose/cellulose acetate phthalate, follows a zero-order kinetics between 60 and 120 min.…”

Section: Microencapsulated Extract Release In Simulated Gastrointestisupporting

confidence: 91%

“…On the other hand, to determine the reaction order of the release kinetics, the calculations of the release rate constants of the encapsulated extracts were performed (Table 3). This approach is important as it could predict the release behavior of an extract or active compound, and it helps to develop strategies to improve the release (Safdar et al, 2019). Except for F. microphylla fresh microcapsules (Fmf), all the encapsulated extracts were fitted with zero-order model (K o ), as a correlation adjustment greater than 0.9 was obtained.…”

Section: Microencapsulated Extract Release In Simulated Gastrointestimentioning

confidence: 99%

“…Another kinetic model reported to understand the active compounds release was proposed by Higuchi (1963), which describes an empirical process to drug release, and it is based-on Fick Law. Higuchi model (K H ) considers that the release of a drug depends on time, thus, it is possible that an active principle is released following a zero-order model at the beginning of the ingestion and later change to a different behavior (Safdar et al, 2019). Then, from Table 3 it can be seen that the microcapsules of the extracts of F. cernua and F. retinophylla (fresh and dried) followed a zero-order model, and that a Higuchi model is also adjusted.…”

Section: Microencapsulated Extract Release In Simulated Gastrointestimentioning

confidence: 99%

“…The study of the release of bioactive compounds from capsules in the gastrointestinal (GI) tract receives special interest, in such a way that it is possible to guarantee their integrity on their path to the release in a specific site and achieve the maximum effects (Jafari and McClements, 2017). In order to predict the release mechanisms of the bioactive compounds from microcapsules are used kinetic models of zero-order (K o ), first-order (K 1 ), and Higuchi (K H ) (Safdar et al, 2019). These models may optimize the extract release during the passage in the GI tract.…”

Section: Introductionmentioning

confidence: 99%

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In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla

Rodríguez

Puente-Romero

Jiménez

et al. 2019

Industrial Crops and Products

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A B S T R A C TRecently, some species of the genus Flourensia have been identified by their potential health effects (e.g. antiinflammatory and apoptotic). Encapsulation of plant extracts is a process that can allow an adequate dosage administration, as well as to protect bioactive compounds and improve their controlled release in the gastrointestinal (GI) system. Therefore, the aims of this work were: to microencapsulate the ethanol extracts of F. cernua, F. microphylla, and F. retinophylla; and to evaluate the controlled release of the microencapsuled extracts in an in vitro GI system. Leaves of Flourensia spp. were collected in wild sites of Coahuila State, and the ethanol extracts were obtained by the Soxhlet method. The encapsulation was performed by the gelation technique, using alginate. The microcapsules formed were characterized in terms of total phenol content (Folin-Ciocalteu method), antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulphonic) diammonium acid (ABTS), and the ferric reducing antioxidant power (FRAP) assays, scanning electron microscopy (SEM), and thermal analysis, and in vitro GI digestion. The microcapsules were found to have spherical-shape and a micro-scale dimension in the range of 2.1-68.8 μm. Also, the built of microcapsules was confirmed by the appearance of an exothermic peak centered at˜600°C in the DSC analysis. F. microphylla noted for its strong antioxidant activity, even in its encapsulated form. In the gastric system the extracts of fresh microcapsules were released from 7.7% to 14.5%, while values of 26.5% to 53.3% were observed for those dried. For the intestinal system, the higher release was observed for dried microcapsules (59.9% to 78.4%) than for those fresh (26.3% to 30.2%). Thus, it was demonstrated that the alginate microcapsule protected the extracts until they were delivered to the target site in the GI model, and this effect was better with the dried microcapsules of Flourensia spp. This study would set the guide for the application of Flourensia spp. extracts in order to take advantage of their benefits to human health.

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Section: Microencapsulated Extract Release In Simulated Gastrointestisupporting

confidence: 91%

Section: Microencapsulated Extract Release In Simulated Gastrointestimentioning

confidence: 99%

Section: Microencapsulated Extract Release In Simulated Gastrointestimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla

Rodríguez

Puente-Romero

Jiménez

et al. 2019

Industrial Crops and Products

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“…The ideal drug release is rapid, at a constant rate, and sustained so that the drug be immediately effective while achieving a long effect [164]. Chitosan derivative nanoparticles can easily achieve a sustained slow release, increasing bioavailability and therapeutic efficacy while reducing side effects [165].…”

Section: Controlled Drug Deliverymentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

514

260

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Polymer Coatings for Food Applications

Mostafavi¹,

Zaeim²

2020

Polymer Coatings

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Potential of Chitosan and its derivatives for controlled drug release applications – A review

Cited by 105 publications

References 152 publications

In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla

In vitro gastrointestinal digestion of microencapsulated extracts of Flourensia cernua, F. microphylla, and F. retinophylla

Chitosan Derivatives and Their Application in Biomedicine

Polymer Coatings for Food Applications

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